Antimicrobial activity of herbal medicines (tulsi extract, neem extract) and chlorhexidine against Enterococcus faecalis in Endodontics: An in vitro study

Chandrappa, Pradeep M; Dupper, Akash; Tripathi, Pankaj; Arroju, Ramakrishna; Sharma, Preeti; Sulochana, Konthoujam

doi:10.4103/2231-0762.172952

Cited by 23 publications

(3 citation statements)

References 7 publications

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“…Mature dried Ocimum sanctum leaves were collected from garden of Inderprastha Dental College and Hospital [4]. Then powdering of dried leaves was done followed by masceration of powder with 100% ethanol.…”

Section: Preparation Of 10% Ocimum Sanctum (Tulsi Extract)mentioning

confidence: 99%

Comparative evaluation of fracture resistance among conventional versus herbal irrigants in root canal treated teeth: In vitro study

et al. 2023

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To evaluate the efficacy of conventional irrigants and herbal extracts materials which helps to resist fracture of endodontically treated teeth. 75 maxillary human permanent incisor teeth instrumented using ProTaper rotary files till apical size(F4). Instrumented samples divided into 5 groups with n = 15 based on various irrigants used. Group I: normal saline, Group II: 5% sodium hypochlorite (NaOCl), Group III: 2% chlorohexidine, Group IV: 10% Azadirachta indica (neem extract) and Group V: 10% Ocimum sanctum (tulsi extract).After that, root canals were proceeded to be filled by using single gutta‐percha cone and Sealapex sealer. Specimens were then prepared and loaded until root fracture occurred. Maximum mean flexural strength of dentin (fracture resistance) was obtained from group treated with 2% chlorohexidine and 10% neem extract. Least fracture resistance was observed with 5% NaOCl. Herbal irrigants can be used as an alternative to NaOCl as they exhibit high fracture resistance.

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Section: Preparation Of 10% Ocimum Sanctum (Tulsi Extract)mentioning

confidence: 99%

Comparative evaluation of fracture resistance among conventional versus herbal irrigants in root canal treated teeth: In vitro study

et al. 2023

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“…Despite this, there is a gap in understanding their efficacy in endodontics against E. faecalis [7]. This study aims to compare A. indica AgNPs to TSC AgNPs, evaluating their antimicrobial and cytotoxic effectiveness specifically against E. faecalis, addressing this crucial research gap [8].…”

Section: Introductionmentioning

confidence: 99%

“…faecalis, renowned for its tenacity and endurance within endodontic environments, poses a significant challenge during root canal treatments. Moreover, the coexistence of other microorganisms such as Candida albicans and Klebsiella pneumoniae further complicates these infections, highlighting the pressing need for novel and potent intracanal irrigants [8]. The assessment of their antimicrobial efficacy, along with cytotoxicity evaluations, aims to ascertain their safety and effectiveness as a potential therapeutic option in root canal treatments.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Evaluation of Antimicrobial and Cytotoxic Efficacy of Biosynthesized Silver Nanoparticles and Chemically Synthesized Silver Nanoparticles Against Enterococcus faecalis: An In Vitro Study

Chandran,

Ramesh,

Shanmugam

et al. 2024

Cureus

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IntroductionEffective root canal cleaning and sealing are essential for a successful endodontic procedure. For the purpose of disinfecting root canals, both herbal and non-herbal medications are recommended. This study aimed to analyze the antimicrobial and cytotoxic properties of biosynthesized silver nanoparticles (AgNPs) synthesized from Azadirachta indica/neem and chemically synthesized AgNPs from trisodium citrate (TSC) against oral pathogens to be further used as an irrigant in endodontic treatment. Materials and methodsTo synthesize A. indica AgNPs, powdered fresh A. indica leaves were weighed, added to double distilled water, heated for 30 minutes, and then combined with silver nitrate solution. TSC was also used to create TSC AgNPs. X-ray diffraction (XRD), scanning electron microscopy (SEM), ocular observation, and the ultraviolet-visible light (UV-vis) spectrum were used to characterize the AgNPs. Studies were conducted on the extract's characteristics, including its cytotoxicity and antibacterial activity. ResultsThe hue shift and peak on the UV-vis spectrophotometer were signs that AgNPs were forming. The XRD pattern showed that the sample included crystalline AgNPs, mostly spherical ones. By using SEM, the presence of AgNPs was also verified. AgNPs that were synthesized showed antimicrobial efficacy against Enterococcus faecalis. Compared to chemically synthesized AgNPs, A. indica AgNPs showed lower minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values, a bigger zone of inhibition (ZOI), and less cytotoxic action. ConclusionThis study demonstrates the minimal cytotoxicity and antibacterial activity of A. indica AgNPs against E. faecalis. This suggests that they might also be employed as root canal cleaners. Before experimenting with animals or cell lines in clinical trials for endodontic treatment, further research should be done.

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Azadirachta indica(Neem)

Tanguturi

Gunupati

Nagarakanti

2020

Natural Oral Care in Dental Therapy

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Antimicrobial activity of herbal medicines (tulsi extract, neem extract) and chlorhexidine against Enterococcus faecalis in Endodontics: An in vitro study

Cited by 23 publications

References 7 publications

Comparative evaluation of fracture resistance among conventional versus herbal irrigants in root canal treated teeth: In vitro study

Comparative evaluation of fracture resistance among conventional versus herbal irrigants in root canal treated teeth: In vitro study

A Comparative Evaluation of Antimicrobial and Cytotoxic Efficacy of Biosynthesized Silver Nanoparticles and Chemically Synthesized Silver Nanoparticles Against Enterococcus faecalis: An In Vitro Study

Azadirachta indica(Neem)

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