Antimicrobial and Antioxidant Activity Analysis of Some Medicinal Plants of Bangladesh

Solaiman, Abul Hasnat Muhammad; Ahmmed, Abu Noman Faruq; Hasanuzzaman, Mirza; Sultana, Nazia; Sarke, Brazendranath; Rahman, Raquibur; Shahjahan, Mohammad; Nishizawa, Takashi

doi:10.15406/apar.2015.02.00057

Cited by 2 publications

(3 citation statements)

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“…A total of 115 phytocompounds were retrieved from Dr. Duke’s phytochemical and ethnobotanical databases ( https://phytochem.nal.usda.gov/phytochem/search/list ) and the natural product activity and species source database ( https://bidd.group/NPASS/ ), which are the components of 14 indigenous medicinal plants of Bangladesh. These plants have several antimicrobial activities against S. aureus [ 30 , 31 ].…”

Section: Methodsmentioning

confidence: 99%

Developing phytocompound-based new drugs against multi-drug-resistant Staphylococcus aureus

Shuvo,

Halder,

Alam

et al. 2024

R. Soc. Open Sci.

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Staphylococcus aureus , a prevalent component of the human microbiota, is associated with skin infections to life-threatening diseases, presenting challenges in treatment options and necessitating the development of effective treatments. This study integrated computational and in vitro approaches to identify promising phytocompounds with therapeutic potential. Staphopain B emerged as a target protein for its role in immune evasion, exhibiting stability during molecular dynamic simulation (MDS) with a root mean square deviation value of 2.376 Å. Screening 115 phytocompounds with antibacterial properties from the PubChem database identified 12 with drug-like properties, nine of which showed superior binding affinity to Staphopain B compared to a commercial antibiotic, doxycycline (−7.8 kcal mol −1 ). Notably, epoxyazadiradione and nimbolide displayed higher estimated free energy of binding scores (−7.91 and −7.93 kcal mol −1 , respectively), indicating strong protein–ligand interactions. The root mean square fluctuation values for epoxyazadiradione and nimbolide were 1.097 and 1.034 Å, respectively, which was confirmed through MDS. Crude ethanolic extracts (100% and 70%) of neem ( Azadirachta indica ) leaves demonstrated narrow inhibition against the bacteria in comparison to doxycycline in the disc-diffusion assay. This study underscores the potential of phytocompounds as therapeutic agents against S. aureus ; however, further in vitro experiments and testing of the phytocompounds in vivo are required.

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Section: Methodsmentioning

confidence: 99%

Developing phytocompound-based new drugs against multi-drug-resistant Staphylococcus aureus

Shuvo,

Halder,

Alam

et al. 2024

R. Soc. Open Sci.

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show abstract

“…In an earlier study, various solvent extracts of flower of C. guianensis was found to inhibit fungi namely Candida albicans, Aspergillus niger, and Saccharomyces cerevisiae with maximum activity displayed by ethyl acetate extract. [48] In another study, Shivashankar et al [30] observed the inhibition of C. albicans by hydromethanolic extract of bark of C. guianensis. The study of Al-Dhabi et al [49] revealed the inhibitory activity of fruit extract of C. guianensis against C. albicans and Malassezia pachydermatis.…”

Section: Antifungal Activity Of Leaf and Flower Extractmentioning

confidence: 99%

“…It is evident from the result that the leaf and flower extracts of C. guianensis possess hydrogen donating ability, and therefore, these extracts can serve as free radical scavengers, acting possibly as primary antioxidants. In similar studies, various parts such as flower, [31,48] bark, [30] and leaf [41] of C. guianensis were shown to exhibit scavenging of DPPH radicals.…”

Section: Dpph Free Radical Scavenging Activity Of Leaf and Flower Extmentioning

confidence: 99%

Untitled

Kekuda

2017

IJGP

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Objectives: The objective of the present study was carried out to investigate antimicrobial, radical scavenging, and insecticidal activity of leaf and flower of Couroupita guianensis Aubl. (Lecythidaceae). Methods: Extraction of leaf and flower was carried out by maceration process using methanol. Antibacterial and antifungal activity of extracts was carried out by agar well-diffusion method and poisoned food technique, respectively. Radical scavenging activity of extracts was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical scavenging assays. Insecticidal activity of extracts was evaluated in terms of larvicidal and pupicidal effects against Aedes aegypti. Results: Leaf extract displayed marked antibacterial activity when compared to flower extract. Highest and least inhibitory activity of extracts was observed against Staphylococcus epidermidis and Escherichia coli, respectively. Both extracts displayed antifungal activity with highest activity exhibited by leaf extract. Highest and least susceptibility were shown by Curvularia sp. and Fusarium sp., respectively. Both extracts scavenged DPPH and ABTS radicals dose dependently. Leaf extract (IC 50 = 19.61 µg/ml) caused marked DPPH radical scavenging potential than flower extract ((IC 50 = 257.13 µg/ml). IC 50 value of ABTS radical inhibition of leaf and flower extract was found to be 7.63 and 53.34 µg/ml, respectively. Larvicidal and pupicidal activity by extracts was concentration dependent. The susceptibility of larvae and pupae to extract was in the order: 2 nd instar larvae > 4 th instar larvae > pupae. Leaf extract displayed marked insecticidal activity when compared to flower extract as revealed by lower LC 50 values. Conclusion: Overall, leaf extract exhibited marked bioactivities than flower extract. The plant can be used to treat microbial infections and oxidative damage and to manage fungal diseases. The plant can be used against mosquito vectors which transmit arboviral diseases.

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Antimicrobial and Antioxidant Activity Analysis of Some Medicinal Plants of Bangladesh

Cited by 2 publications

References 29 publications

Developing phytocompound-based new drugs against multi-drug-resistant Staphylococcus aureus

Developing phytocompound-based new drugs against multi-drug-resistant Staphylococcus aureus

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