Antimicrobial activity of limonene: Integrative review

Ribeiro, Adyelle Dantas; Cardoso, Maria do Socorro de Lucena; Freire, Julliana Cariry Palhano; Júnior, Ernani Canuto Figueirêdo; Costa, Mariana Mélani Alexandrino; Vasconcelos, Priscilla Guimarães Silva; Gomes, Daliana Queiroga de Castro; Costa, Edja Maria Melo de Brito; Pereira, Jozinete Vieira

doi:10.37360/blacpma.23.22.5.42

Cited by 6 publications

(1 citation statement)

References 47 publications

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“…The terpenoid limonene displays antitumoral, antimicrobial, antifungal, antidiabetic, anti-inflammatory, antiallergenic, antitumoral (breast tumor), and neuroprotective activities [ 66 , 67 ].…”

Section: Resultsmentioning

confidence: 99%

Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation

Segneanu,

Vlase,

Vlase

et al. 2024

Plants

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Novel nanotechnology based on herbal products aspires to be a high-performing therapeutic platform. This study reports the development of an original engineering carrier system that jointly combines the pharmacological action of Chelidonium majus and AuNPs, with unique properties that ensure that the limitations imposed by low stability, toxicity, absorption, and targeted and prolonged release can be overcome. The metabolite profile of Romanian wild-grown Chelidonium majus contains a total of seventy-four phytochemicals belonging to eight secondary metabolite categories, including alkaloids, amino acids, phenolic acids, flavonoids, carotenoids, fatty acids, sterols, and miscellaneous others. In this study, various techniques (XRD, FTIR, SEM, DLS, and TG/DTG) were employed to investigate his new carrier system’s morpho-structural and thermal properties. In vitro assays were conducted to evaluate the antioxidant potential and release profile. The results indicate 99.9% and 94.4% dissolution at different pH values for the CG-AuNPs carrier system and 93.5% and 85.26% for greater celandine at pH 4 and pH 7, respectively. Additionally, three in vitro antioxidant assays indicated an increase in antioxidant potential (flavonoid content 3.8%; FRAP assay 24.6%; and DPPH 24.4%) of the CG-AuNPs carrier system compared to the herb sample. The collective results reflect the system’s promising perspective as a new efficient antimicrobial and anti-inflammatory candidate with versatile applications, ranging from target delivery systems, oral inflammation (periodontitis), and anti-age cosmetics to extending the shelf lives of products in the food industry.

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Section: Resultsmentioning

confidence: 99%