Antimicrobial and Antioxidant Potentials of Endophytic Actinomycetes Isolated From Leaves of Asphodelus Tenuifolius (Cav.) (Marsa Matrouh, Egypt)

Fahmy, Dina M.; Sidkey, Nagwa M.; Elkawaga, Mai; Zaid, Doaa S

doi:10.21608/ejdr.2016.29639

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 (2021) endophytes act as a defense system for the host plants via releasing of wide range of bioactive metabolites such as alkaloids which act as inhibitors for insects and ants. It also reduces microbial infections and induces drought tolerance of host plant [10]. The herbs infected with endophytic fungi shows better resistance towards higher temperature.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Secondary Metabolites from Endophytic Aspergillus terreus AH1 Isolated from Ipomoea carnea Growing in Egypt

et al. 2021

Self Cite

View full text Add to dashboard Cite

Growing evidence indicates that the endophytic fungus Aspergillus is one of rich sources of natural products with a broad spectrum of biological activities. In our effort to isolate and to identify biologically active metabolites from naturally occurring sources, two endophytic fungi have been isolated from the tissues of Ipomoea carnea. Among the two isolates, one fungus displayed pronounced antimicrobial activity, against pathogenic microbes includes Gram+ve bacteria; Staphylococcus aureus and Bacillus subtilis, Gram-ve bacteria; Pseudomonas aeruginosa and Escherichia coli and Yeasts; Candida albicans with inhibition zone range from 16 to 19 mm. The most potent isolate has been identified genetically by sequencing of 18S rRNA gene as Aspergillus terreus AH1. Bioguided-fractionation and isolation of Aspergillus terreus AH1 extract led to identification of five compounds namely; (+)-asterrelenin ( 1), (±)-periplanamide B (2), butyrolactone I (3), pyranterrone D (4), and Arenarin A (5). The identified compounds showed a strong antibiofilm activity against human pathogenic bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Bacillus subtilis. Moreover, the compound ((±)-periplanamide B) has strong activity against some carcinoma cell lines such as HCT116, HePG 2 and MCF7

show abstract

Section: Introductionmentioning

confidence: 99%

Bioactive Secondary Metabolites from Endophytic Aspergillus terreus AH1 Isolated from Ipomoea carnea Growing in Egypt

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Free Radicals and Actinobacteria as a Misexplored Goldmine of Antioxidant Compounds

Oliveira

Gusmão

Silva

et al. 2021

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

Free radicals are highly reactive unstable molecules, which can be synthesized in different ways, considered harmful and threatening to humans; these chemical species have free traffi c throughout the human body, interacting with biological molecules and human body organ tissues. The interaction between free radicals and biological molecules is the main factor for disease development or pre-existing disease symptoms aggravation. Antioxidants are chemical compounds able to donate electric charge to stabilize molecules such as free radicals. Recent studies have proved the benefi ts of antioxidants intake in health improvement. In this way, the search for natural sources of antioxidants has become an ascending trend. In this fi eld, the microbial sources are considered poorly explored compared to the numerous amount of other compounds obtained from them, especially from Actinobacteria. The searched literature about Actinobacteria highlights an important capacity of producing natural antioxidants; however, there is a lack of in vivo studies of these isolated compounds. In this review, we gathered information that supports our point of view that Actinobacteria is a truly renewable and superfi cially explored source of natural antioxidants. Furthermore, our purpose is also to point this limitation and stimulate more researches in this area.

show abstract

Antimicrobial and Antioxidant Potentials of Endophytic Actinomycetes Isolated From Leaves of Asphodelus Tenuifolius (Cav.) (Marsa Matrouh, Egypt)

Cited by 2 publications

References 16 publications

Bioactive Secondary Metabolites from Endophytic Aspergillus terreus AH1 Isolated from Ipomoea carnea Growing in Egypt

Bioactive Secondary Metabolites from Endophytic Aspergillus terreus AH1 Isolated from Ipomoea carnea Growing in Egypt

Free Radicals and Actinobacteria as a Misexplored Goldmine of Antioxidant Compounds

Contact Info

Product

Resources

About