Antimicrobial and antioxidant properties of the flavonoid extract from Raphanus sativus L.

Ngoc, Pham Thi Kim; Nguyet, Nguyen Thi Minh; Đao, Đong Thi Anh

doi:10.1063/1.5000194

Cited by 5 publications

(2 citation statements)

References 4 publications

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“…In our study, all of the tested bacteria showed sensitivity to the R. sativus ethanolic extract with minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) ranging from 15 µg/mL to 500 µg/mL, tested by microdilution method (Table 1). Our results are better compared to previous results obtained by Ngoc et al (2017) indicating higher activity. They showed that MIC values for Salmonela typhi and Pseudomonas aeruginosa were 40 mg/mL, while for Bacillus cereus and Staphylococcus aureus were 20 mg/mL.…”

Section: Resultscontrasting

confidence: 77%

Sensitivity of Multiresistant Bacteria and Methicillin-Resistant Staphylococcus aureus to ethanolic root extract of Raphanus sativus

Stojković¹,

Smiljković²,

Nikolić³

et al. 2018

Lekovite sirovine

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Raphanus sativus L. (Brassicaceae) is an edible plant, whose root is consumed all over the world. The objective of this study was to test antibacterial potential of R. sativus ethanolic extract on 12 pathogenic bacteria including multiresistant bacterial strains and MRSA. All of the tested bacteria showed sensitivity to the antibacterial effect of R. sativus ethanolic extract with minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) in range of 15 µg/mL-500 µg/mL. It is interesting to note that Raphanus extract showed the highest activity against multiresistant strain of Pseudomonas aeruginosa with equal inhibitory and bactericidal concentrations of 15 µg/mL, while the most resistant strain to the effect of the extract was Proteus mirabilis (MIC and MBC of the extract were 300 µg/mL and 500 µg/mL, respectively). In disk diffusion assay, zones of inhibitions were measured ranging from 8 mm to 22 mm.

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Section: Resultscontrasting

confidence: 77%

Sensitivity of Multiresistant Bacteria and Methicillin-Resistant Staphylococcus aureus to ethanolic root extract of Raphanus sativus

Stojković¹,

Smiljković²,

Nikolić³

et al. 2018

Lekovite sirovine

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“…It showed 32.15%, 28.54%, 21.98%, and 20.86% of chelating activity, respectively. Te present study on leaves of R. sativus using ethanolic extract showed 4.76 ± 0.68% inhibition at 1 mg/mL of concentration [66].…”

Section: Discussionsupporting

confidence: 44%

Evaluation of Antioxidant and Anti-Inflammatory Activities, and Metabolite Profiling of Selected Medicinal Plants of Nepal

Shrivastava,

Keshari,

Neupane

et al. 2023

Journal of Tropical Medicine

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This study aimed to evaluate the antioxidant, antiarthritic, and anti-inflammatory properties of extracts from the leaves of twelve different medicinal plants in Nepal. We then evaluated the total phenolic, flavonoid, and tannin contents of the extract using in-vitro assays and characterized it using GC-MS analysis. Results revealed that most of the leaf extracts contained phenolic compounds, flavonoids, tannins, alkaloids, and saponins. Few plants also showed the presence of glycosides, phytate, and vitamin C. Among the studied plants, Neolamarckia cadamba exhibited the highest total phenolic and tannin contents, as 241.53 ± 0.20 µg of gallic acid equivalent/mg and 74.48 ± 1.081 µg of tannic acid equivalent/mg, respectively. Ipomoea batatas exhibited the highest total flavonoid content, as 53.051 ± 1.11 µg of quercetin equivalent/mg. Moreover, Raphanus sativus demonstrated significant ferrous ion chelating, 2,2-diphenyl-1-picrylhydrazyl, hydrogen peroxide scavenging, and total antioxidant activities with IC50 value of 4.76 ± 0.68 µg/mL, 5.84 ± 0.14 µg/mL, 6.89 ± 0.16 µg/mL, and 8.99 ± 0.20 µg/mL, respectively. Similarly, Colocasia esculenta and Cicer arietinum exhibited the highest hydroxyl radical and nitric oxide scavenging activities, measuring IC50 value of 7.22 ± 0.56 µg/mL and 9.06 ± 0.10 µg/mL, respectively. Among all the extracts, Amorphophallus paeoniifolius displayed significant human red blood cell (HRBC) membrane stabilization activity (IC50 = 6.22 ± 0.78 µg/mL). Furthermore, Raphanus sativus, Chenopodium album, Cicer arietinum, and Murraya koenigii exhibited the highest inhibitory activities against protein denaturation with bovine serum albumin, antiarthritic, lipoxygenase inhibitory, and proteinase inhibitory, measuring IC50 of 7.48 ± 0.48 µg/mL, 9.44 ± 1.62 µg/mL, 14.67 ± 1.94 µg/mL, and 28.57 ± 2.39 µg/mL, respectively. In conclusion, this study demonstrated the twelve leaf extracts’ significant antioxidant, antiarthritic, and anti-inflammatory activities.

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Flavonoids: isolation, characterization, and health benefits

Ekalu¹,

Habila

2020

Beni-Suef Univ J Basic Appl Sci

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Background The unique and vast pharmacological activities of flavonoids have made them of research interest. This led to the use of various techniques to isolate and characterize them, intending to determine their potential health benefits. Main text The medicinal values of plant-based flavonoids that this literature review tends to summarize the pharmacological activities of these secondary metabolites from 22 selected plant families. The pharmacological shreds of evidence reported in the literature have proven that flavonoids have shown anti-cancer, anti-microbial, anti-oxidant, anti-inflammatory, anti-fungal, anti-ulcer, and anti-edematogenic activities. Out of these, 30% showed to have anti-oxidant activity, key in protecting the body against free radicals. Besides, 18% of the references showed anti-microbial and anti-cancer activities. Further literature reports indicated that flavonoids from these families exhibited anti-inflammatory and anti-edematogenic (9%), anti-viral and anti-ulcer (5%), anti-fungal, anti-nociceptive, and anti-histamine (2%). Conclusion The pharmacological activities of flavonoids from the various sources reviewed in this study show that the secondary metabolites could provide a scaffold for the development of potent anti-cancer drugs in the future.

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Antimicrobial and antioxidant properties of the flavonoid extract from Raphanus sativus L.

Cited by 5 publications

References 4 publications

Sensitivity of Multiresistant Bacteria and Methicillin-Resistant Staphylococcus aureus to ethanolic root extract of Raphanus sativus

Sensitivity of Multiresistant Bacteria and Methicillin-Resistant Staphylococcus aureus to ethanolic root extract of Raphanus sativus

Evaluation of Antioxidant and Anti-Inflammatory Activities, and Metabolite Profiling of Selected Medicinal Plants of Nepal

Flavonoids: isolation, characterization, and health benefits

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