2024
DOI: 10.2217/fmb-2023-0160
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Antimicrobial Activity of Hydralazine Against Methicillin-Resistant and Methicillin-SusceptibleStaphylococcus Aureus

Francisca B Stefany Aires do Nascimento,
Lívia Gurgel do Amaral Valente Sá,
João B de Andrade Neto
et al.

Abstract: Background: Staphylococcus aureus is a human pathogen responsible for high mortality rates. The development of new antimicrobials is urgent. Materials & methods: The authors evaluated the activity of hydralazine along with its synergism with other drugs and action on biofilms. With regard to action mechanisms, the authors evaluated cell viability, DNA damage and molecular docking. Results: MIC and minimum bactericidal concentration values ranged from 128 to 2048 μg/ml. There was synergism with oxacillin (5… Show more

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