Antimicrobial and antioxidant phytochemicals in leaf extracts ofBergenia ligulata: a Himalayan herb of medicinal value

Abstract

Phenolic and flavonoid contents in leaf extracts of Bergenia ligulata have been analysed for their contribution in antimicrobial and antioxidant activities. The extracts were prepared in three solvents (separately) following maceration and soxhelt methods. The antimicrobial activity was tested using disc diffusion assay against a range of microorganisms along with the determination of minimum inhibitory concentration (MIC), while the antioxidant activity was tested following DPPH assay. Leaf extracts exhibited antimicrobial activity against all the three groups of microorganisms; results coincided with respective MIC. In general, the methanol extracts prepared through maceration favoured the determination of antimicrobial and antioxidant activities. Maximum values for phenolic and flavonoid contents were obtained in macerated methanol and ethyl acetate extracts, respectively. The statistical correlations exhibited the extent of the contribution of phenolic and flavonoid contents in antimicrobial and antioxidant activities and also indicated the involvement of other plant metabolites.

Phytochemical Screening and in Vitro Antimicrobial and Antifungal Activity of Bergenia Ligulata (Wall.) Leaves Extracts

“…The circumstance that the various microbial isolates subjected to the extract of Bergenia ligulata were susceptible shows that the leaves of this plant have antimicrobial potency. The results were approved with the work of [19], who reported that the leave extract of Bergenia ligulata has antimicrobial and antioxidant potential against some selected range pathogens and infectious diseases. The results obtained show that the ethanolic extracts possess maximum potential against the extract on all microorganisms tested than the aqueous extracts.…”

Antioxidant, antimicrobial activity and bioactive compounds of Bergenia ciliata Sternb.: A valuable medicinal herb of Sikkim Himalaya

“…Among all, three main compounds viz., bergenin catechin and gallic acid are the most sought after compounds of the plant species 30 . During the past years, efforts have been made for identification and quantification of the major bioactive compounds from Bergenia spp 5, 28, 30, 31, 32. However, till date, B. ciliata plant of the Sikkim Himalaya has never been analyzed for secondary metabolites.…”

Biological and Pharmacological Activity of Plant Natural Compounds II

“…Citronellol (3,7-dimethyl-6-octen-1-ol) is a linear monoterpene alcohol naturally found in about 70 essential oils, with abundance in Cymbopogon nardus (L.) and citrus oil [124,125]. Cymbopogon nardus was previously used in Chinese medicine to treat rheumatism, fever, and digestive problems [126].…”

“…The constituents have been categorized into polyphenols, flavonoids, quinones, sterols, terpenes, tannins, lactones, and others [16,26,[64][65][66][67]. The major bioactive compounds are bergenin ( 1), (+)-catechin (2), gallic acid (3), β-sitosterol (4), catechin-7-O-β-d-glucoside ( 5), (+)-afzelechin (6), arbutin (10),4-O-galloylbergenin (12), 11-O-galloylbergenin (13), caffeoylquinic acid (21), pashaanolactone (26), 3,11-di-O-galloylbergenin (64), bergapten (66), kaempferol-3-O-rutinoside (70), quercetin-3-O-rutinoside ( 79), (+)-catechin-3-O-gallate (83), 2-O-caffeoylarbutin (86), leucocyanidin (124), methyl gallate (gallicin) (125), sitoinoside I ( 126), β-sitosterol-d-glucoside (127), avicularin (128), reynoutrin (129), procyanidin B1 (135), afzelin (140), and aloe-emodin (146).…”