Antimicrobial and antimalarial activity of Cussonia species (Araliaceae)

Villiers, B.J. De; Vuuren, Sandy van; Zyl, Robyn L. van; Wyk, B.‐E. Van

doi:10.1016/j.jep.2010.02.014

Cited by 35 publications

(50 citation statements)

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“…Literature data on the biological activity and phytochemical constituents of B. mollis is limited. The genus Cussonia has been extensively studied for its antiplasmodial properties, and the polar bark extracts of C. spicata were reported to have a relatively weak activity (De Villiers et al, 2010). Results obtained in this study are consistent with those reported for other members of the same family, when extracted with non-polar solvent (Clarkson et al, 2004).…”

Section: Resultssupporting

confidence: 88%

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Bapela

Meyer

Kaiser

2014

Journal of Ethnopharmacology

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Abstract:Ethnopharmacological relevance: The investigated plant species are traditionally used by Venda people of South Africa, in the treatment of malaria and associated symptoms.Aim of the study: To evaluate the in vitro antiplasmodial efficacy and cytotoxic properties of indigenous medicinal plants used by Venda people against malaria. Materials and methods:In vitro antiplasmodial activity and cytotoxic properties were evaluated on twenty indigenous plant species. Ground plant material was extracted in dichloromethane: 50% methanol (1:1). Antiplasmodial activity was evaluated against the chloroquine-sensitive strain of Plasmodium falciparum (NF54). The cytotoxicity of the plant extracts were assessed against mammalian L-6 rat skeletal myoblast cells. The selectivity index (SI) values were then calculated.Results: Of the 43 plant extracts evaluated, 10 exhibited pronounced antiplasmodial activity (IC 50 ≤ 5μg/ml) with good therapeutic indices (SI ≥ 10). Lipophilic plant extracts were relatively more potent than polar extracts. Tabernaemontana elegans Stapf. (Apocynaceae) and Vangueria infausta Burch. subsp. infausta (Rubiaceae) extracts displayed significant antiplasmodial activity (IC 50 < 2 μg/ml). Conclusion:Findings of this study partly support the ethnomedical use of the investigated plant species by Venda people as antimalarial remedies. The study also highlights some of the knowledge gaps that require further phytochemical studies on the specified plant species.

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Section: Resultssupporting

confidence: 88%

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Bapela

Meyer

Kaiser

2014

Journal of Ethnopharmacology

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“…The extracts demonstrated their highest activity against Gram-negative standard strains of bacteria. Similar results were obtained by De Villiers et al (2010). In their investigations, methanolic extracts from the leaves of Cussonia sp.…”

Section: Discussionsupporting

confidence: 92%

The production of ginsenosides in hairy root cultures of American Ginseng, Panax quinquefolium L. and their antimicrobial activity

Kochan

Wasiela

Sienkiewicz

2012

In Vitro Cell.Dev.Biol.-Plant

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Panax quinquefolium, American ginseng, is valued for its triterpene saponins, known as ginsenosides. These constituents possess a number of pharmacological properties and hairy root cultures can synthesize similar saponins to those of field-cultivated roots. The antibacterial activity of extracts from three hairy root clones of P. quinquefolium L. was tested against a range of standard bacterial and yeast strains. The agar diffusion method was used to evaluate inhibition of microbial growth at various extract concentrations. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains. Susceptibility testing to antibiotics was also tested using the disk diffusion method. The minimal inhibitory concentration values of the extracts, obtained by agar diffusion, ranged from 0.8 to 1.4 mg/ml. The results showed that extracts from hairy root cultures inhibited the growth of bacteria and yeast strains and suggest that they may be useful in the treatment of infections caused by pathogenic microorganisms.

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“…viii) Sores are treated using ten species, these include Aster sp., Chenopodium sp., Cussonia paniculata, E. clavarioides (for cancerous sores), and Hypoxis argentea (sores on horses). Cussonia paniculata is widely used in traditional medicine as an analgesic, anti-inflammatory, and for treating malaria, mental illness, and wounds (Adedapo et al, 2008;De Villiers et al 2010). …”

Section: Plants Used For Other Skin Disordersmentioning

confidence: 99%

A Review of Medicinal Plants Used by the Basotho for Treatment of Skin Disorders: Their Phytochemical, Antimicrobial, and Anti-Inflammatory Potential

Moteetee¹,

Kose²

2017

Afr J Tradit Complement Altern Med

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Background: While the incidence of skin diseases is high in developing countries, they are not regarded as priority due to low mortality rates, however, they are a major concern due to their co-occurrence with HIV/AIDS. Due to lack of accessibility to healthcare facilities and unaffordability of conventional medicines, many people in rural areas resort to medicinal plants. The aim of the study is to document the plants used for treating skin afflictions by the Basotho people residing in Lesotho and the Free State Province of South Africa. Materials and Methods: A comprehensive survey of existing ethnobotanical literature including numerous books was carried out. Electronic databases such as Google Scholar, PubMed, and ScienceDirect were also used to obtain information on the antiinflammatory, antimicrobial, and phytochemical activities of the medicinal plants. Results and discussion: 57 plant species are utilised for the treatment of various skin ailments with a majority of them used for wounds (26 species) and venereal sores (19 species). The plants are distributed in 39 families with the Asteraceae being the most represented with seven species, followed by Solanaceae and Asphodelaceae with four species each. 38 species have previously been evaluated for their phytochemical properties, 40 for their anti-microbial potential, while 29 have been assessed for their antiinflammatory activity. Of the 57, 13 species have not been evaluated for any of the three categories. Conclusion: Many of the plants have been shown to have anti-microbial, anti-inflammatory, and phytochemical properties, which then validates their traditional use.

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Antimicrobial and antimalarial activity of Cussonia species (Araliaceae)

Cited by 35 publications

References 50 publications

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

The production of ginsenosides in hairy root cultures of American Ginseng, Panax quinquefolium L. and their antimicrobial activity

A Review of Medicinal Plants Used by the Basotho for Treatment of Skin Disorders: Their Phytochemical, Antimicrobial, and Anti-Inflammatory Potential

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