Antimicrobial and Anti-Inflammatory Activity of Press Cake of Jatropha curcas

Abstract

Several compounds present in fruits as Polyphenol, are able to kill or inhibit the growth of microorganisms. These properties are relevant mainly in tropical areas, as Amazonian region where infectious are highly prevalent. Therefore, this study investigated the antimicrobial activity of Jatropha curcas seed cake against microorganisms. The results showed antibacterial effect of Jatropha curcas seed cake methanolic extracts on two Gram-positive bacteria and Gram-negative bacteria. Effect of Jatropha curcas seed cake on Superoxide and nitric oxide production was also estimated in macrophage cells. This result suggests its anti-inflammatory and antibacterial potential of the herb, which could be due to the bio-active principles which are anti-inflammatory and antibacterial in nature. The present study, therefore emphasizes the use of Jatropha curcas seeds as an anti-inflammatory and antibacterial drug against macrophage cells and bacteria respectively.

Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics

“…Individually, methanolic extract exhibited the highest activity against S. aureus , S. aureus ATCC and MRSA4 among the clinical isolates, reference or MDR strains, respectively. Methanolic extracts of a number of medicinal plants had previously been reported with higher antimicrobial potential compared to n -hexane and aqueous extracts (Haq et al 2016; Tripathi et al 2016), suggesting its higher biological significance. This study also affirmed the antimicrobial potency of methanolic extract by molecular docking studies that unveiled beta-monolaurin as the best conformation in the active pocket of potential antimicrobial MurF target.…”