Antimicrobial activity of metal oxide microspheres: an innovative process for homogeneous incorporation into materials

Feuillolay, Catherine; Haddioui, L.; Verelst, Marc; Furiga, Aurélie; Marchin, Loïc; Roques, Christine

doi:10.1111/jam.13752

Cited by 7 publications

(9 citation statements)

References 38 publications

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“…The experiment was carried out for 2 h. The dark MVO (MVO powder in the absence of light) showed antibacterial activity, reducing the bacterial count by an order. This phenomenon of ceramic powder inherently exhibiting antibacterial activity has been reported. − In the presence of light, MVO powder exhibited a drop in bacterial count by 3 orders of magnitude, establishing enhanced antibacterial activity in the presence of ambient light at an intensity of 9000 lux ( p < 0.001) (Figure e). These results of MVO powder provide a new avenue to apply MVO as an antibacterial material.…”

Section: Results and Discussionsupporting

confidence: 68%

Ambient Light-Activated Antibacterial Material: Manganese Vanadium Oxide (Mn₂V₂O₇)

Singh

Hegde

Ravindra

et al. 2021

ACS Appl. Bio Mater.

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Antimicrobial surfaces can reduce the spread of bacteria from high-touch surfaces, saving millions of lives worldwide. Antibacterial photocatalytic films, like TiO2, are widely reported but limited in practice because they need high-intensity UV light. More practical but less reported are photocatalysts that work under low-intensity visible light from an indoor lamp. Here, we demonstrate that manganese vanadium oxide (MVO) is an antibacterial photocatalyst that works under light-emitting diode (LED) lights at ∼3000 lux. MVO is an earth-abundant semiconductor with a band gap of 1.7 eV that absorbs visible light to create reactive oxygen species (ROS) in water. ROS reduces bacteria counts by 4 orders of magnitude in 8 h under 9000 lux LED light. The antibacterial effect is significant even in MVO powder and films, which are amenable to large-area fabrication. MVO is a promising candidate for next-generation antimicrobial coatings that are stable, cheap, effective, earth-abundant, and activated by indoor lights.

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Section: Results and Discussionsupporting

confidence: 68%

Ambient Light-Activated Antibacterial Material: Manganese Vanadium Oxide (Mn₂V₂O₇)

Singh

Hegde

Ravindra

et al. 2021

ACS Appl. Bio Mater.

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“…Even though poorly documented, these hospital-prepared formulations presented high risks of contamination, ranging between 8.4% [ 37 ],16.7% [ 40 ], 24.06% [ 17 ], and 28.9% [ 12 ] ( Table 3 ). Currently, new packaging designs are being evaluated and proposed to limit the risk of microbial migration to the eye-drop contents and the viability of contaminants on caps and tips [ 12 , 81 , 82 , 83 ].…”

Section: Resultsmentioning

confidence: 99%

“…This technology consists of a self-decontaminating dropper tips and caps that are mercury- and metal-free. This technology incorporates mineral microspheres into any plastic resins (tip and cap of a multi-dose container) to exert a disruptive antimicrobial effect without causing an allergic reaction or patient harm [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

Highlighting the Microbial Contamination of the Dropper Tip and Cap of In-Use Eye Drops, the Associated Contributory Factors, and the Risk of Infection: A Past-30-Years Literature Review

Iskandar

Marchin²,

Kodjikian

et al. 2022

Pharmaceutics

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The sterility of eye drop content is a primary concern from manufacturing until opening, as well as during handling by end users, while microbial contamination of the dropper tip and cap are often disregarded. The contamination of these sites during drug administration represents a risk of microbial transmission and ocular infection. In this review, we aim to assess microbial contamination of the dropper tip and cap of in-use eye drops, the associated contributory factors, and the risk of infection. We conducted a literature search of the MEDLINE, PubMed, and Cochrane Central databases. A total of 31 out of 1503 studies were selected. All the studies conducted in different settings that documented microbiologically contaminated in-use eye drops were included. Our review showed that microbial contamination of the dropper tip and cap of in-use eye drops ranged from 7.7 to 100% of the total contaminated tested samples. Documented contributory factors were conflicting across the literature. Studies investigating the association between eye infection and microbial contamination of the dropper tip and cap were scarce. New technologies offer a promising potential for securing the long-term sterility of eye drop content, tips, and caps, which could benefit from more research and well-defined study protocols under real-life scenarios.

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“…Antimicrobial surfaces are based on technologies that either repel or kill microorganisms when applied to a surface [ 22 ]. The field of possible applications of such technologies is wide and still growing [ 23 ]. A French national organization for standardization/ Association Française de Normalisation (AFNOR) efficacy standard (NF S 90-700) has been published in 2019 and is the basis for what will become the ISO standard.…”

Section: Introductionmentioning

confidence: 99%

New frontiers in healthcare environmental hygiene: thoughts from the 2022 healthcare cleaning forum

Peters

Parneix

Kiernan

et al. 2023

Antimicrob Resist Infect Control

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Healthcare environmental hygiene (HEH) has become recognized as being increasingly important for patient safety and the prevention of healthcare-associated infections. At the 2022 Healthcare Cleaning Forum at Interclean in Amsterdam, the academic lectures focused on a series of main areas of interest. These areas are indicative of some of the main trends and avenues for research in the coming years. Both industry and academia need to take steps to continue the momentum of HEH as we transition out of the acute phase of the Covid-19 pandemic. There is a need for new ways to facilitate collaboration between the academic and private sectors. The Clean Hospitals® network was presented in the context of the need for both cross-disciplinarity and evidence-based interventions in HEH. Governmental bodies have also become more involved in the field, and both the German DIN 13603 standard and the UK NHS Cleaning Standards were analyzed and compared. The challenge of environmental pathogens was explored through the example of how P. aeruginosa persists in the healthcare environment. New innovations in HEH were presented, from digitalization to tracking, and automated disinfection to antimicrobial surfaces. The need for sustainability in HEH was also explored, focusing on the burden of waste, the need for a circular economy, and trends towards increasingly local provision of goods and services. The continued focus on and expansion of these areas of HEH will result in safer patient care and contribute to better health systems.

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Antimicrobial activity of metal oxide microspheres: an innovative process for homogeneous incorporation into materials

Abstract: This is, to our knowledge, the first report on an original process incorporating metal oxide microspheres, which have specific physico-chemical and antimicrobial properties, into materials that could be used for surface contamination prevention.

Cited by 7 publications

References 38 publications

Ambient Light-Activated Antibacterial Material: Manganese Vanadium Oxide (Mn₂V₂O₇)

Ambient Light-Activated Antibacterial Material: Manganese Vanadium Oxide (Mn₂V₂O₇)

Highlighting the Microbial Contamination of the Dropper Tip and Cap of In-Use Eye Drops, the Associated Contributory Factors, and the Risk of Infection: A Past-30-Years Literature Review

New frontiers in healthcare environmental hygiene: thoughts from the 2022 healthcare cleaning forum

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Antimicrobial activity of metal oxide microspheres: an innovative process for homogeneous incorporation into materials

Abstract: This is, to our knowledge, the first report on an original process incorporating metal oxide microspheres, which have specific physico-chemical and antimicrobial properties, into materials that could be used for surface contamination prevention.

Cited by 7 publications

References 38 publications

Ambient Light-Activated Antibacterial Material: Manganese Vanadium Oxide (Mn2V2O7)

Ambient Light-Activated Antibacterial Material: Manganese Vanadium Oxide (Mn2V2O7)

Highlighting the Microbial Contamination of the Dropper Tip and Cap of In-Use Eye Drops, the Associated Contributory Factors, and the Risk of Infection: A Past-30-Years Literature Review

New frontiers in healthcare environmental hygiene: thoughts from the 2022 healthcare cleaning forum

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Product

Resources

About

Ambient Light-Activated Antibacterial Material: Manganese Vanadium Oxide (Mn₂V₂O₇)

Ambient Light-Activated Antibacterial Material: Manganese Vanadium Oxide (Mn₂V₂O₇)