Antimicrobial activity of organotin(IV) compounds: a review

Baul, Tushar S. Basu

doi:10.1002/aoc.1378

Cited by 157 publications

(46 citation statements)

References 61 publications

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“…Further samples of stannane of pyridoxal 5-phosphatewith different concentrations (0.001 g/100 ml, 0.0005 g/100 ml, 0.00025 g/100 ml and 0.000125 g/100 ml in ethanol) were introduced into different wells. The plates were then incubated immediately at 37 °Cfor 24 h [8,6]. Inhibition zone was measured in mm,…”

Section: In Vitro Antibacterial Testmentioning

confidence: 99%

“…The antimicrobial activity of the synthesised compounds may be due to the presence of a functional pharmacophore, which maximises the lipophilic character of the molecules and eases its movement across the cell membrane of the microorganism [17]. From the observation, it has been assumed that the generation of a specific enzyme which needs free sulfhydryl groups (-SH) for their cellular activity was especially liable to deactivation by ions of the complex [18]. Due to which the organisms were less able to metabolise nutrient and, consequently their growth hindered.…”

Section: H Nmrmentioning

confidence: 99%

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In Vitro and in Silico Antimicrobial Study of Stannane of Pyridoxal 5-Phosphate

Aniyery

Gupta

Singh

et al. 2017

Int J Pharm Pharm Sci

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Objective: The main objective of this research work is to synthesize a novel stannane of pyridoxal 5-phosphateand to study its antibacterial property. Methods:Conventional method was used to synthesize the stannane of pyridoxal 5-phosphateand its characterization was carried using UV-visible and 1Results: It was observed that the stannane of pyridoxal 5-phosphateinhibited bacterial growth of Staphylococcus aureus (gram positive) and Escherichia coli 1610 (gram negative) in vitro antibacterial study. The complex has shown good docking results on almost all the receptors, with interaction supporting the fitting of the drug to the target molecules. The novel complex has shown good antibacterial activity (theoretically) in insilico studies. It was found to having a good potency to efficiently inhibit the microbes Burkholderia pseudomallei, Human cytomegalovirus, Yersinia enterocolitica and Escherichia coli, based on the interaction profile. The synthesized stannane was found to be effective in halting the undesirable effects of selected PDB files.H NMR. The antibacterial study was carried against, Staphylococcus aureus (gram positive) and Escherichia coli 1610(gram negative) using well diffusion method. In silico antimicrobial was carried out using computational software iGemDock v2.1 tool.(Graphical Drug Design system for Docking, Screening, and Post-analysis), computational docking was carried out using different PDB (Protein Data Bank) files (2I42, 3EOO, 3D2U and 3D2Y). The structure was optimized prior docking using Gaussian software, and the method followed was Energy (Ground state) Hartree-Fork. Conclusion:On the basis of the above findings in the present research work, the novel complex was found to be a good antimicrobial agent and our future studies will aim design of novel selective and potent inhibitors. Further in vitro studies of this compound against these bacteria will lead to a new pathway to a novel antibacterial drug discovery.

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Section: In Vitro Antibacterial Testmentioning

confidence: 99%

Section: H Nmrmentioning

confidence: 99%

In Vitro and in Silico Antimicrobial Study of Stannane of Pyridoxal 5-Phosphate

Aniyery

Gupta

Singh

et al. 2017

Int J Pharm Pharm Sci

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“…[(PhC(CH 3 ) 2 CH 2 ) 3 Sn] 2 O 等. 大量的研究结果表明, 三烃基锡化合物的生物活性与锡原子上烃基的种类有关 [1][2][3] ; 并且对于分子中同时含有环己基、丁基或苯基的混合三烃基锡化合物, 则可能既有杀菌活性, 又有杀螨活性 [4,5] .…”

Section: 许多三烃基锡化合物由于具有一定的生物活性已被广泛作为杀螨剂、杀虫剂和杀菌剂应用于农业生产中如杀菌剂薯瘟锡(三unclassified

“…大量的研究结果表明, 三烃基锡化合物的生物活性与锡原子上烃基的种类有关 [1][2][3] ; 并且对于分子中同时含有环己基、丁基或苯基的混合三烃基锡化合物, 则可能既有杀菌活性, 又有杀螨活性 [4,5] . 杨志强等在对 Bu n Cy 3-n SnX 类化合物研究中, 发现其杀虫和杀菌随着 n 的变化而变化, 当 n＝2 时, 这类化合物同时兼有较高的杀菌和杀螨活性 [6] .…”

Section: 许多三烃基锡化合物由于具有一定的生物活性已被广泛作为杀螨剂、杀虫剂和杀菌剂应用于农业生产中如杀菌剂薯瘟锡(三unclassified

Syntheses and Characterization of Cyclohexyl(phenyl)-[(trimethylsilyl)methyl]stannyl Aromatic Carboxylates

龚根飞¹,

宋冉²,

邹引波³

et al. 2013

Chin. J. Org. Chem.

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“…[1] 、抗癌活性 [2,3] 、细胞毒性和抗氧化活性 [4] 等, 是近年来研究较为活跃的一类 [13,14] . 由于低分子量有机锡毒性较大, 能严重损害动由含有活泼氢的配体制备二烃基锡配合物, 常用的方法有: (a)用二烃基锡氧化物或氢氧化物与配体进行脱水反应 [20] ; (b)二烃基锡卤化物与配体在适当的缚酸剂如三乙胺、乙醇钠等存在下反应 [21] ; (c)先将配体与碱反应成盐后再与二烃基锡卤化物反应 [22] ; (d)配体与有机锡氢化物反应 [23] .…”

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