Antimicrobial Agents in Transurethral Prostatic Resection

Grabe, Magnus

doi:10.1016/s0022-5347(17)43109-0

Cited by 88 publications

(44 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Duration of postoperative antibiotic treatment has been reported to range from 24 hours to 10 days [5][6][7]13,17,[20][21][22]. A common recommendation in these studies is to continue antimicrobial therapy at least until removal of indwelling catheters.…”

Section: Urological Proseduresmentioning

confidence: 99%

“…Screening and treatment of asymptomatic bacteriuria in pregnant women and before some urological procedures has been recommended in the guidelines of the Infectious Diseases Society of America (IDSA) [2]. Preoperative bacteriuria was shown to increase the severe infectious complications such as bacteremia, septicemia, and upper urinary tract infection, especially following various urological interventions [3][4][5][6]. Accordingly, many studies have shown that appropriate antimicrobial treatment preoperatively and postoperatively could decrease the occurrence of these severe infectious complications [5,7,8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is short course of antimicrobial therapy for asymptomatic bacteriuria before urologic surgical procedures sufficient?

Kutlu

Aybek

Tekin

et al. 2011

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Duration of treatment of asymptomatic bacteriuria for patients undergoing urologic surgical procedures is undetermined. We compared the efficacy of long-versus short-course antimicrobial treatment in patients with asymptomatic bacteriuria undergoing urologic surgical procedures. Methodology: Patients were divided into two groups according to duration of antimicrobial treatment. Group A patients received a single dose of an appropriate antibiotic, determined by antimicrobial sensitivity testing, 30 to 60 minutes before the surgical procedure. If a urinary catheter was placed postoperatively, a second dose was given following the recommended dose interval. Group B patients received antimicrobial treatment prior to surgery at least until patient urine became sterile. All patients were monitored for signs and symptoms of septicemia following surgical procedures. Results: None of the patients enrolled in the study developed infectious complications such as sepsis or upper urinary tract infection. In group A, 31 patients were treated with antimicrobials before 39 urological procedures. In group B, the mean treatment time for 28 patients before 30 urological procedures was 8.03 ± 3.86 days. There were also significant differences in length of stay and the cost of antimicrobial therapy between the groups (P < 0.0001). Isolation of an increased number of resistant microorganisms was associated with long course therapy in group B. Conclusions: Short course therapy protocol may be a practical, simple approach for antibiotic use; it decreases hospital stays, eliminates delayed procedure times, lowers the economic cost of antimicrobials and lessens the chance of superinfection with and spread of antimicrobial resistant microorganisms.

show abstract

Section: Urological Proseduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is short course of antimicrobial therapy for asymptomatic bacteriuria before urologic surgical procedures sufficient?

Kutlu

Aybek

Tekin

et al. 2011

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Surgery for benign prostatic hyperplasia is a frequently performed operation in men ^,65 years [1 ]. Transient bacteremia associated with prostatectomy has been reported in about 10-30% of patients not receiving antibacterial agents [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Bacteremia Resulting from Prostatic Surgery in Patients with or without Preoperative Bacteriuria under Perioperative Antibiotic Use

Ohkawa¹,

Shimamura²,

Tokunaga³

et al. 1993

Chemotherapy

View full text Add to dashboard Cite

We investigated the source of organisms detected in blood specimens obtained during and immediately following prostatic surgery under perioperative antibiotic use, as related to the results of cultures of preoperative urines and prostatic tissues. Ninety patients with benign prostatic hyperplasia were studied. The incidence of bacteremia was 28.9%: 53.7% in patients with preoperative bacteriuria and 8.2% in those without bacteriuria, a significant difference (p < 0.01). Of these bacteremic patients, 5, who had preoperative bacteriuria, developed septicemia. Bacteremia developed more frequently in patients with positive than in those with negative prostatic cultures; this difference was significant (p < 0.05). The species in 80.8% of the isolates from blood specimens were identical with those isolated from preoperative urines, and the species in 53.8% were identical with those from prostatic tissues. These results indicate that in patients with urogenital infection, especially bacteriuria, septicemia can result from prostatic surgery even under perioperative antibiotic use. The incidence of postoperative bacteriuria was approximately 20% in the preoperative nonbacteriuric patients regardless of the duration of chemo-prophylaxis.

show abstract

“…4,6,10 Recognized sources of infection include urethral bacterial flora, urethral catheters, intra-operative or postoperative surgical contamination, and infection transferred from a distant sites. 8,[11][12][13][14][15] Moreover, factors which can contribute to increase in risk of post-TURP UTI include presence of preoperative infected urine, indwelling catheter, advanced age, anatomic abnormalities of the urinary tract, smoking, immune-suppression and prolonged hospitalization. 5,13,16,17 There is strong evidence supporting the use of prophylactic antibiotics prior to TURP procedure.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Antibiotic Prophylaxis Prescribing Patterns for TURP: A Need for Canadian Guidelines?

Lawson

Rudzinski

Vicas

et al. 2013

CUAJ

View full text Add to dashboard Cite

Background: While antibiotic prophylaxis is recommended to all patients undergoing transurethral resection of prostate (TURP), little data exist regarding prescribing patterns of urologists prior to this procedure. Here, we sought to determine real-world antibiotic prophylaxis prescribing patterns at a high volume Canadian institution and determine compliance rates to recommendations put forth by the American Urological Association's (AUA) Best Practice Statement (BPS) on antimicrobial prophylaxis. Methods: A retrospective chart review of 488 patients undergoing TURP was conducted. Electronic medical records were reviewed to determine antibiotics prescribed 3 hours preoperatively and 24 hours postoperatively. For patients without a catheter, compliance was defined as those receiving an antibiotic prior to TURP. In patients with an indwelling catheter, compliance was defined as those receiving antibiotics from two different classes prior to surgery. Results: Overall, a total of 30 antibiotic regimens were utilized. The most common single antibiotic regimens prescribed were ciprofloxacin (32%), cefazolin (25%) and gentamicin (3%). In those patients with indwelling Foley catheters prior to TURP, a significant increase in gentamicin, as well as combination antibiotic regimens, was noted. The compliance rate with the AUA BPS in patients without a preoperative catheter was 81%, while the compliance rate for patients with an indwelling catheter prior to TURP was 37%. Interpretation: Collectively, our results demonstrate that prescribing patterns vary significantly prior to TURP, with compliance to AUA BPS being lower than anticipated. Overall, these results support educational efforts in this area, and the development of Canadian recommendations to improve uptake by practicing urologists.

show abstract

Antimicrobial Agents in Transurethral Prostatic Resection

Cited by 88 publications

References 66 publications

Is short course of antimicrobial therapy for asymptomatic bacteriuria before urologic surgical procedures sufficient?

Is short course of antimicrobial therapy for asymptomatic bacteriuria before urologic surgical procedures sufficient?

Bacteremia Resulting from Prostatic Surgery in Patients with or without Preoperative Bacteriuria under Perioperative Antibiotic Use

Assessment of Antibiotic Prophylaxis Prescribing Patterns for TURP: A Need for Canadian Guidelines?

Contact Info

Product

Resources

About