Antimicrobial activity of organotin(IV) complexes with the ligand benzil bis(benzoylhydrazone) and 4,4′-bipyridyl as coligand

Diorganotin(IV) complexes with 2-furancarboxylic acid hydrazone derivative of benzoylacetone: Synthesis, X-ray structure, antibacterial activity, DNA cleavage and molecular docking

“…Facile keto-enol tautomerization and the availability of several potential donor sites in these ligands allows and encourages chemists to construct complexes with large structural varieties [15]. Along this line, organotin(IV) complexes of hydrazones have received considerable attention for both structural and biological importance: many of these compounds may interact with biological systems in different ways as bactericides, fungicides, acaricides and industrial biocides [16][17][18][19][20][21]. Recently these compounds have been used in new contexts as in cancer chemotherapy [22,23].…”

Synthesis, antimicrobial activity and molecular docking of di‐ and triorganotin (IV) complexes with thiosemicarbazide derivatives

“…Hydrazones and thiosemicarbazones have received much attention over the last decades due to their fascinating structural versatility together with their outstanding therapeutic activities, such as antitumor, antiviral, antiprotozoal, antibacterial or antifungal agents . As a continuation of our studies on the synthesis and antimicrobial activity of organotin (IV) complexes with thiosemicarbazone/hydrazone ligands, we have synthesized two ligands, one mixed thiosemicarbazone/hydrazone ligand, L 1 H 2 , and one mono (thiosemicarbazone), HATs, and their complexes with SnR 2 Cl 2 and SnR 3 Cl (R = Me, Bu, Ph), respectively. In a previous work we have found that introduction of a lipophilic pendant group in the terminal amine of the thiosemicarbazone do not increase the antimicrobial activity of the complexes, so we decided to introduce a NH 2 group, which is less lipophilic but has less steric hindrance to evaluate if the ligand size could have any influence in the antimicrobial properties.…”

Synthesis, characterization, crystal structures, QSAR study and antibacterial activities of organotin bisphosphoramidates

“…In this context, the potent therapeutic properties of tin complexes are well known [1][2][3]. The chemistry of organotins has received considerable attention during the last few decades owing to their industrial (catalysts in PVC and foam production), agricultural (fungicides and acaricides, wood preservatives) and medicinal applications (antibacterial and anticancer agents) [4][5][6][7].…”

“…Quantitative structureactivity relationship (QSAR) equations enabled to create the correlation between the electronic and structural parameters of OTPA derivatives and the antibacterial activity [9-M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 7 8H, Ph). 13 C NMR (d6-DMSO, ppm); δ= 29.1 (m, β-CH 2 ), 38.0 (m, α-CH 2 ), 128.9 (d, 3 The complexes were prepared by using the similar procedure: Methanol-chloroform solutions of 2 eq. organotin chloride (SnMe 2 Cl 2 , SnPh 3 Cl, SnPh 2 Cl 2 or SnPhCl 3 ) with 1 eq.…”

“…Ph 2 P(O)N(C 4 H 8 )NP(O)Ph 2 .SnPh 2 Cl 2 ] n (C b5 ) Ph 2 P(O)O-C 6 H 4 -OP(O)Ph 2 ][SnPh3 Cl] 2 (C a6 )[17] Mp: 171-173 °C 1. H NMR (CDCl 3 , ppm): δ = 7.04 (s, 4H, C 6 H 4 ), 7.41-7.57 (m, 30H, Ph-P + Ph-Sn), 7.66-7.70 (m, 12H, 3 J( 119/117 Sn, 1 H) = 60 Hz, o-Ph 3 Sn), 7.79-7.86 (m, 8H, Ph-P).…”