Antimicrobial activity of the crude extract, fractions and compounds from stem bark of Ficus ovata (Moraceae)

Kuete, Victor; Nana, Frédéric; Ngameni, Bathélémy; Mbaveng, Armelle T.; Keumedjio, Félix; Ngadjui, Bonaventure T.

doi:10.1016/j.jep.2009.05.003

Cited by 103 publications

(94 citation statements)

References 32 publications

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“…It should be highlighted that the E. coli isolate used herein shows resistance to fluoroquinolones (levofloxacin and ciprofloxacin) and ampicillin, being intermedia for amoxicillin/clavulanic acid. Kuete et al (2009) reported a MIC = 78 lg ml À1 for protocatechuic acid isolated from Ficus ovata against E. coli (b-lactamases positive). The observed difference in MIC values could be related to the use of strains with different susceptibility profiles.…”

Section: Resultsmentioning

confidence: 99%

“…Korea Kim et al (2008) (Continued) Although the antimicrobial activity of extracts from several mushroom species has been reported (Barros et al 2007;Quereshi et al 2010;Ozen et al 2011;Alves et al 2012), studies with the individual compounds present in that extracts are scarce, being mainly related to phenolic compounds identified in plant sources (Kuete et al 2009;Orhan et al 2010;Lou et al 2012).…”

Section: Obliquusmentioning

confidence: 99%

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Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies

et al. 2013

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Aim and Methods: Although the antimicrobial activity of extracts from several mushroom species has been reported, studies with the individual compounds present in that extracts are scarce. Herein, the antimicrobial activity of different phenolic compounds identified and quantified in mushroom species from all over the world was evaluated. Furthermore, a structure-activity relationship (SAR) analysis and molecular docking studies were performed, in order to provide insights into the mechanism of action of potential antimicrobial drugs for resistant micro-organisms. Results: 2,4-Dihydroxybenzoic and protocatechuic acids were the phenolic compounds with higher activity against the majority of Gram-negative and Gram-positive bacteria. Furthermore, phenolic compounds inhibited more MRSA than methicillin-susceptible Staphylococcus aureus. MRSA was inhibited by 2,4-dihydroxybenzoic, vanillic, syringic (MICs = 0Á5 mg ml À1 ) and p-coumaric (MIC = 1 mg ml À1

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Section: Resultsmentioning

confidence: 99%

Section: Obliquusmentioning

confidence: 99%

Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies

et al. 2013

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“…The assay was repeated thrice. The MICs of samples were detected following addition (40 µL) of 0.2 mg/mL p-iodonitrotetrazolium chloride and incubated at 37°C for 30 min (Kuete et al, 2009a, b). The MIC corresponded to the greatest dilution of sample in which the color shift from yellow to pink was not observed For the determination of MMC, a portion of liquid (5 µL) from each well that showed no change in color was plated on MHA and incubated at 30°C for 48 h (M. audouinii) or 37°C for 24 h (other organisms).…”

Section: Sensitivity Test: Agar Disc Diffusion Assaymentioning

confidence: 99%

Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark ofAllanblackia floribunda

Kuete

Azebaze

Mbaveng

et al. 2010

Pharmaceutical Biology

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“…Ficus species have also been used in Indian ayurvedic and traditional medicine (Joseph and Justin Raj, 2010). Extracts of Ficus species have also been documented to have antioxidant, antidiabetes, antibacterial, antifungal, antiviral, anti-protozoal, anticancer, cytotoxic, anti-ulcer, anti-inflammatory, anti-hyperglycemic, antidiarrhoea, hepato-protective, muco-protective and gastro-protective activity (Kuete et al, 2009 (Burrows and Burrows, 2003). In Botswana, both adults and children eat the fresh ripe fruits (Daniel and Topo, 2012).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Anti-Biofilm Activity of Flavonoids and Triterpenes Isolated from The Extracts of <i>Ficus Sansibarica</i> Warb. <i>Subsp. Sansibarica</i> (Moraceae) Extracts

Awolola¹,

Koorbanally²,

Chenia³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Ficus species are used in African traditional medicine in the treatment of a wide variety of ailments and diseases such as convulsive disorder, wound healing, gonorrhea, tuberculosis, diabetes, diarrhoeal infections, dysentery, malaria and HIV. The aim of this study was to isolate the phytochemical constituents in the plant and test them for their antibacterial activity. Materials and methods: The fruits, leaves and stem bark were extracted with organic solvents and the compounds in the extracts separated and purified by column chromatography before being identified by NMR spectroscopy and by comparison of the NMR data against values reported in the literature. The antibacterial activity of the pure compounds and extracts were tested using the disk diffusion method. Results: Three triterpenes and three flavonoids: lupeol acetate (1); cycloart-23-ene-3,25-diol (2); β-sitosterol (3); 5,7,4'-trihydroxyflavan-3-ol (4); epicatechin (5); and isovitexin (6) were isolated in this study. Antimicrobial activity was observed at 8 mg mL -1 for Staphylococcus aureus ATCC 29213 with four of the six isolated compounds, with no activity being observed at 1 -4 mg mL -1 against Escherichia coli ATCC 25922, E. coli ATCC 35218 and S. aureus ATCC 43300. Epicatechin (5) was found to decrease adhesion of E. coli ATCC 25922 and S. aureus ATCC 29213. Decreased adhesion of S. aureus ATCC 29213 was also observed with 5,7,4'-trihydroxyflavan-3-ol (4) and isovitexin (6). Conclusions:The results of this study provide baseline information on F. sansibarica's potential validity in the treatment of infections associated with Gram-positive microorganisms.

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Antimicrobial activity of the crude extract, fractions and compounds from stem bark of Ficus ovata (Moraceae)

Cited by 103 publications

References 32 publications

Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies

Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies

Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark ofAllanblackia floribunda

Antibacterial and Anti-Biofilm Activity of Flavonoids and Triterpenes Isolated from The Extracts of <i>Ficus Sansibarica</i> Warb. <i>Subsp. Sansibarica</i> (Moraceae) Extracts

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