Antimicrobial and pharmaceutical properties of <i>Khaya senegalensis</i> seed oil

Anti-Dermatophytic Potential of Formulated Extract of Cola nitida (Vent.) Schott& Endl. (Stem Bark)

“…Extract was formulated into cream [14] and consists of extract (32 g), emulsifying wax (4.0), oleic acid (2.0), Tri-ethanolamine (2.0), Glycerol (1.0) and water. Briefly the emulsifying wax in a flask was dissolved by placing the flask in temperature-regulated water bath.…”

An aqueous extract of Khaya senegalensis (Desv.) A. Juss. (Meliaceae) prevents seizures and reduces anxiety in kainate-treated rats: modulation of GABA neurotransmission, oxidative stress, and neuronal loss in the hippocampus

“…Assuming that the reduction of ROS and free radicals are indicators of the presence of bioactive molecules with antioxidant activities ( Allah et al., 2018 ; Moto et al., 2018 ), the presence of secondary metabolites (flavonoids and polyphenols) with antioxidant potential might explain these properties of the extract ( Marius et al., 2016 ; Allah et al., 2018 ). Indeed, the qualitative and quantitative phytochemical analysis of the extract revealed the presence of tannins, coumarins, phenols, triterpenes, and flavonoids, all of which are known to possess antioxidant potential ( Audu-Peter et al., 2006 ; Kolawole et al., 2013 ; Atawodi et al., 2014 ; Marius et al., 2016 ). Due to the documented preventive effect of antioxidants against neuronal alterations or loss, these findings also highlight the neuroprotective effect of the extract ( Frantseva et al., 2000 ; Gupta et al., 2003 ).…”

“…(Meliaceae) ( http://www.worldfloraonline.org ) roots are used in traditional medicine to treat skin problems, jaundice, edema, neurological disorders, headaches, schizophrenia, epilepsy, and mental disorders ( Maiga et al., 2005 ; Atawodi et al., 2014 ; Taiwe and Kuete, 2014 ). In Nigeria and West Africa, the stem bark and roots extracts are used to treat jaundice, syphilis, malaria, leprosy, dermatosis, epilepsy, and hookworm infections, while seeds and leaves are used to treat fever, headaches, mental illness ( Audu-Peter et al., 2006 ; Sule et al., 2008 ; Taiwe and Kuete, 2014 ; Kinda et al., 2017 ). Pharmacological studies on the stem bark and roots of K. senegalensis have revealed anti-inflammatory ( Thioune et al., 2000 ; Zhou et al., 2018 ), antioxidant, antibacterial, anthelmintic, anticancer, and immune-enhancing properties ( Olayinka et al., 1992 ; Thioune et al., 2000 ; Audu-Peter et al., 2006 ; Kolawole et al., 2013 ; Atawodi et al., 2014 ).…”

“…In Nigeria and West Africa, the stem bark and roots extracts are used to treat jaundice, syphilis, malaria, leprosy, dermatosis, epilepsy, and hookworm infections, while seeds and leaves are used to treat fever, headaches, mental illness ( Audu-Peter et al., 2006 ; Sule et al., 2008 ; Taiwe and Kuete, 2014 ; Kinda et al., 2017 ). Pharmacological studies on the stem bark and roots of K. senegalensis have revealed anti-inflammatory ( Thioune et al., 2000 ; Zhou et al., 2018 ), antioxidant, antibacterial, anthelmintic, anticancer, and immune-enhancing properties ( Olayinka et al., 1992 ; Thioune et al., 2000 ; Audu-Peter et al., 2006 ; Kolawole et al., 2013 ; Atawodi et al., 2014 ). Furthermore, neuropharmacological studies of the aqueous extract of stem bark showed antiepileptic and sedative effects on seizures in mice ( Ngo Bum et al., 2011 ).…”