Antimicrobial activity of natural products against MDR bacteria: A scientometric visualization analysis

Abstract

Objective: A growing number of studies have demonstrated the antimicrobial activity of natural products against multidrug-resistant bacteria. This study aimed to apply scientometric method to explore the current status and future trends in this field.Methods: All relevant original articles and reviews for the period 1997–2021 were retrieved from the Web of Science Core Collection database. VOSviewer, a scientometric software, and an online bibliometric analysis platform were used to conduct visualization study.Results: A total of 1,267 papers were included, including 1,005 original articles and 262 reviews. The United States and India made the largest contribution in this field. The University of Dschang from Cameroon produced the most publications. Coutinho HDM, Kuete V, and Gibbons S were key researchers, as they published a great many articles and were co-cited in numerous publications. Frontiers in Microbiology and Antimicrobial Agents and Chemotherapy were the most influential journals with the highest number of publications and co-citations, respectively. “Medicinal plants”, “methicillin-resistant Staphylococcus aureus”, “biofilm”, “minimum inhibitory concentration”, and “efflux pumps” were the most frequently used keywords, so these terms are presumed to be the current hot topics. All the included keywords could be roughly divided into four major themes, of which the theme of “natural product development approach” had attracted much attention in recent years. Furthermore, “Pseudomonas aeruginosa”, “nanoparticles”, “green synthesis”, “antimicrobial peptides”, “antibiofilm”, “biosynthetic gene clusters”, and “molecular dynamics simulation” had the latest average appearance year, indicating that these topics may become the research hot spots in the coming years.Conclusion: This study performed a scientometric analysis of the antibacterial activity of natural products against multidrug-resistant bacteria from a holistic perspective. It is hoped to provide novel and useful data for scientific research, and help researchers to explore this field more intuitively and effectively.

Network pharmacology and in vivo and in vitro experiments to determine the mechanism behind the effects of Jiawei Yanghe decoction via TLR4/Myd88/NF-κB against mastitis

“…Thus, the need for alternative therapeutic approaches for treating breast inflammation is indicated. Herbs from traditional Chinese medicine (TCM), both in formulations and as a single active ingredient, have shown low resistance to the dual regulation of a bacterium and a host by altering the permeability of biological membranes and ion channels and inhibiting bacterial enzyme activities [ [20] , [21] , [22] ]. For a more effective and early prevention and treatment of LM and to reduce its incidence and the progression of breast abscesses, the use of herbal medicines from TCM can be a potential treatment approach [ 23 , 24 ].…”

Antibacterial and Antimycotic Activity of Epilobium angustifolium L. Extracts: A Review

“…Recently, the expansion of drug-resistant pathogens has created demand for novel antimicrobials and stimulated the search for natural plant-based compounds as alternatives to synthetics [1][2][3]. Plants are a promising source of antimicrobial compounds: tannins, flavonoids, phenolic acids, essential oils, saponins, alkaloids, etc.…”