Antimicrobial activity of extracts of herbal plants used in the traditional medicine of Jordan

Mahasneh, Adel M.; El-Oqlah, Ahmad

doi:10.1016/s0378-8741(98)00132-9

Cited by 96 publications

(59 citation statements)

References 9 publications

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“…Cyclamen tubers have been used in the folk medicine for their sedative, purgative, antihelmintic, laxative, and abortive properties (Speroni et al, 2007). Different extracts of Cyclamen tubers were shown to possess cytotoxic, antimicrobial, spermicidal, analgesic, and anti-inflammatory activities (Ç aliş et al, 1997;Dall'Acqua et al, 2010;Kupchan et al, 1967;Mahasneh & El-Oqlah, 1999;Primorac et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

In vitrocytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated fromCyclamen persicumandCyclamen libanoticum

Hosry

Giorgio

Birer

et al. 2014

Pharmaceutical Biology

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Context: The genus Cyclamen L. (Primulaceae) is rich in saponins known to have interesting biological activities. Objective: To isolate saxifragifolin B and cyclamin, two triterpene saponins, from Cyclamen libanoticum Hildebr and Cyclamen persicum Mill, and to assess their cytotoxic, clastogenic/ aneugenic, and anticlastogenic effects, as well as antioxidant potential. Materials and methods: Saxifragifolin B and cyclamin were tested for their cytotoxicity against SK-BR-3, HT-29, HepG2/3A, NCI-H1299, BXPC-3, 22RV1, and normal DMEM cell lines using WST-1 assay. Their clastogenic/aneugenic activities and anticlastogenic effects against the anticancer drug mitomycin C were assessed by the in vitro micronucleus assay in CHO cells. Their antioxidant capacities were determined using Fe 2+ -chelating and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assays. Results: Both saponins were described for the first time in Cyclamen libanoticum. They showed strong cytotoxic activities against the tested cancer cell lines. Saxifragifolin B was found to be 56-and 37-times more active than mitomycin C against breast adenocarcinoma (SK-BR-3) and lung carcinoma (NCI-H1299), respectively. Also, saxifragifolin B did not induce micronuclei formation and prevented cells from mitomycin C clastogenic effect. Cyclamin induced a significant increase of micronucleated cells after metabolic activation with S9 mix, and did not possess any anticlastogenic activity. Both molecules exhibited low antioxidant activities as compared to reference compounds. Discussion and conclusions: This study showed the remarkable cytotoxic activity of saxifragifolin B, especially against breast adenocarcinoma and lung carcinoma and its chemoprotective activity against mitomycin C. Thus, saxifragifolin B could be suggested as a potential cytotoxic drug with a preventive effect against possible exposures to genotoxic agents.

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Section: Introductionmentioning

confidence: 99%

In vitrocytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated fromCyclamen persicumandCyclamen libanoticum

Hosry

Giorgio

Birer

et al. 2014

Pharmaceutical Biology

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“…The culture medium was poured into 120 mm sterile Petri dish to give a mean depth of 4.0 mm ± 0.5 mm (Altuner and Çetin, 2009;Altuner and Akata, 2010). 60, 100 and 150 µL aliquots of each extract was applied on sterile paper disks of 6 mm diameter end up with 440, 917 and 1375 µg/µL sample on each disk (Mahasneh and El-Oqlah, 1999;Silici and Koc, 2006). To get rid of any residual solvent which might interfere with the results, disks were left to dry overnight at 30°C in sterile conditions (Silici and Koc, 2006;Altuner et al, 2012aAltuner et al, , 2012b.…”

Section: Disk Diffusion Methodsmentioning

confidence: 99%

Antimicrobial screening of <i>Mnium stellare</i>

Canlı

Altuner

Akata

2015

Bangladesh J Pharmacol

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Many plants contain active substances that are known to be effective in both enhancing the wound healing process and lowering the incidence of wound infections. Previous studies have shown that bryophytes produce a variety of secondary metabolites that present pharmaceutical activities including antimicrobial activity against various pathogenic bacteria and fungi. The aim of this study was to investigate the antimicrobial activity of Mnium stellare against 17 bacterial and 1 fungal strains. Our present study has shown that the ethanol extract of M. stellare has antimicrobial activity against several Gram positive and negative microorganism tested, but its antimicrobial activity is notable especially against B. subtilis, S. typhimirium, S. aureus, S. carnosus, and S. epidermidis. These results are the very first report of the antimicrobial activity of M. stellare.

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“…Butanol, ethanol, petroleum ether, and aqueous extracts were prepared from nine Jordanian plants. Butanol extract showed superior antimicrobial activity compared with other extracts (Mahasneh & El-Oqlah, 1999 …”

Section: Plants As a Source Of Antimicrobial Agentsmentioning

confidence: 99%

Anticancer and Antimicrobial Potential of Plant-Derived Natural Products

Talib¹

2011

Phytochemicals - Bioactivities and Impact on Health

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Antimicrobial activity of extracts of herbal plants used in the traditional medicine of Jordan

Cited by 96 publications

References 9 publications

In vitrocytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated fromCyclamen persicumandCyclamen libanoticum

In vitrocytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated fromCyclamen persicumandCyclamen libanoticum

Antimicrobial screening of <i>Mnium stellare</i>

Anticancer and Antimicrobial Potential of Plant-Derived Natural Products

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