Antimicrobial activity of sophorolipids against Eimeria maxima and Clostridium perfringens, and their effect on growth performance and gut health in necrotic enteritis

Park, Inkyung; Oh, Seong-Hwan; Nam, Hyoyoun; Celi, Pietro; Lillehoj, Hyun S.

doi:10.1016/j.psj.2022.101731

Cited by 13 publications

(16 citation statements)

References 53 publications

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“…6 E–H). SL treatment has been shown to promote leakage of cytoplasmic components in both budding cells and hyphae forms of C. albicans in the extracellular matrix of biofilm [ 11 , 12 ]. The actions of SLs are suggested to be related to the synergistic interactions between the fatty acid and sophorose congeners [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

“…Biosurfactant applications in other industries like food, cosmetics, medical, and pharmaceuticals, gradually apply these biomolecules. One of the most prominent biosurfactants, namely SLs, has broad antimicrobial activity against pathogenic fungi, bacteria, and parasites [1,[11][12][13][14][15][16][17]. Basically, SLs derived from S. bombicola ATCC 22,214 have different antimicrobial actions depending on the SL types.…”

Section: Open Accessmentioning

confidence: 99%

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Production of new antimicrobial palm oil-derived sophorolipids by the yeast Starmerella riodocensis sp. nov. against Candida albicans hyphal and biofilm formation

et al. 2022

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Background Microbial derived-surfactants display low eco-toxicity, diverse functionality, high biodegradability, high specificity, and stability under extreme conditions. Sophorolipids are emerging as key biosurfactants of yeast origins, used in various industrial sectors to lower surface tension. Recently, sophorolipid complexes have been applied in biomedicals and agriculture to eradicate infectious problems related to human and plant fungal pathogens. This study aimed to characterize the functional properties and antifungal activities of sophorolipids produced by a newly characterized Starmerella riodocensis GT-SL1R sp. nov. strain. Results Starmerella riodocensis GT-SL1R sp. nov. strain was belonged to Starmerella clade with 93.12% sequence similarity using the ITS technique for strain identification. Sophorolipids production was examined, using co-carbon substrates glucose and palm oil, with a yield on the substrate between 30 and 46%. Using shake-flasks, the S. riodocensis GT-SL1R strain produced biosurfactants with an emulsification activity of 54.59% against kerosene compared to the S. bombicola BCC5426 strain with an activity of 60.22%. Maximum productivities of GT-SL1R and the major sophorolipid-producer S. bombicola were similar at 0.8 gl−1 h−1. S. riodocensis GT-SL1R produced mixed forms of lactonic and acidic sophorolipids, shown by TCL, FTIR, and HPLC. Importantly, the complex sophorolipid mixture displayed antifungal activity against an opportunistic yeast pathogen Candida albicans by effectively reducing hyphal and biofilm formation. Conclusions Sophorolipids derived from S. riodocensis demonstrate potential industrial and biomedical applications as green surfactant and antifungal agent. Since numerous renewable bioresources and industrial wastes could be used by microbial cell factories in the biosynthesis of biosurfactants to reduce the production cost, sophorolipids hold a promising alternative to current antimicrobials in treatments against infectious diseases in humans, animals, and plants.

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Section: Discussionmentioning

confidence: 99%

Section: Open Accessmentioning

confidence: 99%

Production of new antimicrobial palm oil-derived sophorolipids by the yeast Starmerella riodocensis sp. nov. against Candida albicans hyphal and biofilm formation

et al. 2022

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“…However, in the current study, dietary SL supplementation up to 200 ppm revealed no harmful effects on the growth of young broiler chickens. A previous study also demonstrated the dietary safety of up to 200 ppm of SLs, which showed growth- and immune-promoting effects of chickens affected by necrotic enteritis ( Park et al, 2022 ).…”

Section: Discussionmentioning

confidence: 86%

“…Total RNA from the jejunal samples was prepared by the protocol as previously described ( Park et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Effect of dietary sophorolipids on growth performance and gastrointestinal functionality of broiler chickens infected with Eimeria maxima

Park

Goo

et al. 2022

Poultry Science

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“…Moreover, the combination of living Bifidobacterium and Lactobacillus mitigates anxiety- and depression-like behaviors in mice [ 87 ]. On a separate note, Clostridium perfringens is a class of harmful bacteria present in the gut [ 88 ], which can lead to intestinal dysbacteriosis [ 89 ]. We then detected the DNA relative contents of four intestinal bacteria.…”

Section: Discussionmentioning

confidence: 99%

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Cao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Okra, possessing various bioactive components, is used to treat different diseases. This study sought to estimate the intervention effects of okra extract (OE) on brain-gut peptides (BGPs) and intestinal microorganisms in sleep deprivation (SD) rats. Methods. SD rat models were established using the modified multiple platform method and then treated with normal saline, diazepam tablets, or different doses of OE. Body weight and average daily water consumption of rats were recorded. Depressive behaviors of rats were assessed by the open field test and sucrose preference test. Serum levels of noradrenaline, melatonin, inflammatory factors (IL-1β/IL-6/TNF-α/IL-4/IL-10), and BGP indexes, including gastrin (GAS), motilin (MTL), 5-hydroxytryptamine (5-HT), cholecystokinin (CCK), and vasoactive intestinal peptide (VIP) were measured by ELISA. Additionally, the DNA relative contents of representative intestinal microorganisms in the collected rat feces were determined using RT-qPCR. Results. SD decreased body weight and average daily water consumption and induced depressive behaviors as well as stress and inflammatory responses in rats. SD rats exhibited lowered GAS, MTL, 5-HT, and VIP but elevated CCK and showed diminished DNA relative contents of Bacteroidetes and probiotics (Bifidobacteria and Lactobacilli) but increased Clostridium perfringens. OE at different doses ameliorated the depressive behaviors and mitigated the stress and inflammatory responses in SD rats, raised the serum contents of GAS, MTL, 5-HT, and VIP, reduced CCK level, elevated the DNA relative contents of Bacteroidetes and probiotics, but diminished Clostridium perfringens. OE exhibited similar intervention effects to diazepam tablets (positive control). Conclusion. OE exerts intervention effects on BGPs and intestinal microorganisms in SD rats.

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Antimicrobial activity of sophorolipids against Eimeria maxima and Clostridium perfringens, and their effect on growth performance and gut health in necrotic enteritis

Cited by 13 publications

References 53 publications

Production of new antimicrobial palm oil-derived sophorolipids by the yeast Starmerella riodocensis sp. nov. against Candida albicans hyphal and biofilm formation

Production of new antimicrobial palm oil-derived sophorolipids by the yeast Starmerella riodocensis sp. nov. against Candida albicans hyphal and biofilm formation

Effect of dietary sophorolipids on growth performance and gastrointestinal functionality of broiler chickens infected with Eimeria maxima

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

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