Antimicrobial activity of poly(acrylic acid) block copolymers

Gratzl, Günther; Paulik, Christian; Hild, Sabine; Guggenbichler, J. P.; Lackner, Maximilian

doi:10.1016/j.msec.2014.01.050

Cited by 65 publications

(49 citation statements)

References 74 publications

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“…Figure 6 shows the comparison of FTIR-ATR spectra obtained for PU, PU-COOH max and PU-REDV surfaces. A characteristic stretching vibration band at 3700-3400cm -1 that relates to NH 2 , -OH and -C=O groups is shown [18]. The signal was more intense for PU-REDV than for other materials, which indicates the presence of peptide containing amine groups.…”

Section: Wettability Measurementmentioning

confidence: 89%

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Polyurethane modification with acrylic acid by Ce(IV)-initiated graft polymerization

et al. 2016

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This paper presents a method for polyurethane surface functionalization for tissue engineering applications. Functionalization has been carried out by grafting acrylic acid to the polyurethane surface with the use of radical polymerization with a Ce 4+ initiator. Contrary to other papers suggesting that the presence of hydroxyl groups are essential for successful grafting via ceric ions, we propose a method with the omission of the surface hydroxylation step. The influence of reaction conditions: reaction time, reaction temperature and monomer concentration on carboxyl groups surface density has been analyzed and described. The quantity of carboxyl groups on the surface was determined with the use of the TBO method. Materials grafted with acrylic acid have been subjected to conjugation with a peptide using sulfoNHS/ EDC chemistry. Successful incorporation of the peptide has been confirmed by an ELISA assay. Additionally, for better characterization, after each step of modification materials were subjected to SEM, FTIR-ATR, XPS and contact angle measurement analysis.

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Section: Wettability Measurementmentioning

confidence: 89%

“…Furthermore, polymerized AA -poly(acrylic acid) (PAA) -not only provides COOH functional groups, but according to a recent study, also exhibits antimicrobial properties. It was demonstrated that PAA containing diblock copolymers prevents biofilm formation [18]. This is certainly a desired feature for a biomaterial.…”

Section: +mentioning

confidence: 99%

Polyurethane modification with acrylic acid by Ce(IV)-initiated graft polymerization

et al. 2016

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“…It was reported that the length of pluronic block in PAA block copolymer determined the mucoadhesive properties, which increased with increase in the length of pluronic block [7]. PAA-polystyrene and PAA-poly(methyl methacrylate) block copolymers was found to prevent the biofilm formation [8]. Thermal and pH responsive coreshell-corona micelles were prepared using poly(t-butyl acrylate-co-acrylic acid)-b-poly(N-isopropylacrylamide) and investigated for gene and drug delivery applications [9].…”

Section: Introductionmentioning

confidence: 99%

“…[5]. Large number of comonomers were used to modify the physical, chemical and thermal properties of copolymers of poly(acrylic acid) (PAA) [5][6][7][8][9][10][11][12][13][14][15]. Depending upon the application requirements, the selection of comonomers varied from hydrophilic to hydrophobic.…”

Section: Introductionmentioning

confidence: 99%

Effect of butyl lactate methacrylate content on the properties of acrylic acid copolymers

Purushothaman¹,

Krishnan

Nayak

2016

Polym. Sci. Ser. A

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In the present work, the effect of butyl lactate methacrylate (BLM) content on the properties of acrylic acid (AA) copolymers was investigated. The BLM monomer was synthesized by reacting butyl lactate with methacrylic acid through azeotropic distillation method, which was confirmed by Mass spectrometric technique. Copolymers were synthesized by free-radical solution polymerization technique to obtain poly(BLM-co-AA). BLM monomer and copolymers were characterized by Fourier transform infrared (FTIR), 1 H-nuclear magnetic resonance ( 1 H-NMR) and proton decoupled 13 C-NMR spectroscopic techniques. The Finemann-Ross method was used to determine the reactivity ratio of AA and BLM and the values were found to be 0.79 and 0.39, respectively. The wide angle X-ray scattering (WAXS) studies exhibited that the increase in BLM content in copolymers, shifted the amorphous halo from 21.34° to 15.39° and also increased the average molecular interchain spacing (〈R〉) from 5.20 to 7.18 Å, which was calculated from 2θ values of amorphous halo of copolymers. Moisture absorption of polymers followed Fickian absorption. Depending upon the copolymer composition, relative humidity and time, the moisture absorption of copolymers can be tuned to a wide range from 11 to 35% (wt/wt). Glass transition temperature of copolymers decreased from 106 to 72.1°C with increase in BLM content. Copolymers were thermally stable up to 150°C and thereafter exhibited three-step thermal degradation in nitrogen atmosphere. Thermal stability of copolymers can be explained on the basis of 〈R〉 value.

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“…These polymers are prepared either by (co-)polymerization of functionalized monomers or by post-polymerization functionalization [12]. Though, the antimicrobial properties are derived from a variety of functionalities such as biguanides [13,14], benzoate esters and benzaldehydes [15], or poly(acrylic acid) [16], the most common active moieties are based on a combination of quaternary ammonium, pyridinium, or phosphonium groups and hydrophobic functionalities [17][18][19]. The proposed and commonly accepted mechanism for these types of polymers…”

Section: Introductionmentioning

confidence: 99%

Novel Antibacterial Polyglycidols: Relationship between Structure and Properties

et al. 2018

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Antimicrobial polymers are an attractive alternative to low molecular weight biocides, because they are non-volatile, chemically stable, and can be used as non-releasing additives. Polymers with pendant quaternary ammonium groups and hydrophobic chains exhibit antimicrobial properties due to the electrostatic interaction between polymer and cell wall, and the membrane disruptive capabilities of the hydrophobic moiety. Herein, the synthesis of cationic-hydrophobic polyglycidols with varying structures by post-polymerization modification is presented. The antimicrobial properties of the prepared polyglycidols against E. coli and S. aureus are examined. Polyglycidol with statistically distributed cationic and hydrophobic groups (cationic-hydrophobic balance of 1:1) is compared to (i) polyglycidol with a hydrophilic modification at the cationic functionality; (ii) polyglycidol with both-cationic and hydrophobic groups-at every repeating unit; and (iii) polyglycidol with a cationic-hydrophobic balance of 1:2. A relationship between structure and properties is presented.

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Antimicrobial activity of poly(acrylic acid) block copolymers

Cited by 65 publications

References 74 publications

Polyurethane modification with acrylic acid by Ce(IV)-initiated graft polymerization

Polyurethane modification with acrylic acid by Ce(IV)-initiated graft polymerization

Effect of butyl lactate methacrylate content on the properties of acrylic acid copolymers

Novel Antibacterial Polyglycidols: Relationship between Structure and Properties

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