Antimicrobial and antifungal activity of crude extracts and isolated saponins from Astragalus verrucosus

Anti-candidal activity of Astragalus verus in the in vitro and in vivo guinea pig models of cutaneous and systemic candidiasis

“…In mice infected with coxsackie B-3 virus, Astragalus inhibited viral replication in the myocardial tissue while improving abnormal myocardial electric activity (Lee et al, 2007). The antimicrobial and antifungal properties of several crude extracts from different parts of other Astragalus species have been reported (Bisignano et al, 1994;El Sebakhy et al, 1994;Pistelli et al, 2002). The aqueous extract of Av showed maximum antifungal activity in the present study.…”

“…The aqueous extract of Av showed maximum antifungal activity in the present study. Antimycotic activity of aerial parts of Astragalus verrucosus was observed on more polar extracts as well (Pistelli et al, 2002). The aqueous extract of Av at dose 40% showed an acceptable efficacy in comparison to licensed compound KTZ and CFUs of skin and internal organs were significantly reduced and continued to decline in contrast to the progressive infection observed in the untreated animals throughout the observation period.…”

“…Further studies are required to find the active compound in the aqueous extract of Av that demonstrates antifungal or possibly immune-modulating activities. In this sense, the active compounds including of pure saponins and astraverrucins I-VI derived from Astragalus verrucosus, antimicrobial isoflavans, astragaluquinone, 8-methoxyvestitol and 7-hydroxy-2′,3′,4′-trimethoxyisoflavan were isolated from roots of Astragalus alexandrinus and A. trigonus showed an appreciable antimicrobial activity (El Sebakhy et al, 1994;Pistelli et al, 2002).…”

Evaluation of Antibacterial and Antitumor Activities of Some Turkish Endemic Plants

“…A. gymnolobus extracts were also effective only on Aeromonas hydrophila among tested five different fish pathogens [24]. The moderate antibacterial activities of some members of Astragalus species (A. siculus, A. gummifer, A. membranaceus, A. malanophrurius and A. verrucosus) were recorded against Grampositive and Gram-negative bacteria [10,25]. A. siculus showed antibacterial activity against S. aureus, S. epidermidis, Streptococcus faecalis, [25].…”

“…Astragalus species have been used traditionally to raise immune resistance, improve physical endurance and lower blood pressure [4]. Astragalus species have anti-inflammatory, analgesic, hypotensive, sedative, cardiotonic, hepatoprotective, antioxidative, antiviral and immunostimulant properties [7][8][9][10][11].…”