Antimicrobial Activity of Brown Alga Eisenia bicyclis against Methicillin-resistant Staphylococcus aureus

Eom, Sung‐Hwan; Park, Jaehong; Yu, Daeung; Choi, Ji-Il; Choi, Jong-Duck; Lee, Myung-Suk; Kim, Young‐Mog

doi:10.5657/fas.2011.0251

Cited by 23 publications

(34 citation statements)

References 24 publications

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“…In order to identify an anti-acne substance from the EtOAc-soluble fractions of E. bicyclis, we screened the antibacterial activity of previously isolated phlorotannins against acne-related bacteria. It is reported that marine-derived polyphenols (phlorotannins) are believed as the active components of E. bicyclis (Eom et al 2013). Recently, we have reported that successive column chromatographic purification of the EtOAc-soluble extract led to the isolation and characterization of six phloroglucinol derivatives: eckol (1), FF (2), 7-phloroeckol (3), dioxinodehydroeckol (4), phlorofucofuroeckol-A (PFF) (5), and dieckol (6) (Eom et al 2013).…”

Section: Mic Value Of Isolated Phlorotannins From Eisenia Bicyclismentioning

confidence: 99%

“…It is reported that marine-derived polyphenols (phlorotannins) are believed as the active components of E. bicyclis (Eom et al 2013). Recently, we have reported that successive column chromatographic purification of the EtOAc-soluble extract led to the isolation and characterization of six phloroglucinol derivatives: eckol (1), FF (2), 7-phloroeckol (3), dioxinodehydroeckol (4), phlorofucofuroeckol-A (PFF) (5), and dieckol (6) (Eom et al 2013). In this report, we demonstrate the antimicrobial activities of these compounds against acne-related bacteria.…”

Section: Mic Value Of Isolated Phlorotannins From Eisenia Bicyclismentioning

confidence: 99%

“…The antibacterial activity of the EtOAc-soluble extract against acne-related bacteria was higher than those of other-soluble fractions. Eom et al (2011) reported that the EtOAc-soluble extract of E. bicyclis exhibited the highest antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and …”

Section: Measurement Of Mic and Mbc Values Of Eisenia Bicyclis Extractmentioning

confidence: 99%

“…This brown alga has also been reported to exhibit several medicinal functions, such as anti-tumor (Ermakova et al 2013), anti-Alzheimer's disease (Ahn et al 2012), anti-atherosclerosis (Kang et al 2006), antiinflammatory (Jung et al 2013), anti-coagulant activities (Jeong et al 2009), anti-allergic disease and anti-cancer activities (Shibata et al 2003). In addition, phlorotannins have been known to show potent antimicrobial activity against several microorganisms (Eom et al 2013).…”

Section: Microorganism and Culturementioning

confidence: 99%

“…As an alternative way, natural materials such as plantderived or marine-derived compounds in combination with traditional medicines against drug-resistant bacteria may be used as an effective approach for restoration of antibiotic activity (Eom et al 2013). Taylor et al (2005) reported that green tea components may display synergy with conventional antibiotics against gram-negative bacteria.…”

Section: Synergic Effects Between Ff and Antibiotics Against Propionimentioning

confidence: 99%

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In vitro antibacterial and synergistic effect of phlorotannins isolated from edible brown seaweed Eisenia bicyclis against acne-related bacteria

Lee¹,

Eom²,

Lee³

et al. 2014

ALGAE

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To develop effective and safe acne vulgaris therapies with a continuing demand for new solutions, we investigated unique efficacy of an antibacterial agent from marine brown alga Eisenia bicyclis in treating acne vulgaris. The methanolic extract of E. bicyclis exhibited potential antibacterial activity against acne-related bacteria. The ethyl acetate fraction showed the strongest antibacterial activity against the bacteria among solvent fractions. Six compounds (1-6), previously isolated from the ethyl acetate fraction of E. bicyclis, were evaluated for antibacterial activity against acne-related bacteria. Among them, compound 2 (fucofuroeckol-A [FF]) exhibited the highest antibacterial activity against acne-related bacteria with a minimum inhibitory concentration (MIC) ranging from 32 to 128 μg mL -1 . Furthermore, FF clearly reversed the high-level erythromycin and lincomycin resistance of Propionibacterium acnes. The MIC values of erythromycin against P. acnes were dramatically reduced from 2,048 to 1.0 μg mL -1 in combination with MIC of FF (64 μg mL -1). The fractional inhibitory concentration indices of erythromycin and lincomycin were measured from 0.500 to 0.751 in combination with 32 or 64 μg mL -1 of FF against all tested P. acnes strains, suggesting that FF-erythromycin and FF-lincomycin combinations exert a weak synergistic effect against P. acnes. The results of this study suggest that the compounds derived from E. bicyclis can be a potential source of natural antibacterial agents and a pharmaceutical component against acnerelated bacteria.Key Words: acne-related bacteria; antimicrobial activity; Eisenia bicyclis; phlorotannins; synergistic effect INTRODUCTIONAcne vulgaris is a common skin disease affecting children and adolescents. The pathogenesis of acne is multifactorial and complex. There are four important factors that cause acne in humans, such as an increase in sebum secretion, keratinization of the follicle, bacteria, and inflammation (Farrar and Ingham 2004). Pro pionibacterium acnes, Staphylococcus epidermidis, S. aureus, and Pseudomonas aeruginosa are often involved in the development of abnormal follicular keratinization and inflammation (Yamaguchi et al. 2009 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 48 MATERIALS AND METHODS Raw materials and extractionIn late September 2010, E. bicyclis was purchased from Ulleung Trading Co. (Ulleung-gun, Korea). A voucher specimen has been deposited in the author's laboratory. Dried E. bicyclis was finely ground and powdered with a food mixer (HMF-1000A; Hanil Electronics, Seoul, Korea). The dried powder was vacuum-packed and kept at -20°C until use. The dried E. bicyclis powder (1.0 kg) was extracted with methanol (MeOH; 10 L × 3) at 70°C for 3 h (3 times) and the solvent was evaporated ...

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Section: Mic Value Of Isolated Phlorotannins From Eisenia Bicyclismentioning

confidence: 99%

Section: Mic Value Of Isolated Phlorotannins From Eisenia Bicyclismentioning

confidence: 99%

Section: Measurement Of Mic and Mbc Values Of Eisenia Bicyclis Extractmentioning

confidence: 99%

Section: Microorganism and Culturementioning

confidence: 99%

Section: Synergic Effects Between Ff and Antibiotics Against Propionimentioning

confidence: 99%

See 3 more Smart Citations

In vitro antibacterial and synergistic effect of phlorotannins isolated from edible brown seaweed Eisenia bicyclis against acne-related bacteria

Lee¹,

Eom²,

Lee³

et al. 2014

ALGAE

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Biological Phlorotannins of Eisenia bicyclis

Lee

Kim²

2015

Marine Algae Extracts

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In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin‐Resistant Staphylococcus aureus

Eom

Kim

Lee

et al. 2012

Phytotherapy Research

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Six phlorotannins, isolated from Eisenia bicyclis, were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) of the compounds were in the range 32 to 64 µg/mL. Phlorofucofuroeckol-A (PFF) exhibited the highest anti-MRSA activity, with an MIC of 32 µg/mL. An investigation of the interaction between these compounds and the β-lactam antibiotics ampicillin, penicillin, and oxacillin revealed synergistic action against MRSA in combination with compound PFF. To our knowledge, this is the first report on the anti-MRSA activity of phlorotannins from E. bicyclis. The results obtained in this study suggest that the compounds derived from E. bicyclis can be a good source of natural antibacterial agents against MRSA.

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Antimicrobial Activity of Brown Alga Eisenia bicyclis against Methicillin-resistant Staphylococcus aureus

Cited by 23 publications

References 24 publications

In vitro antibacterial and synergistic effect of phlorotannins isolated from edible brown seaweed Eisenia bicyclis against acne-related bacteria

In vitro antibacterial and synergistic effect of phlorotannins isolated from edible brown seaweed Eisenia bicyclis against acne-related bacteria

Biological Phlorotannins of Eisenia bicyclis

In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin‐Resistant Staphylococcus aureus

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