Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract

Chattopadhyay, Debprasad; Arunachalam, G.; Mandal, Asit Baran; Sur, Tapas Kumar; Mandal, Subash C; Bhattacharya, S. K.

doi:10.1016/s0378-8741(02)00165-4

Cited by 130 publications

(87 citation statements)

References 14 publications

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“…Arg. (Euphorbiaceae) leaf extract (Chattopadhyay et al, 2002) have been shown to exhibit both antimicrobial and anti-inflammatory activities and an ethanol extract of Desmodium caudatum (Thunb.) DC.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and anti-inflammatory properties ofFuntumia elastica

Agyare

Koffuor

Boakye

et al. 2013

Pharmaceutical Biology

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Section: Introductionmentioning

confidence: 99%

Antimicrobial and anti-inflammatory properties ofFuntumia elastica

Agyare

Koffuor

Boakye

et al. 2013

Pharmaceutical Biology

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“…Biological activities of the extracts of the plants belonging to the genus Mallotus, or of individual chemical constituents isolated from these extracts, have been reported by several authors. The aqueous extract of Mallotus pelatus showed a strong antipyretic effect similar to that of paracetamol (Chattopadhyay et al 2002). IshIi et al (2003) reported that phloroglucinol derivatives of Malotus japonicus had been shown to inhibit pro-inflammatory cytokine production.…”

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confidence: 97%

Antioxidant activity of phenolic fractions of Mallotus philippinensis bark extract

Arfan¹,

Amin²,

Karamać³

et al. 2009

Czech J. Food Sci.

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Phenolic compounds were extracted from Mallotus philippinensis bark using methanol. Six fractions (I-VI) were separated from the extract on a Sephadex LH-20 column using ethanol and acetone-water as the mobile phases and were evaluated for their total antioxidant activity, antiradical activity against DPPH• (2,2-diphenyl-1-picrylhydrazyl radical), and reducing power. The total phenolics and tannin contents in the fractions were determined. The content of total phenolics in the fractions ranged from 54 mg/g (fraction I) to 927 mg/g (fraction VI). Condensed tannins were detected in fractions II-VI. Total antioxidant activity (TAA) of phenolic fractions of Mallotus philipinensis bark extract ranged from 0.58 mmol Trolox/g (fraction I) to 6.82 mmol Trolox/g (fraction IV). Fraction IV also showed the strongest antiradical activity against DPPH • and reducing power. Several phenolic constituents in the fractions were detected by RP-HPLC using a gradient solvent system with UV-DAD detection.

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“…The nbutanol part (24 g), were then subjected to Silica-gel CC, eluting with petroleum ether (PE), PE: CHCl 3 , CHCl 3 , CHCl 3 : MeOH (at different ratio) and MeOH. The eluted fractions A (7 g), B (6 g) and C (8 g) were repeatedly Si-gel CC and were monitored by TLC (Trease and Evans, 1983;Chattopadhyay et al, 2002). Out of the three, fraction A was positive to terpenoid, fraction B to phytosterol and the CHCl 3 -MeOH fraction (fraction C) was positive for alkaloid in TLC.…”

Section: Extraction and Fractionationmentioning

confidence: 99%

“…study with few such medicaments showed promising results (Chattopadhyay et al, 1998;Chattopadhyay et al, 2001;Arunachalam et al, 2002;Chattopadhyay et al, 2002). The Genus Ophiorrhiza, sister group of Rubioideae of the family Rubiaceae contain 47 species (Manen and Natali, 1996), of which O. infundibularis Balakr., O. mungos L, O. nicobarica Balakr.…”

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confidence: 99%

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Chattopadhyay¹,

Das²,

Mandal³

et al. 2007

Oriental Pharmacy and Experimental Medicine

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SUMMARYThis study reports the analgesic, anti-inflammatory and membrane-stabilizing property of alcoholic extract of Ophiorrhiza nicobarica (ON), a wild herb, used as an anti-infective ethnomedicine of Nicobarese and Shompen tribes of Great Nicobar Island, India. We for the first time investigated the analgesic and antiinflammatory potential of this herb in acute, subacute and chronic model of inflammation in Swiss albino mice and Wistar albino rats, along with sheep RBC-induced sensitivity and membrane stabilization. The acetic acid induced writhing, tail flick and tail immersion tests are used as a model for evaluating analgesic activity; while the carrageenin-induced paw oedema was used as the model for acute inflammation, dextran-induced oedema as sub-acute and cotton-pellateinduced granuloma as chronic inflammatory model. The probable mode by which ON mediate its effect on inflammatory conditions was studied on sheep RBC-induced sensitivity and membrane stabilization. The in vitro results revealed that the ON extract possesses significant (P < 0.05) dose dependent analgesic and antiinflammatory activity at 200 and 300 mg/kg and its fractions at 50 mg/ kg, p.o. respectively, compared to the control groups. However, the extract failed to exhibit membrane-stabilizing property as it unable to reduce the level of haemolysis of RBC exposed to hypotonic solution. The acute toxicity studies of ON extract in rats and mice revealed that the extract was nontoxic even up to 3.0 g/kg body weight of the animals, with a high safety profile. We have isolated ursolic acid, β-sitosterol and harmaline respectively, from the bioactive part of the extract. The results indicated that the O. nicobarica is indeed beneficial in primary health care, and suggest that its anti-inflammatory activity may not be related to membrane-stabilization.

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Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract

Cited by 130 publications

References 14 publications

Antimicrobial and anti-inflammatory properties ofFuntumia elastica

Antimicrobial and anti-inflammatory properties ofFuntumia elastica

Antioxidant activity of phenolic fractions of Mallotus philippinensis bark extract

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

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