Antimicrobial Activity of Gallotannins Isolated from Mango (Mangifera indica L.) Kernels

Engels, Christina; Knödler, Matthias; Zhao, Yuanyuan; Carle, Reinhold; Gänzle, Michael G.; Schieber, Andreas

doi:10.1021/jf901621m

Cited by 138 publications

(121 citation statements)

References 34 publications

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“…Although some gallotannins have displayed some in vitro antitumor and antiproliferative activities (Zhang et al, 2009), as well as effective inhibition of some bacterial pathogens (Engels et al, 2009), to the authors knowledge, this is the first report on the antitumor and antimicrobial activities of decoctions and infusions of chestnut flowers of the most important cultivars in the European market, Judia and Longal.…”

Section: Introductionmentioning

confidence: 85%

Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices

Carocho

Calhelha

Queiroz

et al. 2014

Industrial Crops and Products

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Chestnut trees are one of the most important crops in the North-eastern part of Portugal, representing millions of euros of yearly income. There are many ancestral claims of the health benefits of the consumption of chestnut flowers in infusions that remain unproven. In this manuscript, the antitumor and antimicrobial potential of chestnut flowers from two cultivars, Judia and Longal, extracted through infusions and decoctions are reported. In terms of antitumor activity, the most sensitive cell lines were HepG2 and HCT15 with the cultivar Judia showing higher activity for HCT15 and Longal for HepG2, regardless of the extraction methods. Regarding the antibacterial activity of the extracts, decoctions proved to be more effective with lower minimum inhibition concentrations, while infusions were better in terms of antifungal activity.The good overall antimicrobial activity could justify the inclusion of the flowers in food chain processing to act as a natural antimicrobial. Furthermore, the results corroborate some of the ancestral claims of the consumption of these flowers.

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Section: Introductionmentioning

confidence: 85%

Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices

Carocho

Calhelha

Queiroz

et al. 2014

Industrial Crops and Products

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“…Mango (Mangifera indica L.) contains gallotannins with degrees of galloylation ranging from 4 to 12 (6,15,16). Gallotannin-rich plant extracts and penta-O-galloylglucose exhibit antibacterial activity (1,10,25) which is remarkably selective.…”

mentioning

confidence: 99%

Inhibitory Spectra and Modes of Antimicrobial Action of Gallotannins from Mango Kernels (Mangifera indicaL.)

Engels

Schieber

Gänzle

2011

Appl Environ Microbiol

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115

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This study investigated the antimicrobial activities and modes of action of penta-, hexa-, hepta-, octa-, nona-, and deca-O-galloylglucose (gallotannins) isolated from mango kernels. The MICs and minimum bactericidal concentrations (MBCs) against food-borne bacteria and fungi were determined using a critical dilution assay. Gram-positive bacteria were generally more susceptible to gallotannins than were Gram-negative bacteria. The MICs of gallotannins against Bacillus subtilis, Bacillus cereus, Clostridium botulinum, Campylobacter jejuni, Listeria monocytogenes, and Staphylococcus aureus were 0.2 g liter ؊1 or less; enterotoxigenic Escherichia coli and Salmonella enterica were inhibited by 0.5 to 1 g liter ؊1 , and lactic acid bacteria were resistant. The use of lipopolysaccharide mutants of S. enterica indicated that the outer membrane confers resistance toward gallotannins. Supplementation of LB medium with iron eliminated the inhibitory activity of gallotannins against Staphylococcus aureus, and siderophore-deficient mutants of S. enterica were less resistant toward gallotannins than was the wild-type strain. Hepta-O-galloylglucose sensitized Lactobacillus plantarum TMW1.460 to hop extract, indicating inactivation of hop resistance mechanisms, e.g., the multidrug resistance (MDR) transporter HorA. Carbohydrate metabolism of Lactococcus lactis MG1363, a conditionally respiring organism, was influenced by hepta-O-galloylglucose when grown under aerobic conditions and in the presence of heme but not under anaerobic conditions, indicating that gallotannins influence the respiratory chain. In conclusion, the inhibitory activities of gallotannins are attributable to their strong affinity for iron and likely additionally relate to the inactivation of membrane-bound proteins.

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“…Aqueous extract of M. indica inhibited the growth of S. aureus and Proteus vulgaris [25]. Gallotannins were extracted from M. indica kernels with aqueous acetone and purified using analytical high-performance liquid chromatography and mass spectrometry confirmed the presence of hydrolyzable tannins with a degree of galloylation ranging from 4 to 9 and additionally revealed the presence of deca-, undeca-, and dodeca-O-galloylglucose with antibacterial activity, as evidenced from the agar spot and critical dilution assays [26][27][28].…”

Section: Discussionmentioning

confidence: 92%

Anti-enteric bacterial activity of the traditional medicinal plants of Kanyakumari coast, Tamilnadu, India

Rajan¹,

Suvetha²,

Thirunalasundari³

et al. 2015

J Coast Life Med

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Antimicrobial Activity of Gallotannins Isolated from Mango (Mangifera indica L.) Kernels

Cited by 138 publications

References 34 publications

Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices

Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices

Inhibitory Spectra and Modes of Antimicrobial Action of Gallotannins from Mango Kernels (Mangifera indicaL.)

Anti-enteric bacterial activity of the traditional medicinal plants of Kanyakumari coast, Tamilnadu, India

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