Antimicrobial activity of copper and copper(<scp>i</scp>) oxide thin films deposited via aerosol-assisted CVD

Hassan, Iman A.; Parkin, Ivan P.; Nair, Sean P.; Carmalt, Claire J.

doi:10.1039/c4tb00196f

Cited by 76 publications

(51 citation statements)

References 36 publications

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“…Some of these antimicrobial systems demonstrate poor antimicrobial efficacy compared with the CVZnO silicone reported here . However, other systems exhibited comparable, or enhanced antimicrobial activity . The use of thin‐film antimicrobial coatings, or copper surfaces however, presents a substantial financial burden to healthcare institutions.…”

Section: Resultsmentioning

confidence: 82%

“…One strategy to minimize the spread of infection is the use of antimicrobial surfaces . Many such materials have been prepared for both hard and soft surfaces, for example, the use of microbiocide releasing surfaces, silver‐ion technology, copper surfaces, or surfaces covalently attached to peptides . One slightly different approach involves the photosensitization of bacteria.…”

Section: Introductionmentioning

confidence: 99%

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Dual‐Mechanism Antimicrobial Polymer–ZnO Nanoparticle and Crystal Violet‐Encapsulated Silicone

Noimark

Weiner

Noor

et al. 2015

Adv Funct Materials

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101

120

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The prevalence of healthcare-associated infection caused by multidrugresistant bacteria is of critical concern worldwide. It is reported on the development of a bactericidal surface prepared by use of a simple, upscalable, two-step dipping strategy to incorporate crystal violet and di(octyl)-phosphinic-acid-capped zinc oxide nanoparticles into medical grade silicone, as a strategy to reduce the risk of infection. The material is characterized by UV-vis absorbance spectroscopy, X-ray photoelectron spectroscopy (XPS), inductively coupled plasma-optical emission spectroscopy (ICP-OES) and transmission electron microscopy (TEM) and confi rmed the incorporation of the ZnO nanoparticles in the polymer. The novel system proves to be a highly versatile bactericidal material when tested against both Staphylococcus aureus and Escherichia coli , key causative micro-organisms for hospitalacquired infection (HAI). Potent antimicrobial activity is noted under dark conditions, with a signifi cant enhancement exhibits when the surfaces are illuminated with a standard hospital light source. This polymer has the potential to decrease the risk of HAI, by killing bacteria in contact with the surface.

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Section: Resultsmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Dual‐Mechanism Antimicrobial Polymer–ZnO Nanoparticle and Crystal Violet‐Encapsulated Silicone

Noimark

Weiner

Noor

et al. 2015

Adv Funct Materials

Self Cite

101

120

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“…compared to micro-particles. [8][9][10] By gel spinning fibrous structures of CuFe 2 O 4 could be prepared and subsequently loaded with Agnanoparticles to obtain high antibacterial magnetic fibres. 6 Formation of TiO 2 as surface layer and incorporation of copper as antimicrobial agent has been proposed to introduce antimicrobial surface properties on Ti-implants.…”

Section: Introductionmentioning

confidence: 99%

Copper(i)oxide microparticles – synthesis and antimicrobial finishing of textiles

et al. 2015

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Copper containing particles are of high interest to provide antibacterial activity to textiles for medical products, hygiene application or where odor formation as result of bacterial activity has to be controlled. Cu(I)oxide microparticles with a rather uniform diameter between 1.5 and 2 µ m can be prepared by controlled reduction of alkaline Cu(II)-tartaric acid complexes. Such particles can be bound to textile surfaces by means of a pigment binder system used in pigment dyeing. By a simple pad-dry process textile fabrics with a Cu-content of 250 -270 mg Cu / kg fabric could be prepared. The samples (fabrics) exhibited a reduction in viability of 100 % for Staphylococcus aureus and 84 % for Klebsiella pneumonia as estimated by the ASTM E2149 antimicrobial test. Simulated wash procedures led to a reduction in Cu-content to 60 -50 % of the initial value. Reduction in viability remained at 99 % for Staphylococcus aureus and 78 % for Klebsiella pneumoniae. The new process is of high value to impart antimicrobial properties to textile products because an antimicrobial product with good wash permanence can be delivered using rather simple processing and ordinary chemicals. Experimental Material and ChemicalsCopper(I)oxide microparticles were be bound to textile surfaces by means of a pigment binder system to provide antibacterial activity with good wash permanence, using rather simple processing and ordinary chemicals.

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“…Many techniques have been suggested for application to soft and hard surfaces, including silver or copper coated surfaces [20][21][22] , self-cleaning surfaces 23,24 and enzyme or bacteriophage immobilized surfaces 25,26 . In addition, the incorporation of light-activated antimicrobial agents (LAAAs) into surfaces is considered a promising technique [27][28][29] .…”

Section: Introductionmentioning

confidence: 99%

White Light-Activated Antimicrobial Paint using Crystal Violet

Hwang

Allan

Parkin

2015

ACS Appl. Mater. Interfaces

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Crystal violet (CV) was incorporated into acrylic latex to produce white light activated antimicrobial paint (WLAAP). Measurement of the water contact angle of the WLAAP showed that the water contact angle increased with increasing CV concentration. In a leaching test over 120 h, the amount of CV which leached from the WLAAPs was close to the detection limit (<0.03 %). The WLAAPs were used to coat samples of polyurethane and these showed bactericidal activity against E. coli which is a key causative agent of healthcare-associated infections (HAIs). A reduction in the numbers of viable bacteria was observed on the painted coated polyurethane after 6 h in the dark and the bactericidal activity increased with increasing CV concentration (P <0.1). After 6 h of white light exposure, all of coated polyurethanes demonstrated a potent photobactericidal activity and it was statistically confirmed that the WLAAP showed better activity in white light than in the dark (P <0.05). At the highest CV concentration, the numbers of viable bacteria fell below the detection limit (<10 3 CFU/mL) after 6h of white light exposure. The difference in antimicrobial activity between the materials in the light and dark was 0.48 log at CV 250 ppm and it increased by 0.43 log at each increment of CV 250 ppm. The difference was the highest (>1.8 log) at the highest CV concentration (1000 ppm).These WLAAPs are promising candidates for use in healthcare facilities to reduceHAIs.

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Antimicrobial activity of copper and copper(i) oxide thin films deposited via aerosol-assisted CVD

Abstract: High antimicrobial efficacy of Cu and Cu2O films, deposited via aerosol-assisted chemical vapour deposition, was observed against E. coli and S. aureus.

Cited by 76 publications

References 36 publications

Dual‐Mechanism Antimicrobial Polymer–ZnO Nanoparticle and Crystal Violet‐Encapsulated Silicone

Dual‐Mechanism Antimicrobial Polymer–ZnO Nanoparticle and Crystal Violet‐Encapsulated Silicone

Copper(i)oxide microparticles – synthesis and antimicrobial finishing of textiles

White Light-Activated Antimicrobial Paint using Crystal Violet

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