Antimicrobial activity of the extracts and physalin D from<i>Physalis alkekengi</i>and evaluation of antioxidant potential of physalin D

Helvacı, Şehnaz; Kökdil, Gamze; Kawai, Maki; Duran, Nizami; Duran, Gülay Gülbol; Güvenç, Ayşegül

doi:10.3109/13880200903062606

Cited by 75 publications

(44 citation statements)

References 39 publications

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“…It was shown that the dichloromethane extract and physalin D had low activity against fungi, at MIC values ranging from 256 to 512 µg/ml. Additionally, the antioxidant activity of physalin D was evaluated by qualitative DPPH radical-scavenging and thiobarbituric acid-reactive substance (TBARS) assays, showing low antioxidant activity with an IC 50 value of ≥10 ± 2.1 μg/mL [79]. …”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacological Study of Medicinal Plants Used for Treating Dysuria: A Collection from Traditional Markets in Shiraz

et al. 2018

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Background: Data from the ethnopharmacological field on the treatment of dysuria are provided and analyzed with regard to traditional healers from Shiraz and in comparison to previous studies. Material and Methods: From April 21 to June 25, 2014, we visited traditional markets called Attari in Shiraz, and plants used in dysuria were collected. Questionnaires asking for general information on the traditional healers named Attars, local names of plant species, plant parts, preparation methods, etc. were prepared in order to gather data from Attars. Results: We visited 40 Attari, and 29 questionnaires were filled in by male Attars. Evaluation of our investigation revealed that Tribulus terrestris, Zea mays, and Cerasus avium were the most common plants suggested by Attars (24, 23, and 23, respectively). Infusion (37%) and decoction (34%) were the most common preparation methods for these plants. 50% of the main effects intended by the Attars were antimicrobial effects, while diuretic effects were reported at 35.7%. The temperament of the plants, as one aspect of the questionnaires, showed that more plants have a hot and dry temperament (47.9%). According to available studies about the plants, we found that flavonoids (78.3%), higher terpenoids (43.5%), and essential oils (39.1%) exist in higher amounts than other components in the plants. Conclusions: We analyzed the information gathered from the questionnaires and from previous studies and found that flavonoids are the most important constituents among the plants, especially those that exist in T. terrestris, Z. mays, and C. avium. Due to the useful effects of flavonoids in urological diseases, we suggest to evaluate and concentrate on the effects of flavonoids in dysuria treatments.

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Section: Resultsmentioning

confidence: 99%

Ethnopharmacological Study of Medicinal Plants Used for Treating Dysuria: A Collection from Traditional Markets in Shiraz

et al. 2018

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“…Physalin D yielded a quasimolecular ion with an m/z 544. 9 [M+H] + , while the IS molecule showed a quasi-molecular ion with m/z 286.7 [M+H] + and these ions were chosen as parent ions for fragmentation in the MRM mode. The product ions m/z 508.8 and m/z 152.8 were selected as the target ions of physalin D and IS, respectively.…”

Section: Optimization Of Ms Conditionsmentioning

confidence: 99%

“…Januário et al's research showed that physalin D plays a relevant role in the antimycobacterial activity [2]. Other studies showed that physalin D also has immune depression [6], cytotoxic [1,7,8] and antimicrobial [9] activities. All these activities suggested that physalin D may be a good lead compound for further new drug studies.…”

Section: Introductionmentioning

confidence: 99%

Plasma pharmacokinetics and tissue distribution study of physalin D in rats by ultra-pressure liquid chromatography with tandem mass spectrometry

Zheng

Chen

et al. 2011

Journal of Chromatography B

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“…middle ear infection, sore throat, abscesses, and urinary problems (Helvaci et al, 2010). Research has found that PA contains physalins, flavonoids, alkaloids and megastigmane glycosides (Qiu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of Physalis alkekengi L. var. franchetii extract and its chloroform fraction on LPS or LPS/IFN-γ-stimulated inflammatory response in peritoneal macrophages

Kang

Kwon

Choi

2011

Journal of Ethnopharmacology

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Antimicrobial activity of the extracts and physalin D fromPhysalis alkekengiand evaluation of antioxidant potential of physalin D

Cited by 75 publications

References 39 publications

Ethnopharmacological Study of Medicinal Plants Used for Treating Dysuria: A Collection from Traditional Markets in Shiraz

Ethnopharmacological Study of Medicinal Plants Used for Treating Dysuria: A Collection from Traditional Markets in Shiraz

Plasma pharmacokinetics and tissue distribution study of physalin D in rats by ultra-pressure liquid chromatography with tandem mass spectrometry

Inhibitory effect of Physalis alkekengi L. var. franchetii extract and its chloroform fraction on LPS or LPS/IFN-γ-stimulated inflammatory response in peritoneal macrophages

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