Antimicrobial activity of medicinal plants against oral microorganisms

More, Garland Kgosi; Tshikalange, Thilivhali Emmanuel; Lall, Namrita; Botha, Francien Susanna; Meyer, J.J.M.

doi:10.1016/j.jep.2008.07.001

Cited by 135 publications

(102 citation statements)

References 16 publications

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“…The cytotoxicity of plants, extracts, fractions, and isolated compounds has often been reported to depend on concentration and contact time (Gursoy et al, 2009;Vargas et al, 2010). This toxicity is many times moderate (More et al, 2008;Signoretto et al, 2011) or even uncapable of causing deleterious effects (Seneviratne et al, 2011), but further drug safety assessment is essential before diterpenes of the pimarane type are introduced into the market for use in humans.…”

Section: Discussionmentioning

confidence: 99%

Diterpenes of the pimarane type isolated from Viguiera arenaria: Promising in vitro biological potential as therapeutic agents for endodontics

Marangoni¹,

Moraes²,

Utrera³

et al. 2018

J. Pharmacognosy Phytother.

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Viguiera arenaria, family Asteraceae, is a plant that contains diterpenoids, which make this species potentially applicable in endodontics. More specifically, V. arenaria contains diterpenes of the pimarane type, which display various classic biological activities. This study evaluates the antibiofilm activity, the time-kill curve, and the inhibitory concentration index of diterpenes of the pimarane type (entpimara-8(14),15-dien-19-oic acid, ent-8(14),15-pimaradien-3β-ol, and ent-8(14),15-pimaradien-3β-19-oic acid sodium salt, designated diterpenes I, II, and III, respectively) toward nine anaerobic bacteria commonly found in endodontic infections; this study also assesses the cytotoxic activity of these diterpenes against human fibroblasts. According to the antibiofilm assay, diterpenes I, II, and III inhibit at least 50% of all the bacteria. On the basis of the time-kill curve experiments, the behavior of these diterpenes depends on the tested bacteria, diterpene concentration, and microorganism sensitivity. Synergism of diterpenes I and II with chlorhexidine (CDH) was higher against P. gingivalis (clinical isolate) and Aggregatibacter actinomycetemcomitans (ATCC). As for diterpene III, synergism with CDH is higher against P. micros. As revealed by the XTT assay, none of the diterpenes of the pimarane type tested here are cytotoxic. Hence, diterpenes I, II, and III are promising biomolecules and may provide therapeutic solutions in the field of endodontics.

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Section: Discussionmentioning

confidence: 99%

Diterpenes of the pimarane type isolated from Viguiera arenaria: Promising in vitro biological potential as therapeutic agents for endodontics

Marangoni¹,

Moraes²,

Utrera³

et al. 2018

J. Pharmacognosy Phytother.

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“…Then, samples were washed in tap and distilled water, and dried at room temperature for 1-2 weeks [15]. Plant extracts were prepared according to the methods described by Elibol et al [22] and More et al [23], with slight modifications. Air-dried plant material (50 g) was extracted with 96% ethanol for 4 days at a room temperature.…”

Section: Extract Preparationmentioning

confidence: 99%

Antibacterial activity of ethanolic extracts of some moss species

Karpiński

Adamczak

2017

Herba Polonica

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Summary Introduction: For centuries, mosses have been used in traditional medicine due to their antibacterial, antifungal, and antiviral activities. Objective: The present study was designed to evaluate the antibacterial activity of ethanolic extracts obtained from 12 moss species: Brachythecium albicans, Bryum argenteum, Ceratodon purpureus, Dicranum scoparium, Dryptodon pulvinatus, Orthotrichum anomalum, Oxyrrhynchium hians, Plagiomnium undulatum, Polytrichum juniperinum, P. piliferum, Schistidium crassipilum, and Syntrichia ruralis. Methods: The antimicrobial activity of extracts was investigated against three Gram(+) bacteria (Enterococcus faecalis, Staphylococcus aureus, and Streptococcus pyogenes) and two Gram(-) bacteria (Escherichia coli and Klebsiella pneumoniae), using the agar disc-diffusion method. Results: The high activity against all investigated bacteria was determined for extracts of D. pulvinatus, P. undulatum, B. argenteum, S. crassipilum, O. anomalum (mean inhibition zone: 11.3-13.1 mm) and to a lesser extent in the case of D. scoparium (8.3 mm). Extracts from P. juniperinum and P. piliferum showed activity only against Gram-positive bacteria, with an inhibition zone from 7.3 to 9.7 mm. Four species: B. albicans, C. purpureus, O. hians, and S. ruralis had not antibacterial properties. Conclusions: The obtained results indicate that mosses could be a significant source of antibacterial agents. For the first time, we presented antibacterial activity of ethanolic extracts from S. crassipilum and O. anomalum.

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“…Its frequent and prolonged use presents many collateral effects, such as changes in the taste of food and a burning feeling on the tip of the tongue (Greenberg et al, 2008;More et al, 2008;Porto et al, 2009).…”

Section: Biofilm Resistance and Antimicrobial Measuresmentioning

confidence: 99%

Antibiofilm activity of natural substances derived from plants

Nogueira¹,

Costa²,

Cunha³

et al. 2017

Afr. J. Microbiol. Res.

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The main objective of this study was to conduct a review of bioactive substances derived from plants which show antimicrobial/antibiofilm properties. Vegetable species were widely employed as ingredients in medicine based on traditional knowledge. Various secondary metabolites have been proven to inhibit bacterial growth. Bacterial resistance mechanisms have increased over the years. Biofilms are types of bacterial association which gives the communities a higher resistance to drugs. The formation process of biofilms, the problems caused by them and the natural substances, as well as their main chemical components and action mechanisms, have been described according to existing literature.

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Antimicrobial activity of medicinal plants against oral microorganisms

Cited by 135 publications

References 16 publications

Diterpenes of the pimarane type isolated from Viguiera arenaria: Promising in vitro biological potential as therapeutic agents for endodontics

Diterpenes of the pimarane type isolated from Viguiera arenaria: Promising in vitro biological potential as therapeutic agents for endodontics

Antibacterial activity of ethanolic extracts of some moss species

Antibiofilm activity of natural substances derived from plants

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