Antimicrobial and SOD activities of novel transition metal complexes of pyridine-2,6-dicarboxylic acid containing 4-picoline as auxiliary ligand

Siddiqi, Zafar A.; Khalid, Mohd; Kumar, Sushil; Shahid, M.; Noor, Shabana

doi:10.1016/j.ejmech.2009.10.005

Cited by 132 publications

(65 citation statements)

References 29 publications

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“…Spores of various Bacillus species contain high levels (25% of spore core dry weight) of pyridine-2,6-dicarboxylic acid (dipicolinic acid [DPA]) 1) DPA is a multi-functional compound, and its derivatives are expected to use as antimicrobial activity reagents, 2) antioxidants, 3) biodegradable chelating reagents, 4) hair growth-promoting reagents, 5) and components of sustainable bio-based polymers. 6) Despite the unique features of DPA, there are few reports of DPA production by fermentation.…”

mentioning

confidence: 99%

Increased dipicolinic acid production with an enhanced spoVF operon in Bacillus subtilis and medium optimization

Takahashi

Sumitomo

Hagihara

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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Dipicolinic acid (DPA) is a multi-functional agent for cosmetics, antimicrobial products, detergents, and functional polymers. The aim of this study was to design a new method for producing DPA from renewable material. The Bacillus subtilis spoVF operon encodes enzymes for DPA synthase and the part of lysine biosynthetic pathway. However, DPA is only synthesized in the sporulation phase, so the productivity of DPA is low level. Here, we report that DPA synthase was expressed in vegetative cells, and DPA was produced in the culture medium by replacement of the spoVFA promoter with other highly expressed promoter in B. subtilis vegetative cells, such as spoVG promoter. DPA levels were increased in the culture medium of genetically modified strains. DPA productivity was significantly improved up to 29.14 g/L in 72 h culture by improving the medium composition using a two-step optimization technique with the Taguchi methodology.

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confidence: 99%

Increased dipicolinic acid production with an enhanced spoVF operon in Bacillus subtilis and medium optimization

Takahashi

Sumitomo

Hagihara

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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“…Several transition metal mixed-ligand complexes with flexible geometric transformations around the metal centers, especially Mn, Cu, or Zn, can act as SOD enzymes even though their structures are totally unrelated to the native enzyme. 5 The calculated SC 50 value for the native SOD enzyme was much lower than those for the molecules studied, but the activities of the ligands and complexes were comparable to the results of previously studied molecules in the literature, such as Co and Zn complexes of the 2, 6-di((phenazonyl-4-imino) methyl)-4-methylphenol ligands. 43 The molecules investigated in the present study may be used as the SOD enzyme mimic.…”

Section: 41mentioning

confidence: 55%

“…4 Therefore, complexes synthesized from the same ligands with different metal ions have different biological properties. 5 In the present study the drug efficiencies of the transition metal complexes of two different oxime ligands were evaluated as a result of their interactions with DNA. Oximes are widely identified ligands and the potential applications of their metal complexes are of great interest to scientists.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands

Ayvaz¹,

Turan²,

Dural³

et al. 2017

Turk J Chem

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Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) transition metal complexes of 2-hydroxy-5-[(E)-(4-phenyl) diazenyl]benzaldehyde oxime and 2-hydroxy-5-[(E)-(4-nitrophenyl) diazenyl] benzaldehyde oxime ligands were synthesized and characterized through NMR, IR, ESI mass, and UV analysis. DNA binding abilities of the complexes were revealed using a UV-Vis spectrophotometer with the absorption titration and competitive binding techniques. Hydrolytic and oxidative DNA cleavage activities under different conditions were also proved. Topoisomerase I inhibition efficiencies and in vitro free radical scavenging activities of all complexes were examined. Finally, the selective cytotoxic potentials of all complexes were evaluated in human colon cancer, normal colon, and fibroblast cell lines using the water-soluble tetrazolium salt (WST-1) assay. The complexes had the ability to intercalate into stacked base pairs of DNA and topoisomerase I activity was reasonably inhibited in their presence in 0.4 mM concentrations. The abilities for scavenging of DPPH and hydroxyl radicals were found to be higher than those of known standard antioxidants (ascorbic acid, butylated hydroxyanisole, and mannitol). The results obtained from the cytotoxicity experiments are especially promising for further research, which must be carried out for the evaluation of the studied complexes as anticancer drugs.

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“…The therapeutic potential of metal complexes depends on the ligand as well as nature of metal ions [18]. Some literature revealed that different ligands and different complexes synthesized from same ligands with different metal ions possess different biological properties [17,[19][20][21]. Upon testing metal complexes as antioxidants the test results show that they could effectively facilitate the scavenging of excess ROS.…”

Section: Characterization Of the Cr(iii)-complexesmentioning

confidence: 98%

“…The presence of metal ions in the complexes accelerates the activity and efficacy of organic therapeutic agents [17]. The therapeutic potential of metal complexes depends on the ligand as well as nature of metal ions [18].…”

Section: Characterization Of the Cr(iii)-complexesmentioning

confidence: 99%

Synthesis, Characterization and Antioxidant Activity of Potassium Cis-Diaqua-Bis (Oxalato) Chromate (Iii) With Levodopa and Carbidopa

Rout

Pattanaik

Chandra

et al. 2018

Int J Pharm Pharm Sci

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Objective: These studies focus on the interaction between two clinically active antiparkinsonian drugs L-dopa (L) and carbidopa (C) with the cis-[Cr(C2O4)2(H2O)2] - Methods:The resulting synthesized complexes were characterized by UV-VIS and FTIR spectroscopy. Evaluation of antioxidant activities of this cis-[Cr(C and evaluation of the synthesized product from a coordination chemistry aspect with respect to the possibility of its antioxidant activity and its therapeutic application in the treatment of Parkinson disease. Results:The results of spectral analysis of the synthesized products indicate that complexes have a Cr(III) ion coordinated via the carboxylic and amino group. In the reduction of radical DPPH -carbidopa(MC) and standard butylated hydroxytoluene (BHT) were carried out by using 1,1-diphenyl-1-picrylhydrazyl free radical (DPPH), 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cations and hydrogen peroxide method.· and the formation of radical monocation ABTS ·+ the ability to scavenge radical was measured in these experiments by the discoloration of the solution. However, in hydrogen peroxide method, the increased in absorbance showing its scavenging potential. The scavenging capacity of the test compounds and standard on the DPPH, ABTS ·+ , H2O2 decreased in the order BHT>ML>MC>C>L which were 98.4, 96.4, 86.4, 68.3, 49.7% for DPPH, BHT>ML>L>MC>C which were 99.3, 96.9, 96.3,66.6, 53.4% for ABTS ·+ , BHT>ML>MC>L>C which were 68.8%, 52.4%, 49.6%, 43.1% and 37.7% for H2O2 Conclusion:The experimental findings showed that cis-[Cr(C at the concentration of 50 µg/ml, respectively.

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Antimicrobial and SOD activities of novel transition metal complexes of pyridine-2,6-dicarboxylic acid containing 4-picoline as auxiliary ligand

Cited by 132 publications

References 29 publications

Increased dipicolinic acid production with an enhanced spoVF operon in Bacillus subtilis and medium optimization

Increased dipicolinic acid production with an enhanced spoVF operon in Bacillus subtilis and medium optimization

Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands

Synthesis, Characterization and Antioxidant Activity of Potassium Cis-Diaqua-Bis (Oxalato) Chromate (Iii) With Levodopa and Carbidopa

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