Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects

Mayr, Judith; Bachl, Jürgen; Schlossmann, Jens; Díaz, David Díaz

doi:10.3390/ijms18020303

Cited by 22 publications

(16 citation statements)

References 36 publications

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“…These salts were prepared by carrying out a chloride to iodide exchange of the initially used salts (see the supporting information for details). Very interestingly, this lead to a significant improvement in case of the A and B series (entries [17][18][19][20], which performed rather slow with chlorides only. On the other hand, those polymers that performed well for the chloride salts already (i.e.…”

Section: Resultsmentioning

confidence: 94%

“…To investigate the influence of the counter anion we next tested the corresponding iodide-based polymers (entries [17][18][19][20][21][22][23][24]. These salts were prepared by carrying out a chloride to iodide exchange of the initially used salts (see the supporting information for details).…”

Section: Resultsmentioning

confidence: 99%

“…ortho-, meta-, para-) in some of these polymers was found to play a key role on the hydrogelation [15], dye uptake [16] and antimicrobial properties [17]. In addition, our groups and others have shown that these versatile polymers can also serve as easily recoverable and reusable phase-transfer catalysts for a variety of different transformations [18][19][20].…”

Section: Introductionmentioning

confidence: 91%

“…MALDI-TOF measurements were collected with a Bruker Autoflex III Smartbeam spectrometer and on an Agilent atmospheric pressure photoionization (APPI) source on an Agilent 6520 quadrupole time-of-flight (QTOF) in the positive mode. The ionenes were synthesized as described recently [15,17]. The used epoxides were purchased from commercial suppliers and used without further purification.…”

Section: General Informationmentioning

confidence: 99%

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Cationic Polymers Bearing Quaternary Ammonium Groups-Catalyzed CO2 Fixation with Epoxides

et al. 2018

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A series of cationic polymers containing quaternary ammonium groups turned out to be powerful catalysts for the CO 2 -fixation of epoxides under an atmospheric pressure of CO 2 at elevated temperature. A variety of differently substituted aromatic and aliphatic epoxides were well tolerated and the polymeric catalysts could easily be recovered by a simple filtration and reused without any loss in catalytic activity.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: General Informationmentioning

confidence: 99%

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Cationic Polymers Bearing Quaternary Ammonium Groups-Catalyzed CO2 Fixation with Epoxides

et al. 2018

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“…This quaternized block had more rigid side chain than the PTTBM block used in the current study. Chain mobility is also an important factor for successful membrane disruption, as the cationic charge along flexible chain could better interact simultaneously with the bacterial membrane through multiple interactions …”

Section: Resultsmentioning

confidence: 99%

Contact Active Antimicrobial Coatings Prepared by Polymer Blending

Cuervo-Rodríguez

López-Fabal

Gómez-Garcés

et al. 2017

Macromolecular Bioscience

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Herein, contact active antimicrobial films are prepared by simply blending cationic amphiphilic block copolymers with commercial polystyrene (PS). The copolymers are prepared by combining atom transfer radical polymerization and "click chemistry." A variety of copolymers are synthesized, and composed of a PS segment and an antimicrobial block bearing flexible side chain with thiazole and triazole groups, 4-(1-(2-(4-methylthiazol-5-yl)ethyl)-1H-1,2,3-triazol-4-yl) butyl methacrylate (TTBM). The length of the TTBM block is varied as well as the alkylating agent. Different films are prepared from N,N-dimethylformamide solution, containing variable PS-b-PTTBM/PS ratio: from 0 to 100 wt%. Remarkably, the blend films, especially those with 30 and 50 wt% of copolymers, exhibit excellent antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi, even higher than films prepared exclusively from the cationic copolymers. Blends composed of 50 wt% of the copolymers present a more than 99.999% killing efficiency against the studied microorganisms. The better activity found in blends can be due to the higher roughness, which increases the surface area and consequently the contact with the microorganisms. These results demonstrate that the use of blends implies a reduction of the content of antimicrobial agent and also enhances the antimicrobial activity, providing new insights for the better designing of antimicrobial coatings.

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Antimicrobial, anti‐inflammatory, and antioxidant evaluations of ammonium and phosphonium salts based on poly(vinylbenzyl chloride‐co‐acrylonitrile)

Kenawy,

Azaam,

Kamoun

et al. 2024

J of Applied Polymer Sci

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Polymers with ammonium or phosphonium salts have been known to possess antimicrobial activity. Herein, synthesis of poly(vinylbenzyl chloride‐co‐acrylonitrile) (P(VBC‐co‐AN)) is reported via a free radical polymerization by employing AIBN as initiator. The copolymer was then quaternized using triethylamine, triphenylphosphine, and tributylphosphine. The triphenylphosphonium salt was selected for further modification, on which the polyacrylonitrile chains were reacted with two different amines: tris (2‐aminoethylamine) and diethylenetriamine. The copolymerization, quaternization, and amination reactions were confirmed by spectroscopic and morphologic analysis besides the thermal features. The water uptake of modified polymers was investigated, where tributylphosphonium salt (KH4) showed the highest water uptake capacity (41 g/g). The antimicrobial assay findings demonstrated that all the evaluated copolymers displayed a wide range of antimicrobial activity against different multidrug resistant human pathogens, for example polymer coded KH4 containing tributylphosphonium salt showed the highest growth inhibition rates against Staphylococcus aureus and Staphylococcus epidermidis populations, recorded 87% and 72%; respectively. The anti‐inflammatory activity revealed that all the quaternized copolymers have a protection effect of human erythrocyte membrane against lysis. Antioxidant results revealed that all quaternized copolymers displayed 1,1‐diphenyl‐2‐picryl hydrazyl scavenging activities. Among the studied copolymers, aminated copolymer coded (KH6) exhibited the highest scavenging activity, with IC50 ~ 120 μg/mL.

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Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects

Cited by 22 publications

References 36 publications

Cationic Polymers Bearing Quaternary Ammonium Groups-Catalyzed CO2 Fixation with Epoxides

Cationic Polymers Bearing Quaternary Ammonium Groups-Catalyzed CO2 Fixation with Epoxides

Contact Active Antimicrobial Coatings Prepared by Polymer Blending

Antimicrobial, anti‐inflammatory, and antioxidant evaluations of ammonium and phosphonium salts based on poly(vinylbenzyl chloride‐co‐acrylonitrile)

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