Antimicrobial Activity of Se-Nanoparticles from Bacterial Biotransformation

Abstract

Selenium nanoparticles (SeNPs) are gaining importance in the food and medical fields due to their antibacterial properties. The microbial inhibition of these kinds of particles has been tested in a wide range of Gram (+) and Gram (−) pathogenic bacteria. When SeNPs are synthesized by biological methods, they are called biogenic SeNPs, which have a negative charge caused by their interaction between surface and capping layer (bioorganic material), producing their high stability. This review is focused on SeNPs synthesis by bacteria and summarizes the main factors that influence their main characteristics: shape, size and surface charge, considering the bacteria growth conditions for their synthesis. The different mechanisms of antimicrobial activity are revised, and this review describes several biosynthesis hypotheses that have been proposed due to the fact that the biological mechanism of SeNP synthesis is not fully known.

Selenium accumulation by Lactobacillus isolated from commercial fermented milk: minimum inhibitory concentration and kinetic growth changes

“…johnsonii La1 in the supplemented medium was presented in the non-enriched medium (10 h and 12 h, respectively). It is known that some LAB activates metabolic processes in the presence of salts such as Na 2 SeO 3 due to the detoxification mechanism (Escobar-Ramírez et al, 2021). However, the cell concentration was higher in media without supplementation, which coincides with the results reported by Martínez et al (2020).…”

“…In contrast, the accumulation of selenium in enriched media at a higher concentration of the MIC is related to the transformation of selenite to elemental selenium deposited near the cell membrane (Kousha et al, 2017). Escobar-Ramírez et al (2021) reported that selenium accumulated in the cell periphery is accumulated simultaneously in the periplasm, especially in those bacteria producing seleno nanoparticles. However, in different cases, the Se bioaccumulation has not affected the cellular growth, specifically in the stationary phase.…”

Designated functional microcapsules loaded with green synthesis selenium nanorods and probiotics for enhancing stirred yogurt

“…Which, two genes SelA and SelD are located in the probiotic strains genome and involved in Se metabolism 62 , 63 . So, the helpful effect of nanoparticles delivered to the gut microbiota, aiming to reduce the pathogens, by eliminated the growth of harmful microbes and improved beneficial bacteria as probiotics 64 , 65 .…”

Green Orange Peel-Mediated Bioinspired Synthesis of Nanoselenium and Its Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus

“…Several experiments on bacteria using transmission electron microscopes have shown that SeNPs permeate the cells, supporting this claim. , Furthermore, in the presence of oxygen and proton, SeNPs break down to ions, making infusion easier . When SeNPs enter the cell, they interact with biological components and structures such as proteins, deoxyribonucleic acid (DNA), and lipids . For example, SeNPs disrupt protein synthesis by binding with the ribosome and denaturing it, causing the translation process to cease .…”

“… 82 When SeNPs enter the cell, they interact with biological components and structures such as proteins, deoxyribonucleic acid (DNA), and lipids. 83 For example, SeNPs disrupt protein synthesis by binding with the ribosome and denaturing it, causing the translation process to cease. 84 SeNPs also interact with DNA molecules, which can result in DNA denaturation and shearing, as well as cell division disruption.…”