Antimicrobial activity of new porphyrins of synthetic and natural origin

Gyulkhandanyan, Grigor V.; Ghazaryan, Robert K.; Paronyan, Marina H.; Ulikhanyan, Ghukas I.; Gyulkhandanyan, Aram G.; Sahakyan, Lilit

doi:10.1117/12.908634

Cited by 5 publications

(6 citation statements)

References 26 publications

(36 reference statements)

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“…Meanwhile, cationic water‐soluble synthetic metalloporphyrins, especially Zn‐TBut 4 PyP, was found to be extremely effective in PDI. In vivo conditions on mice established that Ag‐TBut 4 PyP had the best therapeutic activity against various strains of S. aureus , and was significantly more efficient than known drug ’Chlorophyllipt’ (2.5–3 times) and improved the survival rate of animals up to 50–60% …”

Section: Types Of Porphyrin Based Compounds For Anti‐microbial Pdi Trmentioning

confidence: 99%

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A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

Gan

Gao

et al. 2016

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The emergence of multidrug resistant bacterium threatens to unravel global healthcare systems, built up over centuries of medical research and development. Current antibiotics have little resistance against this onslaught as bacterium strains can quickly evolve effective defense mechanisms. Fortunately, alternative therapies exist and, at the forefront of research lays the photodynamic inhibition approach mediated by porphyrin based photosensitizers. This review will focus on the development of various porphyrins compounds and their incorporation as small molecules, into polymers, fibers and thin films as practical therapeutic agents, utilizing photodynamic therapy to inhibit a wide spectrum of bacterium. The use of photodynamic therapy of these porphyrin molecules are discussed and evaluated according to their electronic and bulk material effect on different bacterium strains. This review also provides an insight into the general direction and challenges facing porphyrins and derivatives as full-fledged therapeutic agents and what needs to be further done in order to be bestowed their rightful and equal status in modern medicine, similar to the very first antibiotic; penicillin itself. It is hoped that, with this perspective, new paradigms and strategies in the application of porphyrins and derivatives will progressively flourish and lead to advances against disease.

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Section: Types Of Porphyrin Based Compounds For Anti‐microbial Pdi Trmentioning

confidence: 99%

“…Structures of cationic porphyrins TBut 4 PyP, TOEt 4 PyP, TAll 4 PyP, TMetAll 4 PyP and their corresponding metalloporphyrins …”

Section: Types Of Porphyrin Based Compounds For Anti‐microbial Pdi Trmentioning

confidence: 99%

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

Gan

Gao

et al. 2016

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125

106

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“…In addition to the important effect of Hmox1 activity and its products in controlling inflammatory diseases and bacterial infections, porphyrins alone have also been studied as possible treatments for bacterial infections [ 54 , 55 ]. Although metalloporphyrins, such as CoPP and SnPP, have a very similar structure and can mimic some effects of heme, these have many differences in their antimicrobial effect.…”

Section: Discussionmentioning

confidence: 99%

Limited Heme Oxygenase Contribution to Modulating the Severity of Salmonella enterica serovar Typhimurium Infection

et al. 2022

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An important virulence trait of Salmonella enterica serovar Typhimurium (S. Typhimurium) is the ability to avoid the host immune response, generating systemic and persistent infections. Host cells play a crucial role in bacterial clearance by expressing the enzyme heme oxygenase 1 (Hmox1), which catalyzes the degradation of heme groups into Fe2+, biliverdin, and carbon monoxide (CO). The role of Hmox1 activity during S. Typhimurium infection is not clear and previous studies have shown contradictory results. We evaluated the effect of pharmacologic modulation of Hmox1 in a mouse model of acute and persistent S. Typhimurium infection by administering the Hmox1 activity inductor cobalt protoporphyrin-IX (CoPP) or inhibitor tin protoporphyrin-IX (SnPP) before infection. To evaluate the molecular mechanism involved, we measured the colocalization of S. Typhimurium and autophagosome and lysosomal markers in macrophages. Administering CoPP reduced the bacterial burden in organs of mice 5 days post-infection, while SnPP-treated mice showed bacterial loads similar to vehicle-treated mice. Furthermore, CoPP reduced bacterial loads when administered after infection in macrophages in vitro and in a persistent infection model of S. Typhimurium in vivo, while tin protoporphyrin-IX (SnPP) treatment resulted in a bacterial burden similar to vehicle-treated controls. However, we did not observe significant differences in co-localization of green fluorescent protein (GFP)-labeled S. Typhimurium with the autophagic vesicles marker microtubule-associated protein 1A/1B-light chain 3 (LC3) and the lysosomal marker lysosomal-associated membrane protein 1 (LAMP-1) in macrophages treated with CoPP. Our results suggest that CoPP can enhance antimicrobial activity in response to Salmonella infection, reducing bacterial dissemination and persistence in mice, in a CO and autophagy- independent manner.

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“…Toxicity and Photo-toxicity properties of the laboratory synthesized Porphyrin derivatives were evaluated against the four test organisms by agar well diffusion method of Gyulkhandanyan et al [29] with modifications. Pure colonies from the overnight culture of each of the four test isolates were dislodged in sterile normal saline and vortex mixed.…”

Section: Antibacterial Activities Of Synthesized Porphyrin Derivativesmentioning

confidence: 99%

Antibacterial Photodynamic Therapeutic Studies of Metallated Porphyrin Against Chronic Wound Colonising Bacterial Isolates

Daramola¹,

Olajide²,

Torimiro³

et al. 2021

JCSN

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Wound infections have become life threatening as a result of treatment failures caused by multi-drug resistant pathogens. The search for newer compounds potent against antibiotic resistant bacteria associated with wounds is crucial. Hence this study investigated the application of antibacterial photodynamic therapy using meso tetra-(4-phenyl) porphyrin (TPP), metallated with zinc, tin and silver (ZnTPP, SnTPP and AgTPP), meso tetra-(4-sulphonatephenyl) porphyrin (TPPS) and the corresponding metallo meso tetra-(4-sulphonatephenyl) porphyrin (MTPPS) as photosensitizers. The in-vitro toxicity and photo-toxicity properties on four chronic wound colonizing multi-drug resistant bacterial strains: Staphylococcus aureus, Klebsiella sp., Proteus sp., and Escherichia coli were assessed using agar well diffusion method. Photo-toxicity of the compounds was investigated using 100 Watt tungsten lamp. Inhibitory activity of porphyrins tested against these bacterial strains showed Staphylococcus aureus to have both lowest (11±0.0 mm) and highest (33±1.1 mm) susceptibility to SnTPPS and ZnTPPS respectively. The sequence of data also showed appreciable improvement in the antimicrobial activities of five metalloporphyrins (SnTPP, AgTPP, ZnTPPS, SnTPPS and AgTPPS) exposed to light rays than when tested against bacterial strains in dark condition. ZnTPPS exhibited the best activity with improved photo-toxic activities against all bacterial strains (Staphylococcus aureus 33±1.1 mm, Klebsiella sp. 32±0.7 mm, Proteus sp. 28±0.7 mm and Escherichia coli 30±1.4 mm) examined in this study.

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Antimicrobial activity of new porphyrins of synthetic and natural origin

Cited by 5 publications

References 26 publications

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

Limited Heme Oxygenase Contribution to Modulating the Severity of Salmonella enterica serovar Typhimurium Infection

Antibacterial Photodynamic Therapeutic Studies of Metallated Porphyrin Against Chronic Wound Colonising Bacterial Isolates

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