Antimicrobial Activity of Polyhexamethylene Guanidine Derivatives Introduced into Polycaprolactone

Brzezinska, Maria Swiontek; Walczak, Maciej; Jankiewicz, Urszula; Pejchalová, Marcela

doi:10.1007/s10924-017-0974-9

Cited by 35 publications

(14 citation statements)

References 27 publications

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“…Poorly water-soluble PHMG salts such as PHMG stearate, PHMG sulfanilate, or PHMG dodecylbenzenesulfonate (PHMG-DBS) have been reported as efficient antimicrobial additives for polycaprolactone [34], polylactide [35], polyamides [36,37] and silicones [38]. PHMG-DBS was found to have sufficient thermal stability to be melt processed with PA-11 and PA-12 resins by conventional methods [36,37].…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Moshynets

Bardeau

Tarasyuk

et al. 2019

IJMS

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The choice of efficient antimicrobial additives for polyamide resins is very difficult because of their high processing temperatures of up to 300 °C. In this study, a new, thermally stable polymeric biocide, polyhexamethylene guanidine 2-naphtalenesulfonate (PHMG-NS), was synthesised. According to thermogravimetric analysis, PHMG-NS has a thermal degradation point of 357 °C, confirming its potential use in joint melt processing with polyamide resins. Polyamide 11 (PA-11) films containing 5, 7 and 10 wt% of PHMG-NS were prepared by compression molding and subsequently characterised by FTIR spectroscopy. The surface properties were evaluated both by contact angle, and contactless induction. The incorporation of 10 wt% of PHMG-NS into PA-11 films was found to increase the positive surface charge density by almost two orders of magnitude. PA-11/PHMG-NS composites were found to have a thermal decomposition point at about 400 °C. Mechanical testing showed no change of the tensile strength of polyamide films containing PHMG-NS up to 7 wt%. Antibiofilm activity against the opportunistic bacteria Staphylococcus aureus and Escherichia coli was demonstrated for films containing 7 or 10 wt% of PHMG-NS, through a local biocide effect possibly based on an influence on the bacterial eDNA. The biocide hardly leached from the PA-11 matrix into water, at a rate of less than 1% from its total content for 21 days.

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Section: Introductionmentioning

confidence: 99%

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Moshynets

Bardeau

Tarasyuk

et al. 2019

IJMS

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“…There are large hydrophilic lipopolysaccharide molecules on the outside of the membrane, which can block easy access of these polymers to phospholipids and thence to the cell interior [24]. Brzezińska et al [14], who indicate that polycaprolactone containing PHMG salt of sulfanilic acid inhibited biofilm formation, stated that PHMG could affect different metabolic pathways and cell elements.…”

Section: Resultsmentioning

confidence: 99%

“…This destabilises the osmotic equilibrium and destructs the cytoplasmic membrane. As a consequence, PHMG causes a loss of membrane function in bacteria or fungi [12][13][14]. The extent of membrane disruption is shown to increase with an increase in the polymer length.…”

mentioning

confidence: 99%

Antimicrobial Activity of Monolayer and Multilayer Films Containing Polyhexamethylene Guanidine Sulphanilate

Gendaszewska¹,

Szuster²,

Wyrębska³

et al. 2018

Fibres and Textiles in Eastern Europe

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The aim of this study was to determine the antimicrobial properties of multilayer films containing a PHMG sulphanilate (polyhexamethylene guanidine sulphanilate). Three types of films were selected: monolayer and three-layer films (both containing biocide) and market foil. The antibacterial activity of polyethylene film with PHMG sulphanilate was verified based on the guidelines of ISO 22196: 2007 (E): Plastics – Measurement of antibacterial activity on plastic surfaces. The antimicrobial efficacy of the monolayer film against Escherichia coli and Staphylococcus aureus was very good, equalling 6.25 log (100%) and 6.02 log (100%), respectively. It means that a total reduction in bacteria on the surface tested was achieved. The antimicrobial efficacy of the three-layer film against Escherichia coli was satisfactory and equaled 1.32 log (95.2%). The antimicrobial efficacy of this film against Staphylococcus aureus was very good and equaled 6.02 log (100%). The antifungal activity of polyethylene film with PHMG sulphanilate was verified based on the guidelines of ASTM G21 – 96: Standard practice for determining the resistance of synthetic polymeric materials to fungi. The fungal growth of Aspergillus niger, Chaetomium globosum and Trichoderma viride on the monolayer and three layer films was also inhibited, which means that the biocide in the films also exhibits antifungal activities. For the market foil, poor antibacterial efficacy against the bacteria and no antifungal activity against the fungi tested was observed.

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“…Our research shows that PHMG significantly inhibited only the activity of C. albicans hydrolases. Walczak et al [13] and Swiontek Brzezinska et al [34,35] studied the effect of PHMG derivatives introduced into the PLA, PHB and PCL on the activity of the bacterial hydrolases. Their research shows that the tested composites do not have a significant impact on reducing the activity of hydrolases.…”

Section: Effect Of Phmg Derivatives On Fungal Hydrolase Activitymentioning

confidence: 99%

Antifungal Activity of Polyhexamethyleneguanidine Derivatives Introduced into Biodegradable Polymers

et al. 2019

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Experiments were conducted to investigate the antifungal activities of polyhexamethyleneguanidine (PHMG) derivatives introduced into polylactide (PLA), polyhydroxybutyrate (PHB) and polycaprolactone (PCL) against Aspergillus niger, Penicillium chrysogenum and Candida albicans. All of the PHMG derivatives inhibited the germination of A. niger and P. chrysogenum. All of the derivatives exerted a much stronger inhibitory effect on the cells of C. albicans. PHMG granular polyethylene wax (at the concentration of 1.0%) has a fungicidal effect. The reduction in the number of yeast cells capable of growing on the surface composites PLA, PHB and PCL with PHMG granular polyethylene wax for 24 h was R > 2. PHMG derivatives introduced into PLA decreased hydrolases activity in A. niger and P. chrysogenum. All of the PHMG derivatives introduced into all investigated polymers inhibited the hydrolases activity in C. albicans proportionately to concentration. PHMG granular polyethylene wax at a concentration of 1.0% most strongly inhibited hydrolases activity in yeast. The composites produced from PLA, PHB, PCL and this PHMG derivatives can be used in many areas to reduce the growth of yeast. The studied composites can potentially be used for the production of biomedical or packaging materials.

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Antimicrobial Activity of Polyhexamethylene Guanidine Derivatives Introduced into Polycaprolactone

Abstract: showed the highest inhibitory effect on the activity of both enzymes. W-PCL and A-PCL composites (at concentration of 0.6%) have optimal combination of antibiofilm activity and biodegradability.

Cited by 35 publications

References 27 publications

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Antimicrobial Activity of Monolayer and Multilayer Films Containing Polyhexamethylene Guanidine Sulphanilate

Antifungal Activity of Polyhexamethyleneguanidine Derivatives Introduced into Biodegradable Polymers

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