Antimicrobial activity of hydroxytyrosol: a current controversy

Medina-Martínez, María S.; Truchado, Pilar; Castro-Ibáñez, Irene; Allende, Ana

doi:10.1080/09168451.2015.1116924

Cited by 47 publications

(33 citation statements)

References 35 publications

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“…Hydroxytyrosol (HT), 3,4-dihydroxy phenethyl alcohol, is an important active compound in olive oil and olive leaf [ 1 , 2 ]. Small-molecule HT contains three free hydroxyl groups and presents strong bioactivity, such as antioxidant [ 3 , 4 ], antimicrobial [ 5 , 6 ], and anti-inflammatory properties [ 7 ], in addition to antitumor activity to inhibit the proliferation of human promyelocytic leukemia HL60 cells [ 8 ], human colon cancer HT-29 cells [ 9 ], and MCF-7 human breast cancer cells [ 10 ]. Many works have reported on the HT chemical structure and derivatives [ 11 , 12 ], antitumor activity and mechanism [ 13 ], and pharmacokinetics [ 14 ] for anticancer drugs or cancer adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

Thermal Decomposition Behavior of Hydroxytyrosol (HT) in Nitrogen Atmosphere Based on TG-FTIR Methods

Yuan

2018

Molecules

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The thermal decomposition behavior of olive hydroxytyrosol (HT) was first studied using thermogravimetry (TG). Cracked chemical bond and evolved gas analysis during the thermal decomposition process of HT were also investigated using thermogravimetry coupled with infrared spectroscopy (TG-FTIR). Thermogravimetry-Differential thermogravimetry (TG-DTG) curves revealed that the thermal decomposition of HT began at 262.8 °C and ended at 409.7 °C with a main mass loss. It was demonstrated that a high heating rate (over 20 K·min−1) restrained the thermal decomposition of HT, resulting in an obvious thermal hysteresis. Furthermore, a thermal decomposition kinetics investigation of HT indicated that the non-isothermal decomposition mechanism was one-dimensional diffusion (D1), integral form g(x) = x2, and differential form f(x) = 1/(2x). The four combined approaches were employed to calculate the activation energy (E = 128.50 kJ·mol−1) and Arrhenius preexponential factor (ln A = 24.39 min−1). In addition, a tentative mechanism of HT thermal decomposition was further developed. The results provide a theoretical reference for the potential thermal stability of HT.

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Section: Introductionmentioning

confidence: 99%

Thermal Decomposition Behavior of Hydroxytyrosol (HT) in Nitrogen Atmosphere Based on TG-FTIR Methods

Yuan

2018

Molecules

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“…Olive leaf contains a wide variety of phenolic compounds (Yuan, ), for example, oleuropein (OL), hydroxytyrosol (HT), tyrosol, cumaric acid, ferulic acid, caffeic acid, etc. In particular, small molecule HT presents strong bioactivity, such as antioxidant (Owen, Giacosa, Hull, Haubner, Spiegelhalder, & Bartsch, ; Visioli et al, ), antimicrobial (Bisignano et al, ; Medinamartínez, Truchado, Castroibáñez, & Allende, ), anti‐inflammatory (Killeen, Pontoniere, & Crea, ), antitumor to inhibit proliferation of human promyelocytic leukemia HL60 cells (Fabiani et al, ), human colon cancer HT‐29 cells (Bernini et al, ), and MCF‐7 human breast cancer cells (Bouallagui, Han, Isoda, & Sayadi, ). Many works were reported on HT preparation from natural plant separation and chemical synthesis, but HT yield was very low, and it also need a large amount of toxic agents, expensive catalysts, and long time.…”

Section: Introductionmentioning

confidence: 99%

Phenolic composition of oleuropein extract after enzymatic process by HPLC-MS and their antioxidant and antibacterial activities

Yuan

Qin

et al. 2018

J Food Biochem

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Oleuropein is an antioxidant olive constituent, but it is liable to degrade into hydroxytyrosol. Oleuropein extract was hydrolyzed by hemicellulase and the results presented that 14 phenols were identified in the ethyl acetate extract of enzymatic hydrolysate by HPLC-MS. Antioxidant activities (DPPH, ABTS, total reducing power, FRAP, and Fe 21 chelating ability) of phenols were all added with the samples concentration increased, and dose-effect relationship also existed. 14 phenols all possessed certain inhibition effect against selected bacteria, and they had better inhibition effect against tested Gram-positive bacterium (Staphylococcus aureus) than Gram-negative bacterium (Escherichia coli). Finally, hydroxytyrosol, oleuropein, eugenol, caffeic acid, and 3,4-dihydroxybenzoic acid could present excellent antioxidant and antibacterial effect, and the two activities mainly had close relationship. Practical applicationsFrom the previous study we could know enzymatic biotransformation from oleuropein to HT was a promising method. Therefore, HT preparation from enzyme has attracted great attention of researcher. If that, a lot of enzymatic hydrolysate would be produced in the process. So, present study was to use fully the ethyl acetate extract of enzymatic hydrolysate, and to determine the chemical composition of phenolic compounds in EAE by HPLC-MS, and to evaluate their antioxidant and antimicrobial capacity. The result was shown that phenols of oleuropein extract after enzymatic process, therefore, may be suitable as a source of powerful antioxidants and bacteriostatic due to their stronger antioxidant and antibacterial activities. They could be widely applied in functional food industry for preservation.

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“…One study reported the antiaging effect of HT [ 41 ]. Three studies focused on investigating the antimicrobial effect of HT [ 42 , 43 , 44 ]. Moreover, eight studies also included the anti-inflammatory effect of HT as a supplementary outcome of their studies [ 32 , 33 , 34 , 35 , 38 , 39 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

Molecular Action of Hydroxytyrosol in Wound Healing: An In Vitro Evidence-Based Review

et al. 2020

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Hydroxytyrosol (HT) is an essential molecule isolated from the phenolic fraction of olive (Olea europaea). HT has been implicated for its health-stimulating effect mainly due to its antioxidative capacity. The current review summarises and discusses the available evidence, related to HT activities in wound healing enhancement. The literature search of related articles published within the year 2010 to 2020 was conducted using Medline via Ebscohost, Scopus, and Google Scholar databases. Studies were limited to in vitro research regarding the role of HT in wound closure, including anti-inflammation, antimicrobial, antioxidative, and its direct effect to the cells involved in wound healing. The literature search revealed 7136 potentially relevant records were obtained from the database search. Through the screening process, 13 relevant in vitro studies investigating the role of HT in wound repair were included. The included studies reported a proangiogenic, antioxidative, antiaging, anti-inflammatory and antimicrobial effect of HT. The current in vitro evidence-based review highlights the cellular and molecular action of HT in influencing positive outcomes toward wound healing. Based on this evidence, HT is a highly recommended bioactive compound to be used as a pharmaceutical product for wound care applications.

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Antimicrobial activity of hydroxytyrosol: a current controversy

Cited by 47 publications

References 35 publications

Thermal Decomposition Behavior of Hydroxytyrosol (HT) in Nitrogen Atmosphere Based on TG-FTIR Methods

Thermal Decomposition Behavior of Hydroxytyrosol (HT) in Nitrogen Atmosphere Based on TG-FTIR Methods

Phenolic composition of oleuropein extract after enzymatic process by HPLC-MS and their antioxidant and antibacterial activities

Molecular Action of Hydroxytyrosol in Wound Healing: An In Vitro Evidence-Based Review

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