Antimicrobial and antiprotozoal activities of twenty-four Nigerian medicinal plant extracts

Ogbole, Omonike O.; Segun, Peter A.; Fasinu, Pius S.

doi:10.1016/j.sajb.2018.05.028

Cited by 37 publications

(21 citation statements)

References 43 publications

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“…In fact, 9 displayed SI value that is similar to that of vinblastine, indicating that it is only two to three times more cytotoxic to the cancer cells than the PNT2 cells. Recent studies have revealed the promising antibacterial, antifungal, antiprotozoal and antiviral activities of the extract of the leaves of M. barteri, and stated that at the tested doses, the extract could be considered relatively safe and non-toxic [40][41][42]. The antiproliferative activity of the DCM fraction of M. barteri reported herein and the abundance of cytotoxic compounds in this plant may provide evidence for its use in folklore medicine for the treatment of various cancers.…”

Section: Resultsmentioning

confidence: 60%

Bioassay-guided isolation and structure elucidation of cytotoxic stilbenes and flavonols from the leaves of Macaranga barteri

et al. 2019

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Section: Resultsmentioning

confidence: 60%

Bioassay-guided isolation and structure elucidation of cytotoxic stilbenes and flavonols from the leaves of Macaranga barteri

et al. 2019

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“…Arg. Agbaasa l 107230 0.01 Gonorrhoea, syphilis, skin infections, cancer and burns [ 37 ]. 16 Lamiaceae Hoslundia opposita Vahl Efirin-odan l 100866 10 Burns, skin infections, cough and malaria [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

In vitro antiviral activity of twenty-seven medicinal plant extracts from Southwest Nigeria against three serotypes of echoviruses

Ogbole

Akinleye

Segun

et al. 2018

Virol J

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BackgroundEchoviruses, a serotype of enteroviruses, infect millions of people globally and there is no specific drug treatment or vaccine available for its management. The screening of medicinal plants used locally for the treatment of infectious diseases, can provide a reliable option in the discovery of potent therapeutic compounds. This study was carried out to investigate the antiviral activities of 27 medicinal plant extracts, belonging to 26 different plant species, selected from Nigerian ethnobotany, against echovirus 7, 13 and 19 serotypes (E7, E13 and E19, respectively).MethodsThe plants were macerated in methanol and the cytotoxicities of the crude extracts were evaluated on the rhabdomyosarcoma cell line using the MTT assay. The antiviral activity of the plant extracts and fractions against echoviruses (E7, E13, and E19) was determined using the neutralisation assay, an assay that measures the inhibition of cytopathic effect on cell culture.ResultsThe crude extract of Macaranga barteri leaves had the highest cytotoxicity with CC50 value of 0.27 μg/mL. This was followed by Crinum jagus (9.88 μg/mL) and Terminalia ivorensis (12.14 μg/mL). The antiviral screening showed that ten out of the 27 crude plant extracts tested were active on E7 and E19, inhibiting the cytopathic effect of the virus in tissue culture. None of the extracts inhibited the cytopathic effect caused by E13 serotype. Amongst the active plant extracts, the methanol extract of M. barteri leaves had the highest antiviral activity on both E7 and E9 with IC50 values of 0.028 and 0.0017 ng/mL, respectively, followed by the Ageratum conyzoides extract (0.208 μg/mL, E7; 0.006 μg/mL, E19) and Mondia whitei extract (0.038 μg/mL, E7; 0.005 μg/mL, E19). Amongst the fractions of M. barteri, the DCM fraction was most the active and selective on E7 (IC50 = 0.0075 ng/mL; SI = 19,896.54) and E19 (IC50 = 0.0175 ng/mL; SI = 8581.24).ConclusionOur research has demonstrated that Macaranga barteri extracts has potent antiviral activity against echoviruses E7 and E19, and our findings suggest that this extract may have potential as a therapeutic agent in the treatment of enteroviral infections.

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“…The extract from solid-liquid extraction of NL root, using water as solvent, showed a high anti-parasitic potential. The aqueous extract also showed effectiveness against chloroquine resistance strains of plasmodium falciparum as well as exhibiting strong antibacterial property ( Ogbole et al., 2018 ). Owing to high consumption of N. latifolia root herb and commercialization prospect of the product in most of developing countries; it is necessary investigate phenolic solid-liquid extraction of NLR.…”

Section: Introductionmentioning

confidence: 99%

Black-box modelling, bi-objective optimization and ASPEN batch simulation of phenolic compound extraction from Nauclea latifolia root

Oke

Okolo

Adeyi

et al. 2021

Heliyon

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Nauclea latifolia root (NLR) extract is one of phytochemicals used to treat various ailments in most of developing countries. This investigation focuses on modelling, optimization and computer-aided simulation of phenolic solidliquid extraction from NLR. The extraction experiments were conducted at extraction temperature (ET: 33.79-76.21 C), process time (PT: 2.79-4.21 h) and solid-liquid ratio (SLC: 0.007929-0.018355 g/ml). Regression models (RM) were developed, using Response Surface Methodology (RSM) in Design Expert software, for predicting and optimizing total phenolic content (TPC) and total flavonoid content (TFC) and also compared with adaptive neuro-fuzzy inference system (ANFIS) modelling in Matlab environment. Aspen Batch Process Developer (ABPD) V10 was used to simulate phenolic extract production and perform material balance of the process. Both Coefficients of determination (R 2 ) of RSM (TFC: 0.9996, TPC: 0.9932) and ANFIS models (TFC: 0.99998, TPC: 0.9982) were compared and predicted satisfactorily. Optimization results show: ET (2.79 h), PT (38.8 C), SLC (0.0198 g/ml), TFC (25.92 25.92 μg RE/g) and TPC (8.47 mg GAE/g). The phenolic extraction base case simulation results gave batch throughput, annual throughput, number of batches per year 0.0089 g/batch, 0.139 g/year and 1019 batches, respectively. The ABPD predicted TPC and experimental TPC results were compared and gave mean relative deviation error of 3.75%. Thus, ABPD simulation model is reasonably reliable for the scale-up design engineering of the phenolic extract production from NLR.

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Antimicrobial and antiprotozoal activities of twenty-four Nigerian medicinal plant extracts

Cited by 37 publications

References 43 publications

Bioassay-guided isolation and structure elucidation of cytotoxic stilbenes and flavonols from the leaves of Macaranga barteri

Bioassay-guided isolation and structure elucidation of cytotoxic stilbenes and flavonols from the leaves of Macaranga barteri

In vitro antiviral activity of twenty-seven medicinal plant extracts from Southwest Nigeria against three serotypes of echoviruses

Black-box modelling, bi-objective optimization and ASPEN batch simulation of phenolic compound extraction from Nauclea latifolia root

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