Antimicrobial activity of natural products against Helicobacter pylori: a review

Bonifácio, Bruna Vidal; Ramos, Matheus Aparecido dos Santos; Silva, Patrícia Bento da; Bauab, Taís Maria

doi:10.1186/s12941-014-0054-0

Cited by 38 publications

(39 citation statements)

References 51 publications

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“…However, the results of our research showed that the single evaluation of α-terpineol had a better anti-E. faecalis activity than the other volatiles assayed. Comparatively to our results, Bonifácio et al [14] and Miyamoto et al [15] reported the similar MIC values (50-200 μg mL À 1 ) for limonene, β-pinene, α-terpineol and α-terpinene against H. pylori ATCC 53504. Despite the slight variances of each antibacterial study, our results suggest that the natural monoterpenes could be strongly considered when designing new products for the biological control of H. pylori.…”

Section: Antimicrobial Activitysupporting

confidence: 88%

Volatile Profiling, Insecticidal, Antibacterial and Antiproliferative Properties of the Essential Oils of Bursera glabrifolia Leaves

Villa‐Ruano

Becerra‐Martínez

Durán³

et al. 2018

Chemistry & Biodiversity

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The present article describes the chemical composition and biological activities of the essential oils of B. glabrifolia leaves obtained in four consecutive years (2015-2018). The essential oils contained α-terpineol (17.9-29.7 %), α-terpinene (12.6-17.4 %), limonene (14.9-26.8 %) and β-pinene (2.1-16.7 %) as the most abundant volatiles. The essential oils and these volatiles showed a significant adulticide activity (p<0.01; LC <100 μg mL ) on the maize weevil (Sitophilus zeamais) with a 100 % mortality rate within a period of 5 h. Also, the essential oils showed a strong antibacterial activity on Enterococcus faecalis ATCC 29212 (MIC, 132.7-173.6 μg mL ) and Helicobacter pylori ATCC 43504 (MIC, 74.8-199.2 μg mL ). The assessment of the main volatiles revealed α-terpineol as the principal antibacterial agent (MIC, 78.6-149.7 μg mL ). Similarly, the essential oils exhibited a substantial in vitro antiproliferative activity on the human prostate cancer cell lines PC-3 (LC , 15.2-19.4 μg mL ), the human ovarian carcinoma cell lines OVCAR-3 (LC , 27.3-53.7 μg mL ) and the myelogenous leukemia cell lines K-562 (LC , 32.4-75.9 μg mL ). α-Terpineol (LC , 32.4-75.9 μg mL ) exhibited the strongest antiproliferative effect on these cancer cell lines (LC , 22.4-48.1 μg mL ).

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Section: Antimicrobial Activitysupporting

confidence: 88%

Volatile Profiling, Insecticidal, Antibacterial and Antiproliferative Properties of the Essential Oils of Bursera glabrifolia Leaves

Villa‐Ruano

Becerra‐Martínez

Durán³

et al. 2018

Chemistry & Biodiversity

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“…While this is due not only to an increase in the level and type of resistance that exists (Zhu et al 2013;Oz et al 2014), the overuse and misuse of antibiotics in both human and veterinary applications cannot be understated (Berendonk et al 2015;Meek et al 2015;Fleming-Dutra et al 2016) and has shifted focus towards new strategies for combatting multi-resistant infections, including reducing antibiotic consumption (Sabuncu et al 2009) and the development of new therapies (Brown and Wright 2016). Both bacteriophages and plant extracts are amongst those being investigated either as individual therapies (Bonif acio et al 2014;Semler et al 2014;Takemura-Uchiyama et al 2014) or as adjuvants to conventional antibiotics (Coulter et al 2014;Cushnie et al 2014;Kamal and Dennis 2015).…”

Section: Introductionmentioning

confidence: 99%

In vitroactivity of a combination of bacteriophages and antimicrobial plant extracts

Pimchan

Cooper

Eumkeb

et al. 2018

Lett Appl Microbiol

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Significance and Impact of Study: This preliminary study provides insights into the potential combination of bacteriophages and antimicrobial plant bulk extracts to target bacterial pathogens. It is to our knowledge the first time in which virulent bacteriophages have been combined with antimicrobial plant extracts. AbstractThe continuing threat of antimicrobial resistance presents a considerable challenge to researchers to develop novel strategies ensuring that bacterial infections remain treatable. Many plant extracts have been shown to have antibacterial properties and could potentially be combined with other antibacterial agents to create more effective formulations. In this study, the antibacterial activity of three plant extracts and virulent bacteriophages have been assessed as individual components and in combination. When assessed with a modified suspension test, these plant extracts also exhibit antiviral activity at bacterial inhibitory concentrations. Hence, to investigate any potential additive effects between the extracts and virulent phages, the extracts were tested at subantiviral concentrations. Phages alone and in combination with plant extracts significantly reduced (P < 0Á05) the bacterial concentration compared to untreated and extract treated controls up to 6 h (2-3log 10 ), but this reduction did not extend to 24 h. In most cases, the phage and extract combinations did not significantly reduce bacterial content compared to phages alone. Additionally, there was little impact on the ability of the phages to reproduce within their bacterial hosts. To our knowledge, this study represents the first of its kind, in which antimicrobial plant extracts have been combined with virulent phages and has highlighted the necessity for plant extracts to be functionally characterized prior to the design of combinatorial therapies.

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“…EOs are also called volatile oils or ethereal oils, as they have a high degree of evaporation when exposed to air at room temperature; this feature confers the strong odor to plants, both to attract pollinators and to repel insects and herbivores [14]. …”

Section: Introductionmentioning

confidence: 99%

Essential Oil of Cymbopogon nardus (L.) Rendle: A Strategy to Combat Fungal Infections Caused by Candida Species

Toledo

Ramos

Spósito

et al. 2016

IJMS

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Background: The incidence of fungal infections, especially those caused by Candida yeasts, has increased over the last two decades. However, the indicated therapy for fungal control has limitations. Hence, medicinal plants have emerged as an alternative in the search for new antifungal agents as they present compounds, such as essential oils, with important biological effects. Published data demonstrate important pharmacological properties of the essential oil of Cymbopogon nardus (L.) Rendle; these include anti-tumor, anti-nociceptive, and antibacterial activities, and so an investigation of this compound against pathogenic fungi is interesting. Objective: The aim of this study was to evaluate the chemical composition and biological potential of essential oil (EO) obtained from the leaves of C. nardus focusing on its antifungal profile against Candida species. Methods: The EO was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Testing of the antifungal potential against standard and clinical strains was performed by determining the minimal inhibitory concentration (MIC), time-kill, inhibition of Candida albicans hyphae growth, and inhibition of mature biofilms. Additionally, the cytotoxicity was investigated by the IC50 against HepG-2 (hepatic) and MRC-5 (fibroblast) cell lines. Results: According to the chemical analysis, the main compounds of the EO were the oxygen-containing monoterpenes: citronellal, geranial, geraniol, citronellol, and neral. The results showed important antifungal potential for all strains tested with MIC values ranging from 250 to 1000 μg/mL, except for two clinical isolates of C. tropicalis (MIC > 1000 μg/mL). The time-kill assay showed that the EO inhibited the growth of the yeast and inhibited hyphal formation of C. albicans strains at concentrations ranging from 15.8 to 1000 μg/mL. Inhibition of mature biofilms of strains of C. albicans, C. krusei and C. parapsilosis occurred at a concentration of 10× MIC. The values of the IC50 for the EO were 96.6 μg/mL (HepG-2) and 33.1 μg/mL (MRC-5). Conclusion: As a major virulence mechanism is attributed to these types of infections, the EO is a promising compound to inhibit Candida species, especially considering its action against biofilm.

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Antimicrobial activity of natural products against Helicobacter pylori: a review

Cited by 38 publications

References 51 publications

Volatile Profiling, Insecticidal, Antibacterial and Antiproliferative Properties of the Essential Oils of Bursera glabrifolia Leaves

Volatile Profiling, Insecticidal, Antibacterial and Antiproliferative Properties of the Essential Oils of Bursera glabrifolia Leaves

In vitroactivity of a combination of bacteriophages and antimicrobial plant extracts

Essential Oil of Cymbopogon nardus (L.) Rendle: A Strategy to Combat Fungal Infections Caused by Candida Species

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