Antimicrobial and antibiofilm activities of prenylated flavanones from Macaranga tanarius

Lee, Jin-Hyung; Kim, Yong‐Guy; Khadke, Sagar Kiran; Yamano, A.; Woo, Je‐Tae

doi:10.1016/j.phymed.2019.153033

Cited by 35 publications

(28 citation statements)

References 32 publications

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“…In a previous report, a methanolic extract of propolis from subtropical eastern Australia, enriched with NA and NC, did not inhibit Klebsiella pneumoniae or Candida albicans (Massaro et al, 2015). This does not agree with the findings of Lee et al (2019) and this is might be owing to the absence of NB. It has been reported that the flavonoids of OP and TP can interact specifically with the cell walls of bacteria, resulting in cell lysis and, eventually, bacterial death (Bryan, Redden, & Traba, 2016).…”

Section: Pharmacological Properties Of Macaranga‐type Pacific Propolicontrasting

confidence: 99%

“…coli (El‐Bassuony & AbouZid, 2010). Lee et al (2019) purified NA, NB, NC, and INB from M . tanarius and checked them against 14 different microbes, including bacteria and fungi, with 10 pathogenic strains.…”

Section: Pharmacological Properties Of Macaranga‐type Pacific Propolimentioning

confidence: 99%

“…Similarly, in another study, NB was shown to be nontoxic to C . elegans at concentrations up to 200 μg ml −1 (Lee et al, 2019). When the geranylated flavonoids, NA, NB, NC, INB, and GN, were applied to brine shrimps, an animal model often used to determine the cytotoxicity of natural compounds, they were also found to be nontoxic up to 50 μM concentrations (unpublished results).…”

Section: Pharmacological Properties Of Macaranga‐type Pacific Propolimentioning

confidence: 99%

“…Propolis has been effectively used for traditionally treating a variety of inflammatory diseases since the ancient Egyptian era (Maruta, 2013). Chen, Chien, et al (2018) first confirmed that TP extract can significantly decrease the expression of major inflammatory cytokines, including tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1 beta (IL- OP extract Antioxidant, anti-melanogenic, anticancer, longevity extension Kumazawa et al, 2008;Taira et al, 2016 TP extract Antioxidant, antimicrobial, antiinflammation, antidiabetic, Antifibrotic, cytotoxic, apoptosis induction Chen, Weng, et al, 2004;Chen et al, 2019;Chen, Chien, et al, 2018;Chen et al, 2008;Chen, Ye, et al, 2018;Hsieh et al, 2019;Huang et al, 2007;Lu et al, 2003Lu et al, , 2005Su et al, 2014 Nymphaeol-A Antioxidant, antimicrobial, antiinflammatory, anticancer, antidiabetic, anti-Alzheimer's, apoptosis induction Chen, Ye, et al, 2018;Kumazawa et al, 2004Kumazawa et al, , 2007Lee et al, 2019;Massaro et al, 2015;Nguyen, Yoshimura, Kumazawa, Tawata, & Maruta, 2017;Pai et al, 2018;Raghukumar et al, 2010;Shahinozzaman et al, 2018 Nymphaeol-B Antioxidant, antimicrobial, antiinflammatory, anticancer, antidiabetic, anti-Alzheimer's, antiaging Chen, Ye, et al, 2018;Kumazawa et al, 2004Kumazawa et al, , 2007Lee et al, 2019;Raghukumar et al, 2010;Shahinozzaman et al, 2018;Taira et al, 2016 Nymphaeol-C Antioxidant, antimicrobial, antiinflammatory, anticancer, antidiabetic, anti-Alzheimer's, Antifibrotic, Neuroprotective, apoptosis induction Chen, Ye, et al, 2018;…”

Section: Anti-inflammatory Actionmentioning

confidence: 99%

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Chemical composition and pharmacological properties of Macaranga‐type Pacific propolis: A review

Shahinozzaman

Obanda

Tawata

2020

Phytotherapy Research

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Propolis, a resinous substance, is collected from plants and processed by honeybees to seal holes and cracks in beehives, protecting them from microbial infection. Based on the plant source and geographical location, propolis is categorized into seven groups. Of these, Pacific propolis, found in the Pacific islands, originates from Macaranga spp. and is, therefore, known as Macaranga‐type Pacific propolis. Okinawa propolis and Taiwanese propolis, which are both Macaranga‐type propolis, are rich in prenylated flavonoids from the same botanical source, Macaranga tanarius, and are used locally as traditional remedies. They are reported to have a wide range of pharmacological benefits, including antioxidant, anti‐inflammation, antimicrobial, anticancer, antidiabetic, anti‐Alzheimer's, anti‐melanogenic, and longevity‐extending effects. However, not much is known about their mode of action, and recently, the extract of Okinawa propolis and its major prenylated flavonoids were found to selectively inhibit the oncogenic kinase, p21‐activated kinase 1 (PAK1). PAK1 enables cross‐talking among several signaling pathways, causing many diseases/disorders. The existing results reviewed here support the use of Macaranga‐type Pacific propolis for the effective development of safe herbal drugs and functional foods. Furthermore, its mode of action by modulating PAK1 can be explored, and the geographical and seasonal effects on its chemistry and biology, and its pharmacokinetics and toxicology should be studied as well.

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Section: Pharmacological Properties Of Macaranga‐type Pacific Propolicontrasting

confidence: 99%

Section: Pharmacological Properties Of Macaranga‐type Pacific Propolimentioning

confidence: 99%

Section: Pharmacological Properties Of Macaranga‐type Pacific Propolimentioning

confidence: 99%

Section: Anti-inflammatory Actionmentioning

confidence: 99%

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Chemical composition and pharmacological properties of Macaranga‐type Pacific propolis: A review

Shahinozzaman

Obanda

Tawata

2020

Phytotherapy Research

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“…46 Lee et al showed that, propolin D obtained from M. tanarius at 5 to10 μg/ml significantly inhibited biofilm formation by three S. aureus strains, and S. epidermidis strain, with an MIC of 10 μg/ml. 47 Furthermore, the low antibacterial activity observed in some extracts would be due to the presence within the tested bacteria of efflux systems which are responsible, when they are over-expressed, for the phenomenon of multi-resistance. 48 Efflux pumps have been shown to decrease the intracellular concentration of antibiotics and consequently their activity.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activities and Phytochemical Screening of Crude Extracts from Kenyan Macaranga Species Towards MDR Phenotypes Expressing Efflux Pumps

Ibrahim¹,

Omosa²,

Nchiozem-Ngnitedem³

et al. 2021

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Introduction: Macaranga species are traditionally used for the treatment and management of coughing, fungal infection, and wounds. In this study, the phytochemical screening and antibacterial activities of nine crude extracts from Macaranga conglomerata, Macaranga kilimandscharica and Macaranga capensis were determined against 13 bacterial strains expressing multi-drug resistance (MDR) phenotypes. Methods: Phytochemical screening of the extracts were carried out according to the standard methods, while the iodonitrotetrazolium chloride (INT) colorimetric assay was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the plants extracts. Results: Flavonoids, terpenoids, saponins and coumarins were the major secondary metabolites found in all the plant extracts. The results of antibacterial studies revealed that all the plant extracts displayed good activities with MIC values ranging from 4 -128 µg/mL against the tested micro-organisms. Most of the extracts exhibited a bactericidal effect against E. coli, E. aerogenes, K. pneumoniae, P. stuartii, P. aeruginosa, and S. aureus with MBC/MIC ratio ≤ 4. In the presence of efflux pump inhibitor (PaβN), the inhibition potency of all the crude extracts against the tested bacterial strains were substantially enhanced. It is worth noting that the activities of MKL, MCL, and MCR towards P. stuartii (NEA16), E. aerogenes (ATCC13048), and K. pneumoniae (KP55), respectively were improved by more than 8-fold in the presence of PAβN. Conclusion: The findings of this study indicated the possibility of using all the tested plant extracts as a source of therapeutic agents in the fight against multi-drug resistant bacteria.

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Macaranga tanarius (L.) Müll.Arg. Euphorbiaceae

Mustaqim¹

2020

Ethnobotany of Mountain Regions

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Local NamesIndonesia: binunga (Sangir in Sulawesi); dahan (Alf. Minahasa); hanuwa (Ambon and Seram); hinan, lama (Ambon); karahan, tutup, tutup ancur, waru laut (Javanese); kayu mata putih (Atinggola in Gorontalo); kemahang putih (Bengkalis in Riau); lapi (Kolaka Timur and Buton in Sulawesi); mara (Sundanese); madau (Lampung); mapu (Batak); mombeti (Sigi in Sulawesi); ndenu (East Luwu in Sulawesi); rebak (Manggarai in Flores); same (Lako Akediri in Halmahera); sapat (Serampas in Jambi); seribu guna (Pidie in Aceh); surok (Krui in Lampung); totop lakèk (Madura); tubi tahak (Tetun in West Timor); tutup (Kerinci in Central Sumatra); umera (Wungkolo in Wawonii, Southeast Sulawesi). Malaysia: inchong, jebat musang, kundoh, mahang puteh, tampu, tampu hitam, tampu puteh; daun bayangan (Murut, Sabah); mahang putih (Ulu, Sarawak).

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Antimicrobial and antibiofilm activities of prenylated flavanones from Macaranga tanarius

Cited by 35 publications

References 32 publications

Chemical composition and pharmacological properties of Macaranga‐type Pacific propolis: A review

Chemical composition and pharmacological properties of Macaranga‐type Pacific propolis: A review

Antibacterial Activities and Phytochemical Screening of Crude Extracts from Kenyan Macaranga Species Towards MDR Phenotypes Expressing Efflux Pumps

Macaranga tanarius (L.) Müll.Arg. Euphorbiaceae

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