Antimicrobial and Biofilm Inhibiting Diketopiperazines

Carvalho, Maira Peres de; Abraham, Wolf‐Rainer

doi:10.2174/092986712801323243

Cited by 144 publications

(103 citation statements)

References 127 publications

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“…Influence cell-cell signalling by modulating LuxR mediated quorum sensing system in bacteria [67,68] Pseudomonas chlororaphis (auerofaciens) strain…”

Section: Pseudomonas Aeruginosamentioning

confidence: 99%

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Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

et al. 2015

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Expression of certain bacterial genes only at a high bacterial cell density is termed as quorum-sensing (QS). Here bacteria use signaling molecules to communicate among themselves. QS mediated genes are generally involved in the expression of phenotypes such as bioluminescence, biofilm formation, competence, nodulation, and virulence. QS systems (QSS) vary from a single in Vibrio spp. to multiple in Pseudomonas and Sinorhizobium species. The complexity of QSS is further enhanced by the multiplicity of signals: (1) peptides, (2) acyl-homoserine lactones, (3) diketopiperazines. To counteract this pathogenic behaviour, a wide range of bioactive molecules acting as QS inhibitors (QSIs) have been elucidated. Unlike antibiotics, QSIs don't kill bacteria and act at much lower concentration than those of antibiotics. Bacterial ability to evolve resistance against multiple drugs has cautioned researchers to develop QSIs which may not generate undue pressure on bacteria to develop resistance against them. In this paper, we have discussed the implications of the diversity and multiplicity of QSS, in acting as an arsenal to withstand attack from QSIs and may use these as reservoirs to develop multi-QSI resistance.

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“…Influence cell-cell signalling by modulating LuxR mediated quorum sensing system in bacteria [67,68] Pseudomonas chlororaphis (auerofaciens) strain…”

Section: Pseudomonas Aeruginosamentioning

confidence: 99%

“…In P. aeruginosa, non-AHL signals such as diketopiperazines (DKPs): cyclo(DAla-L-Val) and cyclo(LPro-L-Tyr) were found to activate AHL biosensor ( Table 2) [67,68]. These signaling molecules were also found in Citrobacter freundii and Proteus mirabilis, whereas Enterobacter agglomerans was reported to possess only cyclo(DAla-L-Val).…”

Section: Pseudomonasmentioning

confidence: 99%

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

et al. 2015

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“…For example, indole is involved in the formation of biofilms by V. cholerae (Mueller et al 2009) and has significant activity against bacterial pathogens (Devi et al 2010). DKPs produced by many bacteria can work as signal molecules (Tommonaro et al 2012), inhibit the formation of biofilms (de Carvalho & Abraham 2012), the growth of bacteria ) and the settlement of larvae Qi, Xu, Gao et al 2009). Compounds which inhibit both microfouling and macrofouling should be investigated further as future potential AF agents.…”

Section: Looking Aheadmentioning

confidence: 99%

Mini-review: Inhibition of biofouling by marine microorganisms

2013

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Any natural or artificial substratum exposed to seawater is quickly fouled by marine microorganisms and later by macrofouling species. Microfouling organisms on the surface of a substratum form heterogenic biofilms, which are composed of multiple species of heterotrophic bacteria, cyanobacteria, diatoms, protozoa and fungi. Biofilms on artificial structures create serious problems for industries worldwide, with effects including an increase in drag force and metal corrosion as well as a reduction in heat transfer efficiency. Additionally, microorganisms produce chemical compounds that may induce or inhibit settlement and growth of other fouling organisms. Since the last review by the first author on inhibition of biofouling by marine microbes in 2006, significant progress has been made in the field. Several antimicrobial, antialgal and antilarval compounds have been isolated from heterotrophic marine bacteria, cyanobacteria and fungi. Some of these compounds have multiple bioactivities. Microorganisms are able to disrupt biofilms by inhibition of bacterial signalling and production of enzymes that degrade bacterial signals and polymers. Epibiotic microorganisms associated with marine algae and invertebrates have a high antifouling (AF) potential, which can be used to solve biofouling problems in industry. However, more information about the production of AF compounds by marine microorganisms in situ and their mechanisms of action needs to be obtained. This review focuses on the AF activity of marine heterotrophic bacteria, cyanobacteria and fungi and covers publications from 2006 up to the end of 2012.

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“…The bacterial capsular polysaccharide was found to inhibit many bacteria biofilm formation (Goncalves et al 2014), and a set of proteases immobilized on chitosan showed anti-biofilm activities on several pathogenic bacteria (Elchinger et al 2014). Diketopiperazines (DKPs), otherwise referred as cyclic dipeptides, have attracted the attention of microbial researchers for their biological activities including antibacterial (Prasad 1995;Qi et al 2009;De Carvalho and Abraham 2012;ElGendy and Rateb 2015), antifungal (Byun et al 2003), antifouling (Li et al 2006), antilarval (Qi et al 2009), and antitumor (Du et al 2010;Wang et al 2015) activities. DKPs have been isolated from various microorganisms, such as from fungi like Fusarium oxysporum (Trigos et al 1995), Porphyra yezoensis (Byun et al 2003), and Penicillium sp.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of biofilm in Bacillus amyloliquefaciens Q-426 by diketopiperazines

Wang

Yang

Fang

et al. 2016

World J Microbiol Biotechnol

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Biofilm formation can make significant effects on bacteria habits and biological functions. In this study, diketopiperazines (DKPs) produced by strain of Bacillus amyloliquefaciens Q-426 was found to inhibit biofilm formed in the gas-liquid interface. Four kinds of DKPs were extracted from B. amyloliquefaciens Q-426, and we found that 0.04 mg ml -1 DKPs could obviously inhibit the biofilm formation of the strain. DKPs produced by B. amyloliquefaciens Q-426 made a reduction on extracellular polymeric substance (EPS) components, polysaccharides, proteins, DNAs, etc. Real-time PCR was performed to determine that whether DKPs could make an obvious effect on the expression level for genes related to biofilm formation in the strain. The relative expression level of genes tasA, epsH, epsG and remB which related to proteins, extracellular matrix, and polysaccharides, were downregulated with 0.04 mg ml -1 DKPs, while the expression level of nuclease gene nuc was significantly upregulated. The quantitative results of the mRNA expression level for these genes concerted with the quantitative results on EPS levels. All of the experimental results ultimately indicated that DKPs could inhibit the biofilm formation of the strain B. amyloliquefaciens Q-426.

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Antimicrobial and Biofilm Inhibiting Diketopiperazines

Cited by 144 publications

References 127 publications

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

Mini-review: Inhibition of biofouling by marine microorganisms

Inhibition of biofilm in Bacillus amyloliquefaciens Q-426 by diketopiperazines

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