Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants

Othman, Leen; Sleiman, Ahmad; Abdel-Massih, Roula M.

doi:10.3389/fmicb.2019.00911

Cited by 466 publications

(348 citation statements)

References 88 publications

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“…It was observed that strains of S. cerevisiae had no antimicrobial activity against Staphylococcus spp. [29]. and weak inhibitions (2 mm) against E. coli; this is in collaboration with Venkatesan et al [30] which showed that S. cerevisiae had no activity against Staphylococcus aureus and very poor inhibition against E. coli.…”

Section: Antimicrobial Activity Of Yeast Isolates Against Selected Pasupporting

confidence: 70%

Microbiological and Probiotic Assessment of Yeast Isolated from Wholegrain Millet Sourdoughs

Adisa¹,

Ifesan²,

Enujiugha³

et al. 2020

JAMB

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Background: The term probiotics have been described as live microorganisms associated with fermented foods that confer health benefit to the host. For a long time, researches into the world of probiotics have extensively and predominantly centred upon species of lactic acid bacteria and until recently Saccharomyces cerevisiae, as the only well-defined and proven probiotic yeast strain. The purpose of this study was to isolate and characterise the yeast species associated with the fermentation of wholegrain millet sourdoughs and investigate in vitro the possible probiotic potential of the isolates. Methodology: Wholegrain millet sourdoughs were prepared by spontaneous fermentation of the flours with tap water in the ratio 1:1 (w/v) for 48 h at 28 ± 2ºC through backslopping. A total of twenty five yeasts were identified based on their cultural, morphological and biochemical characteristics. The selected isolates were characterized to species level using API 20 C AUX test identification kit. Probiotic properties examined included bile salt and acid tolerance under conditions simulating the human gastrointestinal tract (GIT) and positive antagonistic activity against selected pathogens following well established procedures. Results: The selected isolates investigated were characterized to belong to species of Saccharomyces and Kluveromyces. All of the isolates were discovered to exhibit sufficient survival under acidic pH of 2.0 with values ranging from 1.0log cfu ml-1 to 7.8log cfu ml-1 and showed high resistance to bile salt with values ranging from 63-99%. They also exhibited good antimicrobial activity against enteric pathogens of E. coli, Salmonella typhimurium, Staphylococcus aureus, Klebsiella pneumonia, Streptococcus pyogenes, Proteus vulgaris and Pseudomonas sp. Conclusion: Millet sourdoughs can serve as an affordable nutritionally healthy substrate for delivery of probiotics to the gastro-intestinal tract, thereby proffering basic health functionality. This study allowed to isolate and to identify yeast species present in millet sourdoughs with technological potential for sourdough applications.

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Section: Antimicrobial Activity Of Yeast Isolates Against Selected Pasupporting

confidence: 70%

Microbiological and Probiotic Assessment of Yeast Isolated from Wholegrain Millet Sourdoughs

Adisa¹,

Ifesan²,

Enujiugha³

et al. 2020

JAMB

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“…Numerous studies have considered the antimicrobial screening of traditional plant extracts. The studies of medicinal plants from diverse topographical areas include: Armenia [65], Iran [66], Mexico [67], Saudi Arabia [68], Libya [26], Ethiopia [64], India [63], Poland [69], Cameroon [70], Nigeria [71], and other Middle Eastern countries [72]. Based on the available information, the traditional plant extracts showed antimicrobial activity against a huge number of pathogenic bacteria, fungi, viruses, algae, protozoan, and Trypanosoma [26,63,64,66].…”

Section: Phytocomponent Fractions and Antimicrobial Methodsmentioning

confidence: 99%

Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

Mickymaray

2019

Antibiotics

118

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Traditional medicinal plants have been cultivated to treat various human illnesses and avert numerous infectious diseases. They display an extensive range of beneﬁcial pharmacological and health effects for humans. These plants generally synthesize a diverse range of bioactive compounds which have been established to be potent antimicrobial agents against a wide range of pathogenic organisms. Various research studies have demonstrated the antimicrobial activity of traditional plants scientifically or experimentally measured with reports on pathogenic microorganisms resistant to antimicrobials. The antimicrobial activity of medicinal plants or their bioactive compounds arising from several functional activities may be capable of inhibiting virulence factors as well as targeting microbial cells. Some bioactive compounds derived from traditional plants manifest the ability to reverse antibiotic resistance and improve synergetic action with current antibiotic agents. Therefore, the advancement of bioactive-based pharmacological agents can be an auspicious method for treating antibiotic-resistant infections. This review considers the functional and molecular roles of medicinal plants and their bioactive compounds, focusing typically on their antimicrobial activities against clinically important pathogens.

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“…The majority of these studies have focused on food-borne pathogens, but reveal the potential for natural and sustainable sources of antimicrobial compounds. While in vitro restriction of many bacterial, fungal and viral pathogens has been evidenced (reviewed in [1,30,31]), polyphenols are also capable of specific inhibition of pathogen virulence. A striking example of this is the ability of tannic acid and n -propyl gallate to protect mice from Helicobacter pylori -mediated disease [32].…”

Section: Discussionmentioning

confidence: 99%

High-polyphenol extracts fromSorghum bicolorattenuate replication ofLegionella pneumophilawithin RAW 264.7 macrophages

Gilchrist

Smolensky

Cox

et al. 2019

Preprint

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Polyphenols derived from a variety of plants have demonstrated antimicrobial activity against diverse microbial pathogens. Legionella pneumophila is an intracellular bacterial pathogen that opportunistically causes a severe inflammatory pneumonia in humans, called Legionnaires’ Disease, via replication within macrophages. Previous studies demonstrated that tea polyphenols attenuate L. pneumophila intracellular replication within mouse macrophages via amplification of tumor necrosis factor (TNF) production. Sorghum bicolor is a sustainable and resilient cereal crop that thrives in arid environments and is well suited to continued production in warming climates. Polyphenols derived from sorghum have anticancer and antioxidant properties, but their antimicrobial activity has not been evaluated. Here, we investigated the impact of sorghum polyphenols on L. pneumophila intracellular replication within RAW 264.7 mouse macrophages. We discovered that sorghum high-polyphenol extract (HPE) treatment attenuates L. pneumophila intracellular replication in a dose-dependent manner. Sorghum HPE did not impair bacterial replication in vitro or impact macrophage viability. Moreover, in contrast to tea polyphenols, HPE treatment impaired TNF secretion from infected macrophages. Thus, polyphenols derived from sorghum enhance macrophage restriction of L. pneumophila by a novel mechanism. This work provides a foundation for the use of sorghum as an antimicrobial agent.

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Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants

Cited by 466 publications

References 88 publications

Microbiological and Probiotic Assessment of Yeast Isolated from Wholegrain Millet Sourdoughs

Microbiological and Probiotic Assessment of Yeast Isolated from Wholegrain Millet Sourdoughs

Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

High-polyphenol extracts fromSorghum bicolorattenuate replication ofLegionella pneumophilawithin RAW 264.7 macrophages

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