Antimicrobial Activity of Ethylenediaminedisuccinate Metal Complexes. Short Communication

Costa, Natália J. S.; Bombardieri, Cíntia R.; Kuribayashi, Juliana Sayuri; Camargo, Maristela Martins de; Andrade, Leandro H.; Kagohara, Edna; Espósito, Breno Pannia

doi:10.1002/cbdv.200890196

Cited by 9 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, for the three cadmium complexes the toxicity on MRC5 was negative at 1 lg/mL and largely diminished (30% or 100% less active) at 10 lg/mL in comparison to the values obtained for the salts. This have been already observed, that free ions are more toxic than their complexes, probably due to the decreased bioavaibility of the metal ion [24]. So, it could be thought that [CdBr 2 (3TTSCH) 2 ], [CdBr 2 (3TTSCH)] and [CdCl 2 (3TTSCH)] could be interesting as antifungal therapeutic especially on A. fumigatus with high values between 50 and 55 mm.…”

Section: Biological Activitiesmentioning

confidence: 92%

“…cystic fibrosis, HIV) and usually responsible of many kind of resistance. This activity could be explain because that highly lethal fungi employ chelator biosynthesis in order to acquire iron from the host [24].…”

Section: Biological Activitiesmentioning

confidence: 99%

“…Conversely to the antifungal results, no antibacterial activity was observed for the ligand 3TTSCH against all bacterial strains tested. Among the complexes tested, cadmium(II) com- [24][25][26].…”

Section: Biological Activitiesmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes

Alomar

Landreau

Kempf

et al. 2010

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

The reaction of zinc(II) chloride, cadmium(II) chloride and bromide with 3-thiophene aldehyde thiosemicarbazone leads to the formation of a series of new complexes. They have been characterized by spectroscopic studies: infrared, (1)H NMR, and electronic spectra. The crystal structures of the compound [ZnCl(2)(3TTSCH)(2)] and [CdBr(2)(3TTSCH)(2)] have been determined by X-ray diffraction methods. For the complexes [ZnCl(2)(3TTSCH)(2)] and [CdBr(2)(3TTSCH)(2)], the central ion is coordinated through the sulfur, and for the complexes [CdCl(2)(3TTSCH)], [CdBr(2)(3TTSCH)] the ion is coordinated through the sulfur as well as azomethine nitrogen atom of the thiosemicarbazone. In addition, fungistatic and bacteriostatic activities of both ligand and complexes have been evaluated. Cadmium(II) complexes have shown the most significant activities.

show abstract

Section: Biological Activitiesmentioning

confidence: 92%

Section: Biological Activitiesmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes

Alomar

Landreau

Kempf

et al. 2010

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

show abstract

“…It is well‐known that microorganisms secrete chelators in their environment to capture free iron essential for their growth. It may be interesting to test the capacity of our complexes to chelate this metal in perspective of interfering in the development processes of such pathogenic microorganisms [45] . Due to the efficiency of our compounds against human pathogens, they may be used as potential antiseptic agents.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, Antibacterial and Antifungal Activities Evaluation of Metal Complexes With Benzaldehyde‐4‐methylthiosemicarbazone Derivatives

et al. 2022

View full text Add to dashboard Cite

Herein, to develop the comprehension of the microbiological activity of metal complexes based on benzaldehyde‐N4‐thiosemicarbazone derivatives, we described the synthesis, characterization of copper(II), zinc(II) and cadmium(II) complexes with vanillin‐4‐methylthiosemicarbazone (MTSVN) and 3,4‐dihydroxybenzaldehyde‐4‐methylthiosemicarbazone (MTSDHB). The crystal structures of the [ZnCl2(MTSVN)2] (L1 C1) and [CdBr2(MTSDHB)2.H2O]2 (L2C5) complexes were determined by the single X‐Ray diffraction method, the central ion is coordinated through the sulphur. For the other complexes, the ion is coordinated through the sulfur as well as azomethine nitrogen atom of the thiosemicarbazone. All these compounds, the two ligands and the new nine complexes were screened in vitro for their antifungal activity against human pathogenic fungi: Candida albicans and Aspergillus fumigatus, and for their antibacterial activity against Gram (+) bacteria such as Bacillus subtilis and Enterococcus faecalis as well as against Gram (−) bacteria such as Paracoccus yeei and Acinetobacter baumanii. By investigating the structure‐activity relationships, we found that the two ligands MTSVN (L1) exhibited significant effect against E. faecalis and A. baumanii and the MTSDHB (L2) acted only against E. faecalis. Furthermore, all the complexes (L1C1–L1C4 and L2C1–L2C5) showed significant antifungal and antibacterial activities against gram‐positive, gram‐negative bacteria, and two fungal human pathogens.

show abstract

“…This activity could be explained by the fact that the lethal fungi employ chelator biosynthesis to acquire iron from the host. [ 40 ]…”

Section: Resultsmentioning

confidence: 99%

Synthesis, characterization, antifungal and antibacterial activities evaluation of copper (II), zinc (II) and cadmium (II) chloride and bromide complexes with new (E)‐1‐(3,4‐dimethoxybenzylidene)‐4‐methylthiosemicarbazone ligand

Jaafar

Fix‐Tailler

Mansour

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

The reactions of Cu (II), Zn (II) and Cd (II) chloride or bromide with (E)‐1‐(3,4‐dimethoxybenzylidene)‐4‐methylthiosemicarbazone (MTSVT) lead to the formation of new complexes. They were characterized by spectroscopic studies: IR, 1H and 13C NMR. The crystal structures of the compounds [MTSVT] (L), [ZnBr2(MTSVT)2] (2), [CdCl2(MTSVT)2] (3) and [CdBr2(MTSVT)2.H2O] (4) were determined by X‐ray diffraction. For complexes 2–4, the ion is coordinated through the sulfur atom. All compounds were tested for their antifungal activity against human pathogenic fungi Candida albicans and Aspergillus fumigatus, and for their antibacterial activity against Gram (+) Bacillus subtilis and Enterococcus faecalis as well as against Gram (−) bacteria such as Paracoccus yeei and Acinetobacter baumanii. The results indicated that the metal complexes exhibited a marked enhancement in antibacterial activity compared with the parent Schiff base.

show abstract

Antimicrobial Activity of Ethylenediaminedisuccinate Metal Complexes. Short Communication

Cited by 9 publications

References 8 publications

Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes

Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes

Synthesis, Characterization, Antibacterial and Antifungal Activities Evaluation of Metal Complexes With Benzaldehyde‐4‐methylthiosemicarbazone Derivatives

Synthesis, characterization, antifungal and antibacterial activities evaluation of copper (II), zinc (II) and cadmium (II) chloride and bromide complexes with new (E)‐1‐(3,4‐dimethoxybenzylidene)‐4‐methylthiosemicarbazone ligand

Contact Info

Product

Resources

About