Antimicrobial activity of various ethanolic plant extracts against pathogenic multi drug resistant Candida spp.

Khan, Shaista Jabeen; Imran, Mohd; Imran, Mohammed; Pindari, Nuzhat

doi:10.6026/97320630013067

Cited by 29 publications

(20 citation statements)

References 35 publications

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“…The findings of this study suggest that the aqueous and ethanolic leaf extracts of leaves of S. grandiflora is found to be most effective and potent source which can be used as alternative antimicrobial compounds. Our antifungal analyses are in agreement with the reports 35 against 15 Candida spp with ethanolic extracts of Allium sativum, Azadirachta indica, Cordia dichotoma and Ocimum sanctum which resulted in significant inhibition zones. Antifungal activities of some herb and spices have also been reported against Candida 36 .…”

Section: Materials and Methods: Collection Of Plant Materialssupporting

confidence: 92%

Untitled

2018

IJPSR

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The positive results of screening medicinal plants for antimicrobial activity forms primary platform for phytochemical and pharmacological studies in future. The work was undertaken to evaluate the antimicrobial activity of four medicinal plants viz., Sesbania grandiflora, Epiphyllum oxypetalum, Nyctanthes arbor-tristis, and Vetiveria zizanioides. Leaves were extracted using water and ethanol as solvents. The antimicrobial activity was assessed against five bacterial and fungal pathogens like Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Enterobacter aerogenes and Aspergillus flavus, Aspergillus niger, Cladosporium cladosporioides, Fusarium monoliforme, Penicillium sp. Aqueous extracts of S. grandiflora was found to be most effective in inhibiting B.subtilis (23 ± 0.66) while ethanolic extracts showed N. arbor-tristis inhibiting S.typhi (20 ± 0.35). Further aqueous extracts of S. grandiflora showed considerable effect of inhibition against Penicillum sp. (22.63 ± 0.60) whereas ethanol extracts of S. grandiflora was most efficient against Penicillium sp. (24 ± 0.33). All the other plants extracts were also effectual to remarkable extent. The present investigation has thrown a light on the effect of ethanolic leaf extracts of S. grandiflora and N. arbor-tristis against the selected microorganisms which can be further subjected to purification which may act as alternative for synthetic compounds in especially antioxidants and antimicrobial drugs.

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Section: Materials and Methods: Collection Of Plant Materialssupporting

confidence: 92%

Untitled

2018

IJPSR

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“…may possess specific biological activities against many pathogenic microorganisms. Chemical extraction processes from plants, e.g., those using aqueous or organic solvents or supercritical fluid extraction, may sometimes influence not only the concentration of the active compounds, but also the presence of toxic metabolites ( Scur et al, 2016 ; Silva et al, 2016 ; Arbia et al, 2017 ; Khan et al, 2017 ; Petrovic et al, 2017 ; Rosas-Burgos et al, 2017 ; Thielmann et al, 2017 ; Zbikowska et al, 2017 ). The use of the edible part of plants could minimize this problem, especially when this product has been used for 100s of years in human alimentation, as is the case for lentisk oil.…”

Section: Discussionmentioning

confidence: 99%

The Selective Interaction of Pistacia lentiscus Oil vs. Human Streptococci, an Old Functional Food Revisited with New Tools

et al. 2017

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Pistacia lentiscus berry oil (LBO) represents a typical vegetal product of the Mediterranean basin that has been formally used in traditional cuisine for 100s of years. In addition to its interesting alimentary properties, this product could represent an interesting candidate in the field of research on the study of new anti-infective agents. In fact, in Mediterranean countries, lentisk oil still continues to be widely used in folk medicine for oral and skin affections, in particular, acute gingivitis, pediatric skin infections such as impetigo and foot plaques, and biofilm related infections often associated with Streptococcus spp. Following these observations, we have hypothesized a “lentisk oil-bacteria” interaction, placing particular emphasis on the different Streptococcal species involved in these oral and skin diseases. In accordance with this hypothesis, the use of standard antimicrobial-antibiofilm methods (MIC, MBC, MBIC) allowed the interesting behavior of these bacteria to be observed and, in this context, the response to lentisk oil appears to be correlated with the pathogenic profile of the considered microorganism. Two probiotic strains of S. salivarius K12/M18 appeared to be non-sensitive to this product, while a set of five different pathogenic strains (S. agalactiae, S. intermedius, S. mitis, S. mutans, S. pyogenes) showed a response that was correlated to the fatty acid metabolic pathway of the considered species. In fact, at different times of bacteria development, selective High Performance Liquid Chromatography analysis of the growth medium containing LBO detected a significant increase in free unsaturated fatty acids (UFAs) in particular oleic, palmitic and linoleic acids, which are already known for their antibacterial activity. In this context, we have hypothesized that LBO could be able to modulate the pathogen/probiotic rate in a Streptococcal population using the fatty acid metabolic pathway to help the probiotic strain. This hypothesis was strengthened by performing antibacterial testing with oleic acid and an in silico evaluation of the Streptococcal MCRA protein, an enzyme involved in the production of saturated fatty acids from UFA. These results show that LBO may have been used in ancient times as a “natural microbial modulating extract” in the prevention of biofilm- associated diseases.

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“…The synergistic antibacterial activities of mixtures of O. gratissimum leaf extracts with other plants and O. gratissimum leaf extracts with antibiotics have been documented in earlier studies [5,10,11]. The mixtures of honey and antibiotics have been reported for synergistic effects against species of bacteria [12].…”

Section: Introductionmentioning

confidence: 81%

Synergistic Antibacterial Potentials of Ocimum gratissimum, Honey and Ciprofloxacin against some Multiple Antibiotic-Resistant Bacteria Isolated from Stool Samples

Olawale

Olusola-Makinde

Oladunmoye

2021

Walailak J Sci & Tech

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This study investigated the synergistic antibacterial potentials of Ocimum gratissimum (O. gratissimum) leaf acetone extract, honey, and ciprofloxacin against some multiple antibiotic-resistant bacteria. Multiple antibiotic-resistant bacterial isolates from stool samples of diarrhea patients and their typed cultures were subjected to inhibitory assay by mixtures of extract and honey, extract and ciprofloxacin, honey and ciprofloxacin, and extract, honey and ciprofloxacin using tube dilution method. Killing rate and mechanisms of action of the mixtures on the susceptible pathogens were determined. The multiple antibiotic resistance indices of the test organisms (MARI) ranged from 0.7 to 1.0. Extract, honey, and ciprofloxacin mixture at ratio 1:1:1 exerted the lowest minimum inhibitory concentration on E. coli, P. aeruginosa ATCC 10145, E. coli ATCC 25922, and S. typhi ATCC 14028 at 1.56×10-3 mg/mL compared with ciprofloxacin (3.13×10-3 mg/mL). Highest potassium, sodium, and protein leakage was induced by extract and honey mixture (97.4 cmol/g) in E. coli, extract, honey, and ciprofloxacin mixture (65.2 cmol/g) in B. cereus, and extract, honey, and ciprofloxacin mixture (21.6 mg/mL) in B. cereus, respectively. Extract, honey, and ciprofloxacin mixture exerted highest killing rate on B. cereus after 24 h (1.3×101 cfu/mL). These findings revealed a high synergistic antibacterial potential of O. gratissimum leaf acetone extract, honey, and ciprofloxacin against multiple drug-resistant bacteria, thus, implying their potential use in diarrhea treatment.

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Antimicrobial activity of various ethanolic plant extracts against pathogenic multi drug resistant Candida spp.

Cited by 29 publications

References 35 publications

Untitled

Untitled

The Selective Interaction of Pistacia lentiscus Oil vs. Human Streptococci, an Old Functional Food Revisited with New Tools

Synergistic Antibacterial Potentials of Ocimum gratissimum, Honey and Ciprofloxacin against some Multiple Antibiotic-Resistant Bacteria Isolated from Stool Samples

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