Antimicrobial activity of Pycnogenol<sup>®</sup>

Torras, Maria Angeles Calvo; Faura, Carles Adelantado; Schönlau, Frank; Rohdewald, Peter

doi:10.1002/ptr.1662

Cited by 58 publications

(38 citation statements)

References 3 publications

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“…In the present study, we aimed to investigate the effects of Pycnogenol, also known as Pinus pinaster bark extract, on peritoneal adhesions; the antioxidant, antimicrobial, and antiinflammatory effects of Pycnogenol have been reported in the literature in terms of preventing and reducing intra-abdominal adhesions that cause serious complications [8][9][10][11][12] . Additionally, we aimed to investigate the immunohistochemical effects of free oxygen radicals and reactive lymph nodes detected in the adhesive tissue that was sampled surrounding the cecum on intra-abdominal adhesions.…”

Section: ■ Introductionmentioning

confidence: 99%

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

Göret¹,

Göret

Kiraz

et al. 2018

Acta Cir. Bras.

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Purpose: To investigate the effects of pycnogenol on peritoneal adhesions and additionally to investigate the immunohistochemical effects of free oxygen radicals and reactive lymph nodes detected in the adhesive tissue that was sampled surrounding the cecum on intraabdominal adhesions. Methods: Twenty-seven Wistar Albino rats were divided into three groups. In group 1 (sham), laparotomy was performed and stitched up. In group 2 (control), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered 2 cc of saline. In group 3 (experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile Pycnogenol derivative. The rats in all groups were re-laparotomized on postoperative day 7; samples were obtained from the peritoneal tissue surrounding the cecum, and the rats were sacrificed. Results: In group 3, there was a statistically significant difference in terms of inflammation, lymph node size, and free oxygen radicals; these parameters tended to increase. In terms of fibrosis evaluated using H&E and MT, there was no significant difference between groups 2 and 3. Conclusions: No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. However, it caused severe inflammation in the tissue. Moreover, a significant increase in lymph node size was detected secondary to inflammation. Additionally, in immunohistochemical analyses conducted to detect oxidative stress, pycnogenol increased the production of free oxygen radicals in the tissue.

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Section: ■ Introductionmentioning

confidence: 99%

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

Göret¹,

Göret

Kiraz

et al. 2018

Acta Cir. Bras.

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“…Several research groups published the results on antimicrobial activity of PBEs. As opposed to simple aqueous extract (PABE) which was used in this research, in those researches mostly Pycnogenol ® -commercial water/ethanol extract was tested and it was shown that 250 μg ml -1 of Pycnogenol ® counteracted the growth of several tested Gram-positive and Gramnegative bacteria, 13 inhibited growth of Helicobacter pylori in suspension (12.5 μg ml -1 ), while in ten times higher concentration reduced the adherence of the bacterium to gastric cells.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii

Ćurković‐Perica¹,

Hrenović²,

Kugler³

et al. 2015

Croat. Chem. Acta

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Abstract. The aim of this research was to test the antibacterial activity of Pinus pinaster aqueous bark extract (PABE) and its basic components against multidrug-resistant isolates of Acinetobacter baumannii belonging to European clone I and II, isolated previously from the clinical outbreaks. The minimum bactericidal concentration of PABE against both clones of A. baumannii was 200 mg ml -1 , while lower concentrations showed high antibacterial activity. After 24 h of treatment with 100, 50 or 10 mg ml -1 of extract, the reduction in the number of A. baumannii isolates belonging to European clone I and II was 85.8 ± 2.5 %, 78.5 ± 1.1 %, 66.3 ± 2.5 % and 90.2 ± 1.7 %, 78.6 ± 1.2 %, 69.8 ± 0.7 %, respectively. Several basic components: caffeic acid, catechin, epicatechin, gallic acid and vanillin, detected in the extract by high performance liquid chromatography, contributed to the antibacterial activity of the extract against both clones of A. baumannii. However, the antibacterial activity of extract was higher than that of each tested basic component suggesting that proanthocyanidins, which were present in quite a large amount in the extract, might have also contributed to the activity of the extract. Antibacterial activity of PABE against A. baumannii reveals that complex and inexpensive natural product might be useful in combat against naturally competent bacteria that easily acquire resistance against antibiotics.

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“…(Pinaceae), was tested for its antifungal activity towards twenty three different yeast and fungi microorganisms. 43 Pycnogenol inhibited the growth of all the tested microorganisms in minimum concentrations ranging from 20 to 250 µg/ml. These results conform with clinical oral healthcare studies describing the prevention of plaque formation and the clearance of candidiasis by pycnogenol.…”

Section: Crude Extractsmentioning

confidence: 92%

Active antifungal substances from natural sources

Abad¹,

Ansuategui²,

Bermejo³

2006

Arkivoc

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The spread of multidrug-resistant strains of fungus and the reduced number of drugs available, makes it necessary to discover new classes of antifungals and compounds that inhibit these resistant mechanisms. This has led to a search for therapeutic alternatives, particularly among medicinal plants and compounds isolated from them used for their empirically antifungal properties. In these natural sources, a series of molecules with antifungal activity against different strains of fungus have been found, which are of great importance to humans and plants. In this article, we review the main sources of molecules with antimycotic activity obtained from the natural environment.

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Antimicrobial activity of Pycnogenol^®

Cited by 58 publications

References 3 publications

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii

Active antifungal substances from natural sources

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Antimicrobial activity of Pycnogenol®

Cited by 58 publications

References 3 publications

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii

Active antifungal substances from natural sources

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Product

Resources

About

Antimicrobial activity of Pycnogenol^®