Antimicrobial and immunomodulating activities of hesperidin and ellagic acid against diarrheic Aeromonas hydrophila in a murine model

Abuelsaad, Abdelaziz S. A.; Mohamed, Imad; Allam, Gamal; Al-Solumani, Adnan A.

doi:10.1016/j.lfs.2013.09.019

Cited by 89 publications

(64 citation statements)

References 47 publications

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“…Eosinophils are considered to be important elements against helminth infection and immune response (BALIC et al, 2000;FINLAY et al, 2016). With respect to the phenolic compound, there is now emerging evidence that the plant metabolites exert immunomodulatory roleon systemic and intestinal compartments through selective actions on different components of the intracellular signalling cascades vital for cellular functions (ABUELSAAD et al, 2013).For example, a protective immunity against parasites was noted in animals treated with polyphenols. The therapeutic efficacy ofphenolics might be attributed to their stimulatory effects on the production of antibodies (OKAZAKI et al, 2010;Kaleemet al, 2014;KILANI-JAZIRI et al, 2016), leading to weight gains, FEC reduction and high IgA.…”

Section: Resultsmentioning

confidence: 99%

Anthelmintic activity of Cratyliamollis leaves against gastrointestinal nematodes in goats

Mendonça-Lima¹,

Santos

Santos³

et al. 2016

Rev. bras. saúde prod. anim.

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SUMMARY The present study assessed the in vivo anthelmintic activity of the C. mollis leaf decoction extract when administered orally to naturally infected goats with gastrointestinal nematodes. To this, animals were randomized into three groups:non-treated, control (treated with doramectin 1mL/50 kg b.w.) and C. mollis extract treated groups (2.5mg/kg b.w.). Blood and faecal samples were collected from each animal at day 0, and 30th day posttreatment to monitor immunological and parasitological parameters. A significant faecal egg reduction (61.1%) and an increase in IgA and eosinophils levels were observed in the C. mollis extract treated group, in comparison to the untreated and doramectin groups. Considering that gastrointestinal nematode infections in small ruminants are serious problems in the world, causing economic losses worldwide, associated to high anthelmintic cost, resistance to available anthelmintics and residue problems in meat and milk for human consumption, the plant extract use is an area of interest to search new anthelmintic agents. Thus, Cratyliamollis Mart. Ex Benth, an important medicinal plant from Brazilian Northeast semiarid region, is used to treat different types of diseases, and as forage supplementation. Therefore, the data indicated the potential anthelmintic activity of C. mollis extract; further research is thereby warranted to assess its value for therapeutic purposes.

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Section: Resultsmentioning

confidence: 99%

Anthelmintic activity of Cratyliamollis leaves against gastrointestinal nematodes in goats

Mendonça-Lima¹,

Santos

Santos³

et al. 2016

Rev. bras. saúde prod. anim.

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“…Supporting these findings, improvement in the immune status and lower mortality was reported after inclusion of Ginkgo biloba extract and Camelia sinensis in broilers. The elevation serum immnonoglobulin level indicating the natural antibodies impact which might be attributable to enlargement of the splenic lymphocite due to the probiotic effect and combination of polyphenolic compounds (derived from Punica granatum, Ginkgo biloba and Citrus junos) [47]. Supplementation of probiotics elevate the capability of the splenic lymphocytes to the proliferation in tesponse to the B-cell and T-cell mitogenic stimulation [48,49].…”

Section: Discussionmentioning

confidence: 99%

“…Dietary inclusion of 10% fermented Gingkgo biloba reported to be beneficial to improve immune function in the case of weaned piglets [50], which in turn supports the results of our study regarding higher serum immunoglobulin levels in the case of FGLP supplementation of broilers. The presence of flavonoids (dominance of hesperidin) and vitamin C (L-ascorbic acid) in case of Citrus junos and fermentation with probiotics ascribed to be the reason of improvement in the humoral immunity of birds [47,51].…”

Section: Discussionmentioning

confidence: 99%

Performance, Immunity, Meat Composition and Fatty Acid Pattern in Broilers after Dietary Supplementation of Fermented Ginkgo biloba and Citrus junos

Kim¹,

Abm²,

Islam³

et al. 2017

J Nutr Food Sci

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Dietary Fermented Ginkgo biloba (FGLP) and Citrus junos Probiotics (FCJP) was evaluated on growth performance, immunity, cecal microbiology, meat composition and fatty acid profile in broilers. A total of 150 one day old Ross 308 broilers were randomly allocated to the 5 treatments (5 replicated pen of 6 birds/pen): 1) Control (corn-soybean meal based basal diet), 2) FGLP1: Corn-soybean meal based basal diet+5% FGLP, 3) FGLP2: Cornsoybean meal based basal diet+10% FGLP, 4) FCJP1: Corn-soybean meal based basal diet+5% FCJP, and 5) FCJP2: Corn-soybean meal based basal diet+10% FCJP. A significant increase in weight gain during starter (0-21 days), finisher (22-35 days) and overall period (0-35 days) was exhibited in FGLP2 supplemented group compared to control and other treatment groups (P<0.05); where better feed conversion efficiency was found after FCJP2 supplementation during finisher and overall period compared to control and other treatment groups (P<0.05). Serum IgG was elevated in FGLP and FCJP supplemented group relative to control birds (P<0.05). Meat composition data elucidated that, thigh meat crude protein and crude fat content was increased in FCJP1 supplemented group compared to control (P<0.05). There was found no significant differences in meat cholesterol content between control and treatment groups (P>0.05); however, among meat fatty acids, sum of SFA in thigh meat was diminished in FGLP group and sum of MUFA in breast meat was diminuted in FGLP and FCJP group compared to control (P<0.05). Sum of n-3 PUFA of breast and thigh meat was elevated after supplementation of FGLP and FCJP compared to control (P<0.05). To sum up, dietary FGLP and FCJP supplementation significantly improved performance and immunity, decreased SFA and elevated n-3 PUFA of broiler meat. Therefore, FGLP and FCJP probiotics could be supplemented as functional feed additives in broilers diet.

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“…It plays an important role in prevention of many diseases due to its anti-oxidant, anti-inflammatory, anticarcinogenic, anti-ulcer activities [17,18] , in addition to its antimelanogenic and neuroprotective effects [19,20] . Moreover, it has anti-microbial, anti-allergic, immunomodulatory, hepatoprotective, and nephroprotective effects [21][22][23] . The ameliorative role of hesperidin against tissue toxicities induced by various chemotherapeutic agents as doxorubicin, methotrexate, and cisplatin has been reported [24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

The Potential Protective Role of Hesperidin Against Capecitabine-Induced Corneal Toxicity in Adult Male Albino Rat. Light and Electron Microscopic Study

Elwan

Kassab

2017

Egyptian Journal of Histology

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Background: Capecitabine is a chemotherapeutic agent widely used for the treatment of malignancies. Ocular disorders have been reported with capecitabine therapy. Hesperidin is a naturally occurring compound derived mainly from citrus fruits and has a wide range of pharmacological activities and a proposed role in combating many ocular diseases. Aim: To evaluate the potential protective role of hesperidin against the corneal toxicity caused by capecitabine in adult male albino rats. Material and Methods: Thirty-six adult male albino rats were divided into four equal groups; control group, hesperidintreated group (50 mg/kg), capecitabine-treated group (40 mg/kg), and combination-treated "capecitabine and hesperidintreated" group. Animals were orally administered once daily for one month. Specimens from the cornea were processed for light and electron microscopy. Immunohistochemical study was performed using antibodies against p53. Results: Specimens from capecitabine-treated animals showed significant decrease of epithelial thickness. The corneal epithelial cells showed nuclear alteration and vacuolated cytoplasm. The stromal collagen fibers were irregularlyarranged and widely separated with neovascularization and mononuclear cellular infiltration. Ultrastructurally, focal widening of the intercellular spaces, partial loss of desmosomal junctions and swollen mitochondria were observed. The immunohistochemical study showed a significant increase in p53 immunoreaction. In contrast, minimal changes were observed in rats treated concomitantly with both capecitabine and hesperidin, with a non significant increase in the immunoreactions. Conclusion: Capecitabine induced structural changes in cornea of adult albino rat that could be ameliorated by concomitant treatment with hesperidin.

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Antimicrobial and immunomodulating activities of hesperidin and ellagic acid against diarrheic Aeromonas hydrophila in a murine model

Cited by 89 publications

References 47 publications

Anthelmintic activity of Cratyliamollis leaves against gastrointestinal nematodes in goats

Anthelmintic activity of Cratyliamollis leaves against gastrointestinal nematodes in goats

Performance, Immunity, Meat Composition and Fatty Acid Pattern in Broilers after Dietary Supplementation of Fermented Ginkgo biloba and Citrus junos

The Potential Protective Role of Hesperidin Against Capecitabine-Induced Corneal Toxicity in Adult Male Albino Rat. Light and Electron Microscopic Study

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