Antimicrobial activity of magainin analogues against anaerobic oral pathogens

Genco, Caroline Attardo; Maloy, W L; Kari, U. Prasad; Motley, Milwood

doi:10.1016/s0924-8579(02)00275-3

Cited by 24 publications

(9 citation statements)

References 21 publications

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“…Other examples of activity of magainin-2 and its analogues against important human pathogens include Helicobacter pylori [53], Salmonella typhimurium [54], the anaerobic periodontal pathogens, Porphyromonas gingivalis , Fusobacterium nucleatum , and Prevotella loeschei [55], and Acanthamoeba polyphagia , a protozooan responsible for ocular infection in contact lens wearers [56]. …”

Section: Peptides With Antimicrobial Activitymentioning

confidence: 99%

Host-Defense Peptides with Therapeutic Potential from Skin Secretions of Frogs from the Family Pipidae

Conlon

Mechkarska

2014

Pharmaceuticals

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Skin secretions from frogs belonging to the genera Xenopus, Silurana, Hymenochirus, and Pseudhymenochirus in the family Pipidae are a rich source of host-defense peptides with varying degrees of antimicrobial activities and cytotoxicities to mammalian cells. Magainin, peptide glycine-leucine-amide (PGLa), caerulein-precursor fragment (CPF), and xenopsin-precursor fragment (XPF) peptides have been isolated from norepinephrine-stimulated skin secretions from several species of Xenopus and Silurana. Hymenochirins and pseudhymenochirins have been isolated from Hymenochirus boettgeri and Pseudhymenochirus merlini. A major obstacle to the development of these peptides as anti-infective agents is their hemolytic activities against human erythrocytes. Analogs of the magainins, CPF peptides and hymenochirin-1B with increased antimicrobial potencies and low cytotoxicities have been developed that are active (MIC < 5 μM) against multidrug-resistant clinical isolates of Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, Stenotrophomonas maltophilia and Klebsiella pneumoniae. Despite this, the therapeutic potential of frog skin peptides as anti-infective agents has not been realized so that alternative clinical applications as anti-cancer, anti-viral, anti-diabetic, or immunomodulatory drugs are being explored.

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Section: Peptides With Antimicrobial Activitymentioning

confidence: 99%

Host-Defense Peptides with Therapeutic Potential from Skin Secretions of Frogs from the Family Pipidae

Conlon

Mechkarska

2014

Pharmaceuticals

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“…PGLa is reported to reduce pure cultures of S. mutans, S. sanguis, and A. naeslundii by 99.9% after 30-min exposure to 100 lg/mL concentrations, which is comparable with histatin-Dhvar4, but unlike Dhvar4, no significant reduction is observed against multispecies biofilm [81]. The reported activity against cariogenic bacteria for both magainin 2 and PGLa is moderate; however, magainin 2 is also active against pathogens associated with periodontal disease, including P. gingivalis [63]. Accordingly, magainins may be useful for the promotion of overall oral health.…”

Section: Amphibian-derived Antimicrobial Peptidesmentioning

confidence: 80%

Antibacterial Peptides: Opportunities for the Prevention and Treatment of Dental Caries

Pepperney

Chikindas

2011

Probiotics & Antimicro. Prot.

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Dental caries is a multifactorial disease that is a growing and costly global health concern. The onset of disease is a consequence of an ecological imbalance within the dental plaque biofilm that favors specific acidogenic and aciduric caries pathogens, namely Streptococcus mutans and Streptococcus sobrinus. It is now recognized by the scientific and medical community that it is neither possible nor desirable to totally eliminate dental plaque. Conversely, the chemical biocides most commonly used for caries prevention and treatment indiscriminately attack all plaque microorganisms. These treatments also suffer from other drawbacks such as bad taste, irritability, and staining. Furthermore, the public demand for safe and natural personal hygiene products continues to rise. Therefore, there are opportunities that exist to develop new strategies for the treatment of this disease. As an alternative to conventional antibiotics, antibacterial peptides have been explored greatly over the last three decades for many different therapeutic uses. There are currently tens of hundreds of antibacterial peptides characterized across the evolutionary spectrum, and among these, many demonstrate physical and/or biological properties that may be suitable for a more targeted approach to the selective control or elimination of putative caries pathogens. Additionally, many peptides, such as nisin, are odorless, colorless, and tasteless and do not cause irritation or staining. This review focuses on antibacterial peptides for their potential role in the treatment and prevention of dental caries and suggests candidates that need to be explored further. Practical considerations for the development of antibacterial peptides as oral treatments are also discussed.

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“…MSI-78 (trade name: Pexiganan) is a synthetic amphipathic, a-helical peptide magainin derivative antibiotic, containing 22 amino acid residues (134). MSI-78 has antimicrobial activity against local infections caused by both Gram-positive and Gram-negative bacteria, including some infections caused by pathogens resistant to conventional antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial peptides from amphibians

Xiao

Liu

Lai

2011

BioMolecular Concepts

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Increased prevalence of multi-drug resistance in pathogens has encouraged researchers to focus on finding novel forms of anti-infective agents. Antimicrobial peptides (AMPs) found in animal secretions are components of host innate immune response and have survived eons of pathogen evolution. Thus, they are likely to be active against pathogens and even those that are resistant to conventional drugs. Many peptides have been isolated and shown to be effective against multi-drug resistant pathogens. More than 500 AMPs have been identified from amphibians. The abundance of AMPs in frog skin is remarkable and constitutes a rich source for design of novel pharmaceutical molecules. Expression and post-translational modifications, discovery, activities and probable therapeutic application prospects of amphibian AMPs will be discussed in this article.

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Antimicrobial activity of magainin analogues against anaerobic oral pathogens

Cited by 24 publications

References 21 publications

Host-Defense Peptides with Therapeutic Potential from Skin Secretions of Frogs from the Family Pipidae

Host-Defense Peptides with Therapeutic Potential from Skin Secretions of Frogs from the Family Pipidae

Antibacterial Peptides: Opportunities for the Prevention and Treatment of Dental Caries

Antimicrobial peptides from amphibians

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