Antimicrobial and physicochemical characterization of 2,3-dialdehyde cellulose-based wound dressings systems

Mayer, Sophie; Tallawi, Marwa; Luca, Ilenia De; Calarco, Anna; Reinhardt, Nikita; Gray, L. Avila; Drechsler, Klaus; Moeini, Arash; Germann, Natalie

doi:10.1016/j.carbpol.2021.118506

Cited by 24 publications

(9 citation statements)

References 80 publications

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“…The antimicrobial efficacy of QUE-loaded membranes was assessed by monitoring the inhibition of Pseudomonas aeruginosa PAO1 and the growth rate of Streptococcus mutans (S. mutans) , as previously described with some modifications [ 27 ]. Briefly, an electrospun membrane of similar dimensions was sterilized by UV radiation for 15 min at each side, placed in a 12-well plate, covered with 500 μL of liquid broth supplemented with 20% sucrose and inoculated with a bacterial suspension containing a microbial concentration of approximately 1 × 10 7 CFU/mL.…”

Section: Methodsmentioning

confidence: 99%

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Cristo¹,

Valentino²,

Luca³

et al. 2022

Molecules

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The management of periodontitis remains a vital clinical challenge due to the interplay between the microorganisms of the dental biofilm and the host inflammatory response leading to a degenerative process in the surrounding tissues. Quercetin (QUE), a natural flavonol found in many foods, including apples, onions and tea, has exhibited prolonged and strong antibiofilm and anti-inflammatory effects both in vitro and in vivo. However, its clinical application is limited by its poor stability and water solubility, as well as its low bioavailability. Thus, in the present study, electrospun polylactic acid (PLA) nanofibers loaded with different amounts (5–10% w/w) of QUE were produced to rapidly respond to the acidic microenvironment typical of periodontal pockets during periodontal disease. This strategy demonstrated that PLA-QUE membranes can act as a drug reservoir releasing high QUE concentrations in the presence of oral bacterial infection (pH < 5.5), and thus limiting Pseudomonas aeruginosa PAO1 and Streptococcus mutans biofilm maturation. In addition, released QUE exerts antioxidant and anti-inflammatory effects on P. gingivalis Lipopolysaccharide (LPS)-stimulated human gingival fibroblast (HGFs). The reported results confirmed that PLA-QUE membranes could inhibit subgingival biofilm maturation while reducing interleukin release, thereby limiting host inflammatory response. Overall, this study provided an effective pH-sensitive drug delivery system as a promising strategy for treating periodontitis.

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Section: Methodsmentioning

confidence: 99%

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Cristo¹,

Valentino²,

Luca³

et al. 2022

Molecules

Self Cite

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“…), malnutrition, and poor wound care are the main factors leading to chronic wounds that put a physical, psychological, social, and financial burden on patients [ 2 , 9 , 10 ]. Wound infections caused by bacteria (mainly Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , Bacteroides fragilis ) are one of the most predominant reasons for the prolongation of wound healing (in the inflammatory stage) [ 1 , 11 , 12 , 13 ]. These bacteria form colonies at the wound site and may overcome the patient’s immunity, resulting in tissue damage and life-threatening consequences [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous kinds of dressing materials have been in human use since ancient times, with the primary aim being to cover the wound to provide protection against the environment and prevent bleeding and further injury [ 5 , 12 , 16 ]. Wound dressing in current practice can be broadly classified into dry/traditional (cotton, gauze, bandage) and moist/modern (films, foams, hydrogels, sponges, hydro actives, hydrofibers) dressings [ 8 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Wound dressing in current practice can be broadly classified into dry/traditional (cotton, gauze, bandage) and moist/modern (films, foams, hydrogels, sponges, hydro actives, hydrofibers) dressings [ 8 , 17 ]. Dry dressings are still in clinical practice despite possessing the main limitations of wound dehydration and risk of infection [ 12 , 18 , 19 ]. Conversely, modern dressings augment wound healing by preventing dehydration and facilitating cell proliferation [ 12 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dry dressings are still in clinical practice despite possessing the main limitations of wound dehydration and risk of infection [ 12 , 18 , 19 ]. Conversely, modern dressings augment wound healing by preventing dehydration and facilitating cell proliferation [ 12 , 17 ]. Additionally, antimicrobial agents can be incorporated into the polymeric dressings for delivery into the wound bed to prevent wound infections [ 8 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Development and Characterization of Gentamicin-Loaded Arabinoxylan-Sodium Alginate Films as Antibacterial Wound Dressing

Alzarea

Alruwaili

Ahmad

et al. 2022

IJMS

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Biopolymer-based antibacterial films are attractive materials for wound dressing application because they possess chemical, mechanical, exudate absorption, drug delivery, antibacterial, and biocompatible properties required to support wound healing. Herein, we fabricated and characterized films composed of arabinoxylan (AX) and sodium alginate (SA) loaded with gentamicin sulfate (GS) for application as a wound dressing. The FTIR, XRD, and thermal analyses show that AX, SA, and GS interacted through hydrogen bonding and were thermally stable. The AXSA film displays desirable wound dressing characteristics: transparency, uniform thickness, smooth surface morphology, tensile strength similar to human skin, mild water/exudate uptake capacity, water transmission rate suitable for wound dressing, and excellent cytocompatibility. In Franz diffusion release studies, >80% GS was released from AXSA films in two phases in 24 h following the Fickian diffusion mechanism. In disk diffusion assay, the AXSA films demonstrated excellent antibacterial effect against E.coli, S. aureus, and P. aeruginosa. Overall, the findings suggest that GS-loaded AXSA films hold potential for further development as antibacterial wound dressing material.

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Dialdehyde cellulose as a niche material for versatile applications: an overview

Dalei

Das

Pradhan³

2022

Cellulose

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Antimicrobial and physicochemical characterization of 2,3-dialdehyde cellulose-based wound dressings systems

Cited by 24 publications

References 80 publications

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Development and Characterization of Gentamicin-Loaded Arabinoxylan-Sodium Alginate Films as Antibacterial Wound Dressing

Dialdehyde cellulose as a niche material for versatile applications: an overview

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