Antimicrobial activity of commercial organic honeys against clinical isolates of human pathogenic bacteria

Obey, Jackie K.; Ngeiywa, Moses; Lehesvaara, Marjatta; Kauhanen, Jussi; Wright, Atte von; Tikkanen-Kaukanen, Carina

doi:10.1007/s13165-022-00389-z

Cited by 4 publications

(6 citation statements)

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“…This is because multi-drug resistant (MDR) bacteria carries the highest rate of morbidity, serious complications, and mortality since affective drugs are not available or very limited [ 1 ]. AMR has been on the rise worldwide for the past several years, including the last-resort drugs that are regularly prescribed [ 2 ]. Globally, the number of deaths associated with AMR is more than 700,000 annually, which is expected to reach 10 million by 2050, unless targeted actions are taken before then [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

The Antimicrobial Effects of Saudi Sumra Honey against Drug Resistant Pathogens: Phytochemical Analysis, Antibiofilm, Anti-Quorum Sensing, and Antioxidant Activities

et al. 2022

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Honey exhibited potential antimicrobial activity against multidrug resistant (MDR) bacteria that continues to be a serious health problem. We reported the in-vitro activity of Saudi Sumra honey against clinical pathogenic bacteria and fungi, antibiofilm, anti-quorum-sensing (QS) and antioxidant activities in relation to its phytochemical composition assessed by gas chromatography-mass spectrometry (GC-MS). Broth dilution method and scavenging activities against 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and β-carotene bleaching assays were performed. The GC-MS analysis of Sumra honey showed that 2,4-dihydroxy-2,5-dimethyl-3(2H)-furan-3-one 1-methylcyclopropanemethanol were the major identified phytoconstituents. Sumra honey showed a minimum inhibitory concentration (MIC) to clinical isolates of Staphylococcus aureus including methicillin-resistant Staphylococcus aureus (MRSA) at 300 mg/mL, Pseudomonas aeruginosa (250 mg/mL), Escherichia coli (350 mg/mL) and Acinetobacter baumannii (250 mg/mL); clinical fungal isolates—Candida auris (600 mg/mL) and Cryptococcus neoformans (>1000 mg/mL); wild type fungal isolates—Candida krusei (>1000 mg/mL) and Candida albicans (700 mg/mL). In addition, Sumra honey demonstrated promising inhibition targeting biofilm formation by 59% for Bacillus subtilis, 48% for S. aureus, 38% for E. coli, and 33.63% for P. aeruginosa. The violacein production in Chromobacterium violaceum was reduced to 68%, whereas pyocyanin production in P. aeruginosa was reduced to 54.86% at ½ MIC. Furthermore, Sumra honey exhibited strong antioxidant activities (DPPH − IC50 = 7.7 mg/mL; ABTS − IC50 = 5.4 mg/mL; β-carotene − IC50 = >20 mg/mL). Overall, obtained data highlighted the promising potential therapeutic use of Sumra honey treating infections caused by MDR bacteria and fungi. Moreover, Sumra honey can be a good candidate as an inhibitor agent for bacterial cellular communication in strains of P. aeruginosa and C. violaceum.

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Section: Introductionmentioning

confidence: 99%

The Antimicrobial Effects of Saudi Sumra Honey against Drug Resistant Pathogens: Phytochemical Analysis, Antibiofilm, Anti-Quorum Sensing, and Antioxidant Activities

et al. 2022

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“…Honey's color can change depending on a number of factors, including the type of flowers from which it was made, the minerals it contains, how it was stored and processed, the weather conditions during the nectar flow, and the temperature at which it ripened in the hive, the ratio of fructose to glucose and the nitrogen content. Honey produced from the nectars of oak, pine, manuka and chestnut trees are termed dark-colored honey and are also the most frequently utilized for medicinal food purposes [4].…”

Section: Colormentioning

confidence: 99%

“…Current science has validated the special nutritional and therapeutic advantages of this sweet and viscous material [3] as it possesses therapeutic potential both for systemic and topical applications. Some honey varieties that show noteworthy levels of antioxidants and antimicrobial activity are known as medicinal or apitherapeutic honey [4]. Vitamins and polyphenols contained in honey are accountable for its apitherapeutic properties.…”

Section: Introductionmentioning

confidence: 99%

“…Vitamins and polyphenols contained in honey are accountable for its apitherapeutic properties. Pine, oak, chestnut and Manuka honey in addition to been dark-colored are also the most frequently utilized natural agents for medicinal food purposes [4]. Furthermore, Honey has an amazing capacity to destroy germs.…”

Section: Introductionmentioning

confidence: 99%

“…It is produced when bees feed on the nectar of R. ponticum and R. luteum (Rhododendron flowers) and causes poisoning upon consumption. Nonetheless, mad honey is still been produced traditionally and sold to serve for an alternative medicine against various health aliments, like high blood glucose, pain and also to act as a sexual stimulant [4]. Topically, honey has been shown to be effective in the treatment of numerous skin issues, such as burns, wounds, ulcers, bedsores, acne, and burns [6].…”

Section: Introductionmentioning

confidence: 99%

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Natural Honey (Raw Honey): Insights on Quality, Composition, Economic and Health Effects: A Comprehensive Review

Edo,

Onoharigho,

Akpoghelie

et al. 2023

Food Science and Engineering

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Natural honey is one of the most significant foods produced and consumed globally, it has pleasing sensory characteristics such a light colour, as well as a recognizable flavor and aroma. In addition, natural honey has been associated with potential biological properties since it contains organic acids, sugars, minerals, enzymes, phenolic, volatile compounds, methylglyoxal, amino acids, and vitamins. All of these features make this viscous substance extremely desirable by consumers for health and wellness purposes and likewise by manufacturing industries for production purposes thus increasing its market value. Since honey plays a vital role in balancing human nutrition being a better alternative to sugar, and further serves as a natural raw material in most industrial products the world over, its socio-economic importance to human development and industrial output cannot be overemphasized. The income generating and job creating capacity of the honey industry has been beneficial both to corporate organizations and various governments of the world. It is therefore the aim of this study to provide information on the quality, composition, health effects and economics of this high value viscous liquid.

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Physicochemical, Antimicrobial Properties and Mineral Content of Several Commercially Available Honey Samples

Yaman,

Nicolescu,

Tepe

et al. 2024

Applied Sciences

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Ensuring food safety and protecting consumers are major aspects for commercialized products. Honey, the most prominent in the class of bee products, requires special regulations due to its origin as a natural product. Mislabeling, imitation, and adulteration represent a source of risks for human health. Specific determinations and analyses are essential for controlling the sector and preventing unfair competition. To compare and establish the correct labeling of several different honeys, melissopalynological, physicochemical, mineral content, and microbiological analyses were carried out on 18 samples commercially available in different countries, namely Türkiye, Romania, Bulgaria, and Northern Cyprus. The honey labels were in accordance with the determined pollen content. The physiochemical parameters showed high variability: 4.07–5.25 (pH), 79.95–83.45 (°Brix), 0.262–1.452 µS/cm (electrical conductivity), and 14.6–18.4% (moisture). The samples were quantitatively high in K, P, Na, and Ca, with the highest cumulative mineral content being found for honeys containing Fagaceae pollen. Additionally, the antimicrobial potential of the various honey samples was evaluated against selected bacteria, employing the disk diffusion and serial dilution methods. Results revealed that the honey samples exhibited increased antibacterial activity against Gram-negative bacteria, with notable activity against S. typhimurium, and moderate activity against Gram-positive S. aureus.

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Antimicrobial activity of commercial organic honeys against clinical isolates of human pathogenic bacteria

Cited by 4 publications

References 61 publications

The Antimicrobial Effects of Saudi Sumra Honey against Drug Resistant Pathogens: Phytochemical Analysis, Antibiofilm, Anti-Quorum Sensing, and Antioxidant Activities

The Antimicrobial Effects of Saudi Sumra Honey against Drug Resistant Pathogens: Phytochemical Analysis, Antibiofilm, Anti-Quorum Sensing, and Antioxidant Activities

Natural Honey (Raw Honey): Insights on Quality, Composition, Economic and Health Effects: A Comprehensive Review

Physicochemical, Antimicrobial Properties and Mineral Content of Several Commercially Available Honey Samples

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