Antimicrobial and P450 Inhibitory Properties of Common Functional Foods

Abstract

-PURPOSE: To study the effect of functional foods on human cytochrome P450 (CYP) and the gut bacterial microflora that may potentially affect drug metabolism and ultimately affect human health and wellness. METHODS: This study examined a variety of food plants from the Apiaceae, Fabaceae, and Lamiaceae families for their inhibitory potential on cytochrome 2D6-, 3A4-, 3A5-, and 3A7-mediated metabolism. The antimicrobial effects of these samples were also investigated with 7 selected bacterial surrogate species to determine potential effects on the gut microflora. RESULTS: The highest CYP inhibitory activities, based upon visual examination, were observed from extracts of celery seed, cumin, fennel seed, basil, oregano, and rosemary belonging to the Apiaceae and Lamiaceae families, respectively. Likewise, the strongest antimicrobial activities were also observed in the Apiaceae and Lamiaceae. No significant antimicrobial and CYP inhibition was observed in the Fabaceae extracts. CONCLUSION: Results demonstrated the possible risk of food-drug interactions from spice and herb plants may affect drug disposition and safety.

Antibacterial and Antifungal Activities of Spices

“…coli , respectively. Nguyen et al [123] evaluated the antimicrobial activities of methanol and ethanol extracts of eight spices against B . subtilis , E. faecalis , L .…”

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

“…Besides, it is inhibitory of dipeptidyl peptidase IV in the diabetes management (Bower et al 2014) and its nephropathy and neuropathy complications (Martynyuk et al 2014;Ramachandran et al 2014 (Rašković et al 2014;da Silva Bomfim et al 2015). It is consumed as a functional food with antimicrobial capacity (Nguyen et al 2014) and a phytomedicine for skin wound healing (Pazyar et al 2014). It had inhibition of formalin-induced pain and inflammation in mice (Emami et al 2013) and H 2 O 2 induced oxidative DNA damage in human lymphocytes (Razavi-Azarkhiavi et al 2014).…”

Bioactive properties: enhancement of hepatoprotective, antioxidant and DNA damage protective effects of golden grey mullet protein hydrolysates against paracetamol toxicity

“…9 The past decade has also witnessed intense interest in functional foods or dietary photochemical which can inuence the pharmacological activity of drugs and their toxicities by modifying metabolism system, including drug-metabolizing enzymes and transporters. 10 In the pharmaceutical industry, liver, a vital organ in the body responsible for metabolizing and detoxication of substances, 11 is one of the routinely assessed organs during preclinical safety evaluations. Indeed several biological compounds with antioxidant properties proved effective in protecting the liver against deleterious effects of paracetamol overdose.…”