Antimicrobial and antioxidant activities of a new benzamide from endophytic<i>Streptomyces</i>sp. YIM 67086

Yang, Xue‐Qiong; Peng, Tianfeng; Yang, Ya‐Bin; Li, Wei; Xiong, Jie; Zhao, Li‐Xing; Ding, Zhong‐Tao

doi:10.1080/14786419.2014.945174

Cited by 39 publications

(11 citation statements)

References 5 publications

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“…Streptomyces species are gram-positive filamentous bacteria, which can grow in various ecosystems, including sea sponges (Han et al 2009), soil (Nguyen et al 2015), animal faeces (Wang et al 2014) and termites (Zhang et al 2013). They are able to produce both secondary metabolites (Wang et al 2013;Zhang et al 2013) and hydrolytic enzymes (Karthik et al 2015;Nagpure and Gupta 2013) or potentially novel anti-microbial compounds (Yang et al 2015;Yekkour et al 2015;Shakeel et al 2018). Some compounds have been shown to inhibit spore germination (Wang et al 2013;Zhang et al 2013) and mycelial growth of spoilage fungi (Nguyen et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of metabolites of a Streptomyces strain (AS1) to control growth and mycotoxin production by Penicillium verrucosum, Fusarium verticillioides and Aspergillus fumigatus in culture

et al. 2020

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The objectives of this study were to determine the efficacy of metabolites of a Streptomyces strain AS1 on (a) spore germination, (b) mycelial growth, (c) control of mycotoxins produced by Penicillium verrucosum (ochratoxin A, OTA), Fusarium verticillioides (fumonisins, FUMs) and Aspergillus fumigatus (gliotoxin) and (d) identify the predominant metabolites involved in control. Initial screening showed that the Streptomyces AS1 strain was able to inhibit the mycelial growth of the three species at a distance, due to the release of secondary metabolites. A macroscopic screening system showed that the overall Index of Dominance against all three toxigenic fungi was inhibition at a distance. Subsequent studies showed that the metabolite mixture from the Streptomyces AS1 strain was very effective at inhibiting conidial germination of P. verrucosum, but less so against conidia of A. fumigatus and F. verticillioides. The efficacy was confirmed in studies on a conducive semi-solid YES medium in BioScreen C assays. Using the BioScreen C and the criteria of Time to Detection (TTD) at an OD = 0.1 showed good efficacy against P. verrucosum when treated with the Streptomyces AS1 extract at 0.95 and 0.99 water activity (a w) when compared to the other two species tested, indicating good efficacy. The effective dose for 50% control of growth (ED 50) at 0.95 and 0.99 a w were approx. 0.005 ng/ml and 0.15 μg/ml, respectively, with the minimum inhibitory concentration (MIC) at both a w levels requiring > 40 μg/ml. In addition, OTA production was completely inhibited by 2.5 μg/ml AS1 extract at both a w levels in the in vitro assays. Ten metabolites were identified with four of these being predominant in concentrations > 2 μg/g dry weight biomass. These were identified as valinomycin, cyclo(L-Pro-L-Tyr), cyclo(L-Pro-L-Val) and brevianamide F.

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Section: Introductionmentioning

confidence: 99%

Efficacy of metabolites of a Streptomyces strain (AS1) to control growth and mycotoxin production by Penicillium verrucosum, Fusarium verticillioides and Aspergillus fumigatus in culture

et al. 2020

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“…Microorganisms can also induce the production or accumulation of plant metabolites that can improve tolerance of plants to stresses [4][5][6]. Some studies have shown that microorganisms can mediate the interaction between host plants and pathogens by producing antimicrobial compounds and antioxidants or inducing systemic resistance [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Role of Endophytic Fungi in Gentiana scabra bge. by Cross-Growth Period Inoculation

Wang

et al. 2018

Indian J Microbiol

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Bge. (gentian) is a Chinese medicinal plant. Endophytic fungi from the roots of gentian were isolated and cross-growth period inoculation was performed to study the roles of three spp. strains (F1, F2, and F9) in their original host plant. In treatments inoculated with F1, F2, and F9, gentiopicroside content increased 33.6, 23.7 and 13% than that in the control. Strains F1, F2, and F9 could also improve polysaccharide content by more than 6.6, 18.7 and 30% compared to the control. The incidence of spot blight in gentian inoculated with F1, F2, and F9 decreased by 31.2, 26.7 and 8.5%. Inconsistent changes in the activity of the three enzymes (superoxide dismutase, catalase and peroxidase) were observed when the plants were attacked by pathogens or inoculated with fungi. High enzymatic activity did not reflect mild disease. Cross-growth period inoculation, which takes into account the original living environment (gentian plant as "substrate" and different microorganisms as symbionts) of endophytic fungi, provides a new idea for studying effects of endophytes on their original hosts. This is the first research about the role of endophytic fungi in bge. in vivo.

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“…The secondary metabolites (1)(2)(3)(4)(5)(6) of Streptomyces played an important role in natural products which have attracted great attention of researchers due to their complicated structures and potential biological activities. Previously reported chemical investigations of the genus Streptomyces include the antifungal hygrolidin (7), cytotoxic elmonin (8), antibacterial angumycinone C (9) and antitumour streptonoate (10).…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites from Streptomyces sp CSDX076 for the First Time

Qian¹,

Shao²,

Yz³

et al. 2016

West Indian Med J

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Objective: To investigate the secondary metabolites from the cultures of Streptomyces sp CSDX076. Methods: The compounds were isolated using column chromatography and RP-18 mediumpressure liquid chromatography. Their structures were elucidated by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopic methods in combination with mass spectrometry experiments. Results: Four compounds were isolated from the cultures of Streptomyces sp CSDX076 and identified as aurantiamide benzoate, deoxytryptoquivaline, 2-acetyl-3,5-dihydroxyl-benzene acetic acid, and 2-acetyl-3,5-dihydroxyl-benzene ester. Conclusion: It was the first time that the four isolated compounds were obtained from the Streptomyces genus.

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Antimicrobial and antioxidant activities of a new benzamide from endophyticStreptomycessp. YIM 67086

Cited by 39 publications

References 5 publications

Efficacy of metabolites of a Streptomyces strain (AS1) to control growth and mycotoxin production by Penicillium verrucosum, Fusarium verticillioides and Aspergillus fumigatus in culture

Efficacy of metabolites of a Streptomyces strain (AS1) to control growth and mycotoxin production by Penicillium verrucosum, Fusarium verticillioides and Aspergillus fumigatus in culture

Investigating the Role of Endophytic Fungi in Gentiana scabra bge. by Cross-Growth Period Inoculation

Secondary Metabolites from Streptomyces sp CSDX076 for the First Time

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