Antimicrobial and antioxidant activity of phenolic extracts from walnut (Juglans regia L.) green husk by using pressure-driven membrane process

Arslan, Hüdaverdi; Koc, Eda Ondul; Özay, Yasin; Canlı, Oltan; Özdemir, Sadin; Tollu, Gülşah; Dizge, Nadir

doi:10.1007/s13197-022-05588-w

Cited by 17 publications

(6 citation statements)

References 38 publications

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“…Rahimi‐Panah et al. (2010) studied the optimum condition for phenol compound extraction from walnuts green peel and stated that an increase in the extraction time caused an increase in the concentration of extracted phenol compound while increasing in the percentage of ethanol showed a reverse effect. In this context, based on their findings, by decreasing methanol concentration from 100% to 60%, the amount of extracted phenolic compounds was increased.…”

Section: Resultsmentioning

confidence: 99%

Extraction of phenol compound from Mentha piperita by ultrasonic waves based on a response surface methodology

Roshanpour

Tavakoli

Beigmohammadi

et al. 2021

Food Science & Nutrition

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In this study, optimization of the extraction of phenol compounds from Mentha piperita using ultrasonic waves with response surface methodology (RSM) was assessed. In this regard, a central composite design with three independent variables of time (5, 27.5, and 50 min), temperature (25, 45, and 65°C), and concentrations of ethanol in the water–ethanol solution (0%, 50%, and 100%) was used. Besides, the antioxidant activity tests (DPPH radical scavenging assay, ferric reducing antioxidant power [FRAP], and oxidative stability indexes [OSI]) were examined. Significant effects of independent variables on the extraction of phenol compound, DPPH radical scavenging power, and OSI of M. piperita extract, with the regression coefficients of 0.89, 0.92, and 0.94, respectively, were noted. However, no significant difference in terms of the FRAP among different treatments was noted. Also, the best antioxidant activity of M . piperita was obtained by using the ultrasonic wave for 50 min at 65°C and 59.6% v/v ethanol/water solution. While the findings of RSM confirmed the experimental results, due to the favored properties of M . piperita extract by the proposed method, further research to investigate possible applications in the food industry is recommended.

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Section: Resultsmentioning

confidence: 99%

Extraction of phenol compound from Mentha piperita by ultrasonic waves based on a response surface methodology

Roshanpour

Tavakoli

Beigmohammadi

et al. 2021

Food Science & Nutrition

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“…In general, a high concentration of polyphenols will induce DNA damage; however, a low concentration tends to decrease DNA damage [38]. Phenols extracted from WGH demonstrated notable DNA nuclease activity on pBR322 DNA, with concentrated extracts completely degrading DNA [39]. These observations suggest that WGHa inhibits the synthesis of bacterial nucleic acids or damages bacteria DNA, thereby suppressing bacterial proliferation.…”

Section: Cellular Metabolic Vitalitymentioning

confidence: 96%

Antimicrobial Activity and Mechanisms of Walnut Green Husk Extract

Wang,

Li,

et al. 2023

Molecules

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Walnut green husks (WGHs), by-products of walnut production, are believed to possess antimicrobial properties, making them a potential alternative to antibiotics. In this study, the antibacterial activities of three extracts, derived from WGH, against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli were investigated, and the antibacterial mechanisms of an anhydrous ethanol extract of WGH (WGHa) were examined. The results showed that WGHa exhibited inhibitory effects on all tested bacteria. The ultrahigh-performance liquid chromatography–tandem mass spectrometry analysis revealed that the major active compounds present in WGHa were terpenoids, phenols, and flavonoids. Treatment with WGHa resulted in the leakage of intracellular ions and alkaline phosphatase; a reduction in intracellular ATP content, ATPase activity, and nucleic acid content; as well as cellular metabolic viability. The transmission electron microscopy images showed varying degrees of cell deformation and membrane damage following WGHa treatment. The transcriptome sequencing and differentially expressed gene enrichment analyses revealed an up-regulation in pathways associated with RNA degradation, translation, protein export, and oxidative phosphorylation. Conversely, pathways involved in cell movement and localization, as well as cell wall organization and carbohydrate transport, were found to be down-regulated. These findings suggest that WGHa alters cell membrane permeability and causes damage to the cell wall. Additionally, WGHa interferes with cellular energy metabolism, compromises RNA integrity, and induces DNA replication stress, consequently inhibiting the normal growth and proliferation of bacteria. These findings unveiled the antimicrobial mechanisms of WGHa, highlighting its potential application as an antibiotic alternative.

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“…The leaves are traditionally used to treat sinusitis and stomach aches and are also used throughout the world as an antibacterial, anthelmintic, antidiarrheal, hypoglycemic, tonic, and depurative medicine [ 45 , 46 ]. In Turkish traditional medicine, fresh leaves are applied to the naked body or the forehead to reduce fever or to swollen joints to treat rheumatic agony [ 47 ]. The wood is durable and perfect for furniture and contains essential oils for aromatic essence.…”

Section: Traditional and Ethnobotanical Usesmentioning

confidence: 99%

Juglans regia Linn.: A Natural Repository of Vital Phytochemical and Pharmacological Compounds

Bhat

Shakeel

Rafiq

et al. 2023

Life

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Juglans regia Linn. is a valuable medicinal plant that possesses the therapeutic potential to treat a wide range of diseases in humans. It has been known to have significant nutritional and curative properties since ancient times, and almost all parts of this plant have been utilized to cure numerous fungal and bacterial disorders. The separation and identification of the active ingredients in J. regia as well as the testing of those active compounds for pharmacological properties are currently of great interest. Recently, the naphthoquinones extracted from walnut have been observed to inhibit the enzymes essential for viral protein synthesis in the SARS-CoV-2. Anticancer characteristics have been observed in the synthetic triazole analogue derivatives of juglone, and the unique modifications in the parent derivative of juglone have paved the way for further synthetic research in this area. Though there are some research articles available on the pharmacological importance of J. regia, a comprehensive review article to summarize these findings is still required. The current review, therefore, abridges the most recent scientific findings about antimicrobial, antioxidant, anti-fungal, and anticancer properties of various discovered and separated chemical compounds from different solvents and different parts of J. regia.

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Antimicrobial and antioxidant activity of phenolic extracts from walnut (Juglans regia L.) green husk by using pressure-driven membrane process

Cited by 17 publications

References 38 publications

Extraction of phenol compound from Mentha piperita by ultrasonic waves based on a response surface methodology

Extraction of phenol compound from Mentha piperita by ultrasonic waves based on a response surface methodology

Antimicrobial Activity and Mechanisms of Walnut Green Husk Extract

Juglans regia Linn.: A Natural Repository of Vital Phytochemical and Pharmacological Compounds

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