Antimicrobial and ACE Inhibitory Activities of Citrus unshiu Fermented with Lactic Acid Bacteria

최소연,; 김시경,; 윤은영,; 강대욱,; 최낙식,; 문미선,; 이승철,

doi:10.3746/jkfn.2015.44.7.1084

Cited by 8 publications

(1 citation statement)

References 24 publications

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“…The Lactobacillus plantarum used in these experiments is widely used as a probiotic, and these lactic acid bacteria can be easily found not only in nature, but also in fermented foods and animal intestines (Chang et al 2010;Choi et al 2015). L. plantarum is used for antimicrobial activity, ACE (angiotensin-converting enzyme) inhibition, lipid metabolism, and hair growth (Axling et al 2012;Joo 2011;Lee et al 2012).…”

Section: Introductionmentioning

confidence: 99%

The effect of Lactobacillus plantarum hydrolysates promoting VEGF production on vascular growth and hair growth of C57BL/6 mice

Woo

Kim

et al. 2019

J Anal Sci Technol

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Purpose: Angiogenesis is critical in various biological processes, such as blood vessel growth, fetal differentiation, wound healing, and organ regeneration. Various growth factors have been associated with vascular regeneration, including insulin-like growth factor 1 (IGF-1), transforming growth factor-β (TGF-β), and basic fibroblast growth factor (bFGF). One of the most important mediators of vascular regeneration is vascular endothelial growth factor (VEGF). VEGF is known to increase vascular permeability, induce the proliferation of endothelial cells, and stimulate capillary formation in vivo, which are core angiogenic functions. Methods: The hydrolysates of lactic acid bacteria were produced by hydrolyzing Lactobacillus plantarum with proteases, treated with MG-63 osteoblasts, and screened to obtain samples with an excellent VEGF production effect. These samples were applied to human dermal papilla cells (hDPC) to examine the correlation between cell growth and VEGF secretion. Furthermore, the hair growth rate was measured in hair growth experiments using C57BL/6 male mice. Results: The hydrolysates of the lactic acid bacteria produced in this study produced hair growth superior to the growth obtained with 5% minoxidil in hair growth experiments using C57BL/6 male mice. Conclusions: This study aims to develop a material for application to the scalp that promotes angiogenesis in the scalp and facilitates the exchange of nutrients and wastes in the follicles to promote hair growth.

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