Antimicrobial and Anti-Prostate Cancer Activity of Turmeric (Curcuma longa L.) and Black Pepper (Piper nigrum L.) used in Typical Pakistani Cuisine

Irshad, Saba; Ashfaq, Ayesha; Muazzam, Ammara; Yasmeen, Abida

doi:10.17582/journal.pjz/2017.49.5.1665.1669

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…The aqueous, ethanol and methanol extracts of turmeric ( Curcuma longa ) presented an antiproliferative effect on PC-3 cells with respectively 34%, 55%, and 60% inhibition [134]. Zingiber officinale (ginger), whole extract (GE) has a high growth-inhibitory and death-inductory effects in a wide-spectrum of prostate cancer cells (IC 50 = 75–512 μg/mL), by impairing reproductive capacity, cell-cycle progression, mitochondrially mediated apoptosis, modulating cell-cycle/apoptosis regulatory molecules.…”

Section: Plant Extracts and Plant-derived Bioactives In Prostate Cmentioning

confidence: 99%

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

et al. 2019

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Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constituents possess promising chemopreventive properties. In this sense, the aim of the present review is to provide a detailed overview of the role of plant-derived phytochemicals in prostate cancers, including the contribution of plant extracts and its corresponding isolated compounds.

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Section: Plant Extracts and Plant-derived Bioactives In Prostate Cmentioning

confidence: 99%

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

et al. 2019

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“…Although spices have been widely used in rituals, and as flavorings and coloring agents since ancient times [9], recent literature has increasingly reported on the antibacterial activity of spices against common Gram-positive and Gram-negative bacteria responsible for human infectious diseases and food safety problems [10,11,12,13]. Examples of such spices are cinnamon, oregano, nutmeg, basil, pepper, thyme, clove, rosemary, ginger, cumin, etc.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Antibacterial Dietary Spices That Target Antibiotic-Resistant Bacteria

et al. 2019

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Although spice extracts are well known to exhibit antibacterial properties, there is lack of a comprehensive evaluation of the antibacterial effect of spices against antibiotic-resistant bacteria. In the present study, ethanolic extracts from a total of 67 spices were comprehensively investigated for their in vitro antibacterial activities by agar well diffusion against two common food-borne bacteria, Staphylococcus aureus and Salmonella enteritidis, with multi-drug resistance. Results showed that S. aureus was generally more sensitive to spice extracts than S. enteritidis. Of the 67 spice extracts, 38 exhibited antibacterial activity against drug-resistant S. aureus, while only four samples were effective on drug-resistant S. enteritidis. In addition, 11 spice extracts with inhibition zones greater than 15 mm were further verified for their broad-spectrum antibacterial properties using another 10 drug-resistant S. aureus strains. It was found that five spice extracts, including galangal, fructus galangae, cinnamon, yellow mustard seed, and rosemary, exhibited the highest antibacterial capacity. Further cytotoxicity of these 11 spices was determined and LC50 values were found to be more than 100 μg/mL except for galangal, rosemary, and sage, whose LC50 values were 9.32 ± 0.83, 19.77 ± 2.17, and 50.54 ± 2.57, respectively. Moreover, the antioxidant activities (ferric-reducing antioxidant power (FRAP) and trolox equivalent antioxidant capacity (TEAC) values) and total phenolic content (TPC) of spice extracts were determined to establish possible correlations with the antibacterial activity. Although the antibacterial effect was positively correlated with the antioxidant activities and TPC, the correlation was weak (r < 0.5), indicating that the antibacterial activity could also be attributed to other components besides antioxidant polyphenols in the tested spice extracts. In conclusion, dietary spices are good natural sources of antibacterial agents to fight against antibiotic-resistant bacteria, with potential applications as natural food preservatives and natural alternatives to antibiotics in animal feeding.

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“…The increasing microbial resistance to antibiotics has led to the search for new antibacterial agents from medicinal plants [2] and medicinal plants such as Piper guineense and Xylopia aethiopica , which are used in the treatment of bacterial infections in West African traditional medicine, could be good sources for these compounds. Based on numerous pharmacological studies, there is growing interest in medicinal plants as sources of antibacterial agents and adjuvants [3,4]. It has been established that plant-derived compounds and plant extracts are potential sources for new antibacterial drugs against multi-drug-resistant (MDR) pathogens [3,5].…”

Section: Introductionmentioning

confidence: 99%

“…Based on numerous pharmacological studies, there is growing interest in medicinal plants as sources of antibacterial agents and adjuvants [3,4]. It has been established that plant-derived compounds and plant extracts are potential sources for new antibacterial drugs against multi-drug-resistant (MDR) pathogens [3,5]. In many African countries, bacterial infections are among the main causes of diseases that affect the population and they often lead to life-threatening complications and can frequently result in death.…”

Section: Introductionmentioning

confidence: 99%

Alkaloid-Rich Crude Extracts, Fractions and Piperamide Alkaloids of Piper guineense Possess Promising Antibacterial Effects

et al. 2018

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Piper guineense is a food and medicinal plant commonly used to treat infectious diseases in West-African traditional medicine. In a bid to identify new antibacterial compounds due to bacterial resistance to antibiotics, twelve extracts of P. guineense fruits and leaves, obtained by sequential extraction, as well as the piperine and piperlongumine commercial compounds were evaluated for antibacterial activity against human pathogenic bacteria. HPLC-DAD and UHPLC/Q-TOF MS analysis were conducted to characterize and identify the compounds present in the extracts with promising antibacterial activity. The extracts, with the exception of the hot water decoctions and macerations, contained piperamide alkaloids as their main constituents. Piperine, dihydropiperine, piperylin, dihydropiperylin or piperlonguminine, dihydropiperlonguminine, wisanine, dihydrowisanine and derivatives of piperine and piperidine were identified in a hexane extract of the leaf. In addition, some new piperamide alkaloids were identified, such as a piperine and a piperidine alkaloid derivative and two unknown piperamide alkaloids. To the best of our knowledge, there are no piperamides reported in the literature with similar UVλ absorption maxima and masses. A piperamide alkaloid-rich hexane leaf extract recorded the lowest MIC of 19 µg/mL against Sarcina sp. and gave promising growth inhibitory effects against S. aureus and E. aerogenes as well, inhibiting the growth of both bacteria with a MIC of 78 µg/mL. Moreover, this is the first report of the antibacterial activity of P. guineense extracts against Sarcina sp. and E. aerogenes. Marked growth inhibition was also obtained for chloroform extracts of the leaves and fruits against P. aeruginosa with a MIC value of 78 µg/mL. Piperine and piperlongumine were active against E. aerogenes, S. aureus, E. coli, S. enterica, P. mirabilis and B. cereus with MIC values ranging from 39–1250 µg/mL. Notably, the water extracts, which were almost devoid of piperamide alkaloids, were not active against the bacterial strains. Our results demonstrate that P. guineense contains antibacterial alkaloids that could be relevant for the discovery of new natural antibiotics.

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Antimicrobial and Anti-Prostate Cancer Activity of Turmeric (Curcuma longa L.) and Black Pepper (Piper nigrum L.) used in Typical Pakistani Cuisine

Cited by 11 publications

References 11 publications

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

Discovery of Antibacterial Dietary Spices That Target Antibiotic-Resistant Bacteria

Alkaloid-Rich Crude Extracts, Fractions and Piperamide Alkaloids of Piper guineense Possess Promising Antibacterial Effects

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