Antimicrobial and Anti-Inflammatory Activity of Some Lathyrus L. (Fabaceae) Species Growing In Turkey

Heydari, Hassan; Saltan, Gülçin; Eryılmaz, Müjde; Açıkara, Özlem Bahadır; Sarıaltın, Sezen Yılmaz; Tekin, Mehmet; Çoban, Tülay

doi:10.4274/tjps.86719

Cited by 8 publications

(12 citation statements)

References 12 publications

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“…The total phenolic content was measured from a calibration curve (R 2 = 0.9811) and final values were expressed as mg gallic acid equal per 100 g extract. For all samples, each test was repeated thrice (Heydari, Saltan, Acikara, 2015).…”

Section: Determination Of Total Phenolic Contents Of the Extractsmentioning

confidence: 99%

Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract

Okur

Özbek

Polat

et al. 2018

Braz. J. Pharm. Sci.

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Caper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant are used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and antifungal. The aim of this study is to evaluate potential hypoglycemic effect of C. ovata var. palaestina extracts in alloxan-induced diabetic mice. For this purpose; diabetic mice were administered with 100, 300, 500 mg/kg (i.p.) doses of methanol extract of bud and fruit. Blood glucose levels were screened 60, 120, 240 and 360 min. after treatment. Furthermore, high resolution mass spectrometry (HRMS) analysis, ABTS and DPPH free radical scavenging activity test, and phenolic and flavonoid compounds analysis of extracts were carried out. The data obtained from in vivo study revealed that fruit-methanol 500 mg/kg (FM3), bud-methanol 300 mg/kg (BM2), bud-methanol 500 mg/kg (BM3) extracts showed significant hypoglycemic activity. All extracts indicated significant antioxidant activity, however bud-methanol (BM) extract demonstrated the most potent antioxidant activity. Moreover high levels of phenolic substances and flavonoids were involved in all extracts, but the highest levels were found in FM extract. HRMS study showed that rutin, quercetin 3-O-glucoside (isoquercitrin) and stachydrine substances had seen in BM extract. The results of this study showed that the C. ovata var. palaestina extracts which, indicate hypoglycemic, antioxidant activities, might provide additional support in diabetes.

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Section: Determination Of Total Phenolic Contents Of the Extractsmentioning

confidence: 99%

Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract

Okur

Özbek

Polat

et al. 2018

Braz. J. Pharm. Sci.

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“…In the water extracts, this activity was from 77.52 (stems) to 95.36 (leaves) %. Heydari et al (2015) investigated five species of Lathyrus and in some cases, DPPH scavenging activity was up to 90%. The free radical scavenging activity of methanol extracts of Lespedeza bicolor was from 53.54 (stems) to 92.07 (inflorescences) % and water extracts from 70.06 (stems) to 92.55 (leaves) % ( Figure 5).…”

Section: Resultsmentioning

confidence: 99%

DPPH Free Radical Scavenging Activity of Some Fabaceae Lindl. Species

Vergun¹

2020

Agrobiodiversity for Improving Nutrition, Health and Life Quality

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Skif-1 at the flowering stage. Raw material was collected from the experimental collections of M.M. Gryshko National Botanical Garden of the NAS of Ukraine (NBG) in the stage of flowering. Determination of the antioxidant activity of investigated plants conducted by DPPH free radical scavenging activity according to Brand-Williams et al. (1995). The total antioxidant activity of plant whole above-ground part of methanol extracts was from 62.78 (Coronilla varia) to 89.99 (Glycyrrhiza glabra) % and water extracts from 51.28 (Onobrychis grandis) to 90.35 (Lespedeza bicolor) %. Leaf extracts exhibited DPPH scavenging activity in methanol extracts from 63.17 (Trifolium ambiguum) to 93.08 (Onobrychis arenaria) % and water extracts from 57.62 (Coronilla varia) to 95.36 (Lathyrus grandiflorus) %. Stem extracts of investigated plants showed inhibition in methanol extracts from 35.04 (Coronilla varia) to 90.51 (Glycyrrhiza glabra) % and water extracts from 20.35 (Coronilla varia) to 77.52 (Lathyrus grandiflorus) %. DPPH scavenging activity of these plants depended on species and part of plants. Thus, plants from Fabaceae family are a potential source of antioxidant activity that can be used for deep pharmacological investigations for food science.

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“…The antimicrobial effect of the plant extracts against the microorganisms may have been due to the secondary metabolites content of these extracts, like phenolic compounds and saponin, which are reported to be antimicrobial. 3 There are In the study by Heydari et al, 27 the antioxidant activities of these species were investigated by DPPH radical scavenging. In that study, different extracts of Lathyrus species exhibited significant free radical scavenging activity.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Anti-Inflammatory Activity of Some <i>Lathyrus</i> L. (Fabaceae) Species Growing in Turkey

Heydari¹,

Saltan²,

Eryılmaz³

et al. 2019

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In vitro anti-enflamatuvar etki ise insan kırmızı kan hücresi kullanarak membran stabilizasyon yöntemi ile değerlendirilmiştir. Bulgular: Etil asetatlı fraksiyonlar diğer ekstre ve fraksiyonlara göre daha yüksek antimikrobiyal aktivite, sulu fraksiyonlar ise diğer ekstre ve fraksiyonlara göre daha yüksek anti-enflamatuvar aktivite göstermiştir. Ayrıca, L. pratensis'in su fraksiyonu, standart olarak kullanılan asetilsalisilik asit ve diklofenak sodyumdan daha yüksek anti-enflamatuvar aktivite göstermiştir. Sonuç: Elde edilen sonuçlara göre Lathyrus türlerinin ekstreleri ve fraksiyonlarının membran stabilizasyon aktiviteye sahip olup, ve in vivo antienflamatuvar aktivite deneyleri için bir ön çalışma olabileceğini belirtmiştir. Anahtar kelimeler: Anti-enflamatuvar aktivite, antimikrobiyal aktivite, insan kırmızı kan hücresi membran, Lathyrus

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Antimicrobial and Anti-Inflammatory Activity of Some Lathyrus L. (Fabaceae) Species Growing In Turkey

Cited by 8 publications

References 12 publications

Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract

Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract

DPPH Free Radical Scavenging Activity of Some Fabaceae Lindl. Species

Antimicrobial and Anti-Inflammatory Activity of Some <i>Lathyrus</i> L. (Fabaceae) Species Growing in Turkey

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